Human TRAIL R2/TNFRSF10B Antibody | R&D Systems AF631 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human TRAIL R2/TNFRSF10B Antibody

catalog :

AF631

quantity :

100 ug (also 25 ug)

price :

459 USD

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunocytochemistry, neutralization, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section

more info or order :

R&D Systems product webpage

citations: 9

Reference
Yerbes R, Mora Molina R, Fern xe1 ndez Farr xe1 n F, Hiraldo L, L xf3 pez Rivas A, Palacios C. Limiting glutamine utilization activates a GCN2/TRAIL-R2/Caspase-8 apoptotic pathway in glutamine-addicted tumor cells. Cell Death Dis. 2022;13:906 pubmed publisher
Mora Molina R, St xf6 hr D, Rehm M, L xf3 pez Rivas A. cFLIP downregulation is an early event required for endoplasmic reticulum stress-induced apoptosis in tumor cells. Cell Death Dis. 2022;13:111 pubmed publisher
Jeong D, Kim H, Kim H, Kang M, Jung H, Oh Y, et al. Soluble Fas ligand drives autoantibody-induced arthritis by binding to DR5/TRAIL-R2. elife. 2021;10: pubmed publisher
Kopczynski M, Statkiewicz M, Cybulska M, Kuklinska U, Unrug Bielawska K, Sandowska Markiewicz Z, et al. Cytotoxic Efficacy and Resistance Mechanism of a TRAIL and VEGFA-Peptide Fusion Protein in Colorectal Cancer Models. Int J Mol Sci. 2021;22: pubmed publisher
An Y, Jeon J, Sun L, Derakhshan A, Chen J, Carlson S, et al. Death agonist antibody against TRAILR2/DR5/TNFRSF10B enhances birinapant anti-tumor activity in HPV-positive head and neck squamous cell carcinomas. Sci Rep. 2021;11:6392 pubmed publisher
Park S, Han H, Ahn S, Ryu C, Jeun S. Combination treatment with VPA and MSCs‑TRAIL could increase anti‑tumor effects against intracranial glioma. Oncol Rep. 2021;45:869-878 pubmed publisher
Shlyakhtina Y, Pavet V, Gronemeyer H. Dual role of DR5 in death and survival signaling leads to TRAIL resistance in cancer cells. Cell Death Dis. 2017;8:e3025 pubmed publisher
Liapis V, Zysk A, DeNichilo M, Zinonos I, Hay S, Panagopoulos V, et al. Anticancer efficacy of the hypoxia-activated prodrug evofosfamide is enhanced in combination with proapoptotic receptor agonists against osteosarcoma. Cancer Med. 2017;6:2164-2176 pubmed publisher
Ricci Vitiani L, Pedini F, Mollinari C, Condorelli G, Bonci D, Bez A, et al. Absence of caspase 8 and high expression of PED protect primitive neural cells from cell death. J Exp Med. 2004;200:1257-66 pubmed

product information

master code :

AF631

SKU :

AF631

product name :

Human TRAIL R2/TNFRSF10B Antibody

unit size :

100 ug (also 25 ug)

description :

The Human TRAIL R2/TNFRSF10B Antibody from R&D Systems is a goat polyclonal antibody to TRAILR2/TNFRSF10B. This antibody reacts with human. The Human TRAIL R2/TNFRSF10B Antibody has been validated for the following applications: Flow Cytometry,Immunoprecipitation,Western Blot,Neutralization,Functional Assay,Immunohistochemistry-Paraffin,Immunocytochemistry,Agonist Activity.

target :

TRAIL R2/TNFRSF10B

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Polyclonal

concentration :

LYOPH

conjugate :

Unconjugated

host :

Goat

immunogen :

Mouse myeloma cell line NS0-derived recombinant human TRAIL R2/TNFRSF10B, Ala54-Glu182, Accession # Q6FH58

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Human

specificity :

Detects human TRAIL R2/TNFRSF10B in direct ELISAs and Western blots.

gene symbol :

TNFRSF10B

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

top caption :

Detection of Human TRAIL R2/TNFRSF10B antibody by Western Blot.

accessionNumbers :

Q6FH58

applications :

Flow Cytometry,Immunoprecipitation,Western Blot,Neutralization,Functional Assay,Immunohistochemistry-Paraffin,Immunocytochemistry,Agonist Activity

USD :

459 USD

alt names :

CD262, CD262 antigen, death domain containing receptor for TRAIL/Apo-2L, Death receptor 5, DR5, DR5TRICK2B, Fas-like protein, KILLER/DR5, KILLERapoptosis inducing protein TRICK2A/2B, TNF-related apoptosis-inducing ligand receptor 2, TNFRSF10B, TRAIL receptor 2, TRAILR2, TRAIL-R2apoptosis inducing receptor TRAIL-R2, TRAILR2cytotoxic TRAIL receptor-2, TRICK2, TRICK2A, TRICKB, tumor necrosis factor receptor superfamily member 10B, tumor necrosis factor receptor superfamily, member 10b, tumor necrosis factor receptor-like protein ZTNFR9, ZTNFR9

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage