Human/Mouse PRDM16/MEL1 Antibody | R&D Systems AF6295 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human/Mouse PRDM16/MEL1 Antibody

catalog :

AF6295

quantity :

100 ug (also 25 ug)

price :

489 USD

clonality :

polyclonal

host :

domestic sheep

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunoprecipitation, chromatin immunoprecipitation, immunohistochemistry - frozen section

more info or order :

R&D Systems product webpage

citations: 16

Reference
He H, Bell S, Davis A, Zhao S, Sridharan A, Na C, et al. PRDM3/16 regulate chromatin accessibility required for NKX2-1 mediated alveolar epithelial differentiation and function. Nat Commun. 2024;15:8112 pubmed publisher
Suresh V, Bhattacharya B, Tshuva R, Danan Gotthold M, Olender T, Bose M, et al. PRDM16 co-operates with LHX2 to shape the human brain. bioRxiv. 2023;: pubmed publisher
Li J, Godoy M, Zhang A, Diamante G, Ahn I, Cebrian Silla A, et al. Prdm16 and Vcam1 regulate the postnatal disappearance of embryonic radial glia and the ending of cortical neurogenesis. bioRxiv. 2023;: pubmed publisher
Wang Q, Li H, Tajima K, Verkerke A, Taxin Z, Hou Z, et al. Post-translational control of beige fat biogenesis by PRDM16 stabilization. Nature. 2022;609:151-158 pubmed publisher
Yan C, Lin J, Huang Y, Gao Q, Piao Z, Yuan S, et al. Population genomics reveals that natural variation in PRDM16 contributes to cold tolerance in domestic cattle. Zool Res. 2022;43:275-284 pubmed publisher
Choi K, Kim J, Kong X, Isik M, Zhang J, Lim H, et al. Defective brown adipose tissue thermogenesis and impaired glucose metabolism in mice lacking Letmd1. Cell Rep. 2021;37:110104 pubmed publisher
Chi J, Lin Z, Barr W, Crane A, Zhu X, Cohen P. Early postnatal interactions between beige adipocytes and sympathetic neurites regulate innervation of subcutaneous fat. elife. 2021;10: pubmed publisher
Su L, Lei X, Ma H, Feng C, Jiang J, Jiao J. PRDM16 orchestrates angiogenesis via neural differentiation in the developing brain. Cell Death Differ. 2020;27:2313-2329 pubmed publisher
Zheng S, Guo S, Sun G, Shi Y, Wei Z, Tang Y, et al. Gain of Metabolic Benefit with Ablation of miR-149-3p from Subcutaneous Adipose Tissue in Diet-Induced Obese Mice. Mol Ther Nucleic Acids. 2019;18:194-203 pubmed publisher
Lau W, Noruddin N, Ariffin A, Mahmud M, Noor M, Amanah A, et al. Novel discovery of Averrhoa bilimbi ethanolic leaf extract in the stimulation of brown fat differentiation program in combating diet-induced obesity. BMC Complement Altern Med. 2019;19:243 pubmed publisher
Liao J, Jiang J, Jun H, Qiao X, Emont M, Kim D, et al. HDAC3-Selective Inhibition Activates Brown and Beige Fat Through PRDM16. Endocrinology. 2018;159:2520-2527 pubmed publisher
Chen Q, Huang L, Pan D, Zhu L, Wang Y. Cbx4 Sumoylates Prdm16 to Regulate Adipose Tissue Thermogenesis. Cell Rep. 2018;22:2860-2872 pubmed publisher
Groman Lupa S, Adewumi J, Park K, Brzezinski J. The Transcription Factor Prdm16 Marks a Single Retinal Ganglion Cell Subtype in the Mouse Retina. Invest Ophthalmol Vis Sci. 2017;58:5421-5433 pubmed publisher
Bauters D, Cobbaut M, Geys L, Van Lint J, Hemmeryckx B, Lijnen H. Loss of ADAMTS5 enhances brown adipose tissue mass and promotes browning of white adipose tissue via CREB signaling. Mol Metab. 2017;6:715-724 pubmed publisher
Huang L, Pan D, Chen Q, Zhu L, Ou J, Wabitsch M, et al. Transcription factor Hlx controls a systematic switch from white to brown fat through Prdm16-mediated co-activation. Nat Commun. 2017;8:68 pubmed publisher
Ding H, Zheng S, Garcia Ruiz D, Hou D, Wei Z, Liao Z, et al. Fasting induces a subcutaneous-to-visceral fat switch mediated by microRNA-149-3p and suppression of PRDM16. Nat Commun. 2016;7:11533 pubmed publisher

product information

brand :

R&D Systems

master code :

AF6295

SKU :

AF6295

product name :

Human/Mouse PRDM16/MEL1 Antibody

unit size :

100 ug (also 25 ug)

seo description :

The Human/Mouse PRDM16/MEL1 Antibody from R&D Systems is a sheep polyclonal antibody to PRDM16/MEL1. This antibody reacts with human,mouse,transgenic mouse. The Human/Mouse PRDM16/MEL1 Antibody has been validated for the following applications: Co-Immunoprecipitation,Immunohistochemistry,Immunoprecipitation,Western Blot,Screening,Immunohistochemistry-Frozen,Chromatin Immunoprecipitation (ChIP).

target :

PRDM16/MEL1

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Polyclonal

concentration :

LYOPH

conjugate :

Unconjugated

dilution :

Western Blot 1 ug/mL, Immunohistochemistry 5-15 ug/mL

host :

Sheep

immunogen :

E. coli -derived recombinant mouse PRDM16, Lys537-Glu688, Accession # A2A935.1

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Human,Mouse,Transgenic Mouse

specificity :

Detects mouse and human PRDM16 in direct ELISAs and Western blots.

gene symbol :

PRDM16

top caption :

Detection of Human PRDM16 antibody by Western Blot.

accessionNumbers :

A2A935.1

applications :

Co-Immunoprecipitation,Screening,Immunohistochemistry,Immunoprecipitation,Western Blot,Immunohistochemistry-Frozen,Chromatin Immunoprecipitation (ChIP)

USD :

489 USD

alt names :

MDS1/EVI1-like gene 1, MEL1, MEL1KIAA1675PFM13MGC166915, PFM13, PR domain containing 16, PR domain zinc finger protein 16, PR domain-containing protein 16, Transcription factor MEL1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage