product summary
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company name :
R&D Systems
product type :
antibody
product name :
C. difficile Toxin B/TcdB Antibody
catalog :
AF6246
quantity :
100 ug (also 25 ug)
price :
469 USD
clonality :
polyclonal
host :
domestic sheep
conjugate :
nonconjugated
reactivity :
Clostridioides difficile 630
application :
western blot, immunocytochemistry
more info or order :
R&D Systems product webpage
citations: 6
Reference
Siddiqi U, Lunnemann H, Childress K, Shupe J, Rutherford S, Farrow M, et al. Inhibition of EGFR/ErbB does not protect against C. difficile toxin B. bioRxiv. 2024;: pubmed publisher
Ahmed U, Shadid T, Larabee J, Ballard J. Combined and Distinct Roles of Agr Proteins in Clostridioides difficile 630 Sporulation, Motility, and Toxin Production. MBio. 2020;11: pubmed publisher
Tam J, Icho S, Utama E, Orrell K, Gómez Biagi R, Theriot C, et al. Intestinal bile acids directly modulate the structure and function of C. difficile TcdB toxin. Proc Natl Acad Sci U S A. 2020;117:6792-6800 pubmed publisher
Tam J, Hamza T, Ma B, Chen K, Beilhartz G, Ravel J, et al. Host-targeted niclosamide inhibits C. difficile virulence and prevents disease in mice without disrupting the gut microbiota. Nat Commun. 2018;9:5233 pubmed publisher
Hunt J, Larabee J, Ballard J. Amino Acid Differences in the 1753-to-1851 Region of TcdB Influence Variations in TcdB1 and TcdB2 Cell Entry. mSphere. 2017;2: pubmed publisher
Larabee J, Bland S, Hunt J, Ballard J. Intrinsic Toxin-Derived Peptides Destabilize and Inactivate Clostridium difficile TcdB. MBio. 2017;8: pubmed publisher
product information
brand :
R&D Systems
catalog number base :
AF6246
SKU :
AF6246
product name :
C. difficile Toxin B/TcdB Antibody
units size :
100 ug (also 25 ug)
description :
The C. difficile Toxin B/TcdB Antibody from R&D Systems is a sheep polyclonal antibody to Toxin B/TcdB. This antibody reacts with c. difficile,hamster,human,hamster - cricetulus (chinese hamster). The C. difficile Toxin B/TcdB Antibody has been validated for the following applications: Western Blot,Immunocytochemistry.
target :
Toxin B/TcdB
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
clonality :
Polyclonal
concentration :
LYOPH
conjugate :
Unconjugated
all_available conjugate :
Unconjugated
host :
Sheep
immunogen :
E. coli -derived recombinant C. difficile Toxin B/TcdB, Ser2-Leu543, Accession # P18177
isotype :
IgG
purity :
Antigen Affinity-purified
species :
C. difficile,Hamster,Human,Hamster - Cricetulus (Chinese Hamster)
specificity :
Detects C. difficile Toxin B/TcdB in direct ELISAs and Western blots.
gene symbol :
tcdB
top caption :
Detection of C. difficile Toxin B/TcdB antibody by Western Blot.
accessionNumbers :
P18177
applications :
Western Blot,Immunocytochemistry
USD :
469 USD
alt names :
toxB
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.