product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human Angiopoietin-2 Antibody
catalog :
AF623
quantity :
100 ug (also 25 ug)
price :
499 USD
clonality :
polyclonal
host :
domestic goat
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, neutralization, immunohistochemistry - paraffin section
more info or order :
R&D Systems product webpage
citations: 16
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; 1:200; loading ...; fig 1e
Hultstr xf6 m M, Fromell K, Larsson A, Persson B, Nilsson B, Quaggin S, et al. Angiopoietin-2 Inhibition of Thrombomodulin-Mediated Anticoagulation-A Novel Mechanism That May Contribute to Hypercoagulation in Critically Ill COVID-19 Patients. Biomedicines. 2022;10: pubmed publisher
  • immunohistochemistry - paraffin section; human; loading ...; fig 5f
Fawkner Corbett D, Antanaviciute A, Parikh K, Jagielowicz M, Gerós A, Gupta T, et al. Spatiotemporal analysis of human intestinal development at single-cell resolution. Cell. 2021;184:810-826.e23 pubmed publisher
Roos Mattila M, Kaprio T, Mustonen H, Hagstr xf6 m J, Saharinen P, Haglund C, et al. The possible dual role of Ang-2 in the prognosis of pancreatic cancer. Sci Rep. 2023;13:18725 pubmed publisher
Schrenk S, Bischoff L, Goines J, Cai Y, Vemaraju S, Odaka Y, et al. MEK inhibition reduced vascular tumor growth and coagulopathy in a mouse model with hyperactive GNAQ. Nat Commun. 2023;14:1929 pubmed publisher
Lasagni S, Leonardi F, Pivetti A, Di Marco L, Ravaioli F, Serenari M, et al. Endothelial angiopoietin-2 overexpression in explanted livers identifies subjects at higher risk of recurrence of hepatocellular carcinoma after liver transplantation. Front Oncol. 2022;12:960808 pubmed publisher
Choe Y, Yoon J, Joo J, Kim B, Hong S, Koh G, et al. Pericyte Loss Leads to Capillary Stalling Through Increased Leukocyte-Endothelial Cell Interaction in the Brain. Front Cell Neurosci. 2022;16:848764 pubmed publisher
Winkler E, Kim C, Ross J, Garcia J, Gil E, Oh I, et al. A single-cell atlas of the normal and malformed human brain vasculature. Science. 2022;375:eabi7377 pubmed publisher
Pape T, Idowu T, Etzrodt V, Stahl K, Seeliger B, Haller H, et al. Modulation of the Permeability-Inducing Factor Angiopoietin-2 Through Bifonazole in Systemic Inflammation. Shock. 2021;56:1049-1056 pubmed publisher
Villa E, Critelli R, Lasagni S, Melegari A, Curatolo A, Celsa C, et al. Dynamic angiopoietin-2 assessment predicts survival and chronic course in hospitalized patients with COVID-19. Blood Adv. 2021;5:662-673 pubmed publisher
Cha B, Ho Y, Geng X, Mahamud M, Chen L, Kim Y, et al. YAP and TAZ maintain PROX1 expression in the developing lymphatic and lymphovenous valves in response to VEGF-C signaling. Development. 2020;147: pubmed publisher
Tiemeier G, de Koning R, Wang G, Kostidis S, Rietjens R, Sol W, et al. Lowering the increased intracellular pH of human-induced pluripotent stem cell-derived endothelial cells induces formation of mature Weibel-Palade bodies. Stem Cells Transl Med. 2020;9:758-772 pubmed publisher
Mahamud M, Geng X, Ho Y, Cha B, Kim Y, Ma J, et al. GATA2 controls lymphatic endothelial cell junctional integrity and lymphovenous valve morphogenesis through miR-126. Development. 2019;146: pubmed publisher
Lin C, Cho C, Bai S, Liu J, Kuo T, Wang L, et al. ADAM9 promotes lung cancer progression through vascular remodeling by VEGFA, ANGPT2, and PLAT. Sci Rep. 2017;7:15108 pubmed publisher
Retzlaff J, Thamm K, Ghosh C, Ziegler W, Haller H, Parikh S, et al. Flunarizine suppresses endothelial Angiopoietin-2 in a calcium - dependent fashion in sepsis. Sci Rep. 2017;7:44113 pubmed publisher
Jenny Zhou H, Qin L, Zhang H, Tang W, Ji W, He Y, et al. Endothelial exocytosis of angiopoietin-2 resulting from CCM3 deficiency contributes to cerebral cavernous malformation. Nat Med. 2016;22:1033-1042 pubmed publisher
Rautiola J, Lampinen A, Mirtti T, Ristimaki A, Joensuu H, Bono P, et al. Association of Angiopoietin-2 and Ki-67 Expression with Vascular Density and Sunitinib Response in Metastatic Renal Cell Carcinoma. PLoS ONE. 2016;11:e0153745 pubmed publisher
product information
brand :
R&D Systems
master code :
AF623
SKU :
AF623
product name :
Human Angiopoietin-2 Antibody
unit size :
100 ug (also 25 ug)
seo description :
The Human Angiopoietin-2 Antibody from R&D Systems is a goat polyclonal antibody to Angiopoietin-2. This antibody reacts with human,mouse. The Human Angiopoietin-2 Antibody has been validated for the following applications: Immunohistochemistry,Western Blot,Neutralization,Immunohistochemistry-Paraffin,Immunocytochemistry.
target :
Angiopoietin-2
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Polyclonal
concentration :
LYOPH
conjugate :
Unconjugated
dilution :
Western Blot 1 ug/mL, Immunohistochemistry 5-15 ug/mL
host :
Goat
immunogen :
Mouse myeloma cell line NS0-derived recombinant human Angiopoietin-2, Asp68-Phe496, Accession # O15123
isotype :
IgG
purity :
Antigen Affinity-purified
species :
Human,Mouse
specificity :
Detects human Angiopoietin-2 in direct ELISAs and Western blots. In direct ELISAs, 100% cross-reactivity with recombinant mouse Angiopoietin-2 is observed and less than 5% cross-reactivity with recombinant human Angiopoietin-1 is observed.
gene symbol :
ANGPT2
top caption :
Detection of Human Angiopoietin-2 antibody by Western Blot.
accessionNumbers :
O15123
applications :
Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Neutralization,Immunocytochemistry
USD :
499 USD
alt names :
AGPT2, ANG2, ANG-2, angiopoietin 2, angiopoietin-2, angiopoietin-2a, angiopoietin-2B, angiopoitin 2, ANGPT2, Tie2-ligand
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.