Human Tie-1 Antibody | R&D Systems AF619 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human Tie-1 Antibody

catalog :

AF619

quantity :

100 ug (also 25 ug)

price :

489 USD

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunoprecipitation, flow cytometry

more info or order :

R&D Systems product webpage

citations: 8

Published Application/Species/Sample/Dilution	Reference
western blot; human; loading ...; fig 6c, s5	Hsieh L, Dos Santos S, Hall B, Ogbechi J, Loglo A, Salguero F, et al. Aberrant stromal tissue factor localisation and mycolactone-driven vascular dysfunction, exacerbated by IL-1β, are linked to fibrin formation in Buruli ulcer lesions. PLoS Pathog. 2022;18:e1010280 pubmed publisher
immunoprecipitation; human; loading ...; fig s6c western blot; human; loading ...; fig s6c	LeppÃ¤nen V, Saharinen P, Alitalo K. Structural basis of Tie2 activation and Tie2/Tie1 heterodimerization. Proc Natl Acad Sci U S A. 2017;114:4376-4381 pubmed publisher
	Sato Nishiuchi R, Doiguchi M, Morooka N, Sekiguchi K. Polydom/SVEP1 binds to Tie1 and promotes migration of lymphatic endothelial cells. J Cell Biol. 2023;222: pubmed publisher
	Choe Y, Yoon J, Joo J, Kim B, Hong S, Koh G, et al. Pericyte Loss Leads to Capillary Stalling Through Increased Leukocyte-Endothelial Cell Interaction in the Brain. Front Cell Neurosci. 2022;16:848764 pubmed publisher
	Griffin M, Sorum A, Miller G, Goddard W, Hsieh Wilson L. Sulfated glycans engage the Ang-Tie pathway to regulate vascular development. Nat Chem Biol. 2021;17:178-186 pubmed publisher
	Qu X, Violette K, Sewell Loftin M, Soslow J, Saint Jean L, Hinton R, et al. Loss of flow responsive Tie1 results in Impaired Aortic valve remodeling. Dev Biol. 2019;455:73-84 pubmed publisher
	Morooka N, Futaki S, Sato Nishiuchi R, Nishino M, Totani Y, Shimono C, et al. Polydom Is an Extracellular Matrix Protein Involved in Lymphatic Vessel Remodeling. Circ Res. 2017;120:1276-1288 pubmed publisher
	Hakanpaa L, Sipilä T, Leppänen V, Gautam P, Nurmi H, Jacquemet G, et al. Endothelial destabilization by angiopoietin-2 via integrin Î²1 activation. Nat Commun. 2015;6:5962 pubmed publisher

product information

master code :

AF619

SKU :

AF619

product name :

Human Tie-1 Antibody

unit size :

100 ug (also 25 ug)

description :

The Human Tie-1 Antibody from R&D Systems is a goat polyclonal antibody to Tie-1. This antibody reacts with human,mouse. The Human Tie-1 Antibody has been validated for the following applications: Flow Cytometry,Immunoprecipitation,Western Blot,Immunohistochemistry,CyTOF-ready.

target :

Tie-1

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Polyclonal

concentration :

LYOPH

conjugate :

Unconjugated

host :

Goat

immunogen :

Mouse myeloma cell line NS0-derived recombinant human Tie-1, Ala22-Gln760, Accession # P35590

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Human,Mouse

specificity :

Detects human Tie-1 in direct ELISAs and Western blots. In direct ELISAs, approximately 50% cross-reactivity with recombinant mouse Tie-1 is observed and less than 1% cross-reactivity with recombinant human Tie-2 is observed.

gene symbol :

TIE1

top caption :

Detection of Tie-1 antibody in HUVEC Human Cells antibody by Flow Cytometry.

accessionNumbers :

P35590

applications :

Flow Cytometry,Immunoprecipitation,Western Blot,Immunohistochemistry,CyTOF-ready

USD :

489 USD

alt names :

EC 2.7.10, EC 2.7.10.1, JTK14soluble TIE1 variant 3, receptor tyrosine kinase, soluble TIE1 variant 1, soluble TIE1 variant 2, soluble TIE1 variant 5, Tie1, TIEsoluble TIE1 variant 4, tyrosine kinase with immunoglobulin and epidermal growth factor homologydomains 1, tyrosine kinase with immunoglobulin-like and EGF-like domains 1, tyrosine-protein kinase receptor Tie-1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage