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company name :
R&D Systems
product type :
antibody
product name :
Rat Jagged 1 Antibody
catalog :
AF599
quantity :
100 ug (also 25 ug)
price :
489 USD
clonality :
polyclonal
host :
domestic goat
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, neutralization, flow cytometry, immunohistochemistry - frozen section
more info or order :
R&D Systems product webpage
citations: 17
Reference
Shi M, Crouse B, Sundaram N, Pode Shakked N, Ester L, Zhang W, et al. Integrating collecting systems in kidney organoids through fusion of distal nephron to ureteric bud. bioRxiv. 2024;: pubmed publisher
Schnell J, Miao Z, Achieng M, Fausto C, Wang V, Kuyper F, et al. Stepwise developmental mimicry generates proximal-biased kidney organoids. bioRxiv. 2024;: pubmed publisher
Liu J, Prahl L, Huang A, Hughes A. Measurement of adhesion and traction of cells at high yield (MATCHY) reveals an energetic ratchet driving nephron condensation. bioRxiv. 2024;: pubmed publisher
Suda N, Bartolom xe9 A, Liang J, Son J, Yagishita Y, Siebel C, et al. β-cell Jagged1 is sufficient but not necessary for islet Notch activity and insulin secretory defects in obese mice. Mol Metab. 2024;81:101894 pubmed publisher
Rios Coronado P, Zanetti D, Zhou J, Naftaly J, Prabala P, Mart xed nez Jaimes A, et al. CXCL12 drives natural variation in coronary artery anatomy across diverse populations. medRxiv. 2024;: pubmed publisher
Ristori T, Thuret R, Hooker E, Quicke P, Lanthier K, Ntumba K, et al. Bmp9 regulates Notch signaling and the temporal dynamics of angiogenesis via Lunatic Fringe. bioRxiv. 2023;: pubmed publisher
Maunsell H, Ellis K, Kelley M, Driver E. Lrrn1 Regulates Medial Boundary Formation in the Developing Mouse Organ of Corti. J Neurosci. 2023;43:5305-5318 pubmed publisher
Lawrence M, Elhendawi M, Morlock M, Liu W, Liu S, Palakkan A, et al. Human iPSC-derived renal organoids engineered to report oxidative stress can predict drug-induced toxicity. iScience. 2022;25:103884 pubmed publisher
Azzoni E, Frontera V, Anselmi G, Rode C, James C, Deltcheva E, et al. The onset of circulation triggers a metabolic switch required for endothelial to hematopoietic transition. Cell Rep. 2021;37:110103 pubmed publisher
Yu J, Zhu C, Wang X, Kim K, Bartolomé A, Dongiovanni P, et al. Hepatocyte TLR4 triggers inter-hepatocyte Jagged1/Notch signaling to determine NASH-induced fibrosis. Sci Transl Med. 2021;13: pubmed publisher
Guo Q, Kim A, Li B, Ransick A, Bugacov H, Chen X, et al. A β-catenin-driven switch in TCF/LEF transcription factor binding to DNA target sites promotes commitment of mammalian nephron progenitor cells. elife. 2021;10: pubmed publisher
Viallard C, Audiger C, Popovic N, Akla N, Lanthier K, Legault Navarrete I, et al. BMP9 signaling promotes the normalization of tumor blood vessels. Oncogene. 2020;39:2996-3014 pubmed publisher
Ransick A, Lindström N, Liu J, Zhu Q, Guo J, Alvarado G, et al. Single-Cell Profiling Reveals Sex, Lineage, and Regional Diversity in the Mouse Kidney. Dev Cell. 2019;51:399-413.e7 pubmed publisher
Wiszniak S, Schwarz Q. Notch signalling defines dorsal root ganglia neuroglial fate choice during early neural crest cell migration. BMC Neurosci. 2019;20:21 pubmed publisher
Verma M, Asakura Y, Murakonda B, Pengo T, Latroche C, Chazaud B, et al. Muscle Satellite Cell Cross-Talk with a Vascular Niche Maintains Quiescence via VEGF and Notch Signaling. Cell Stem Cell. 2018;23:530-543.e9 pubmed publisher
Poduri A, Chang A, Raftrey B, Rhee S, Van M, Red Horse K. Endothelial cells respond to the direction of mechanical stimuli through SMAD signaling to regulate coronary artery size. Development. 2017;144:3241-3252 pubmed publisher
Ola R, Dubrac A, Han J, Zhang F, Fang J, Larrivee B, et al. PI3 kinase inhibition improves vascular malformations in mouse models of hereditary haemorrhagic telangiectasia. Nat Commun. 2016;7:13650 pubmed publisher
product information
master code :
AF599
SKU :
AF599
product name :
Rat Jagged 1 Antibody
unit size :
100 ug (also 25 ug)
description :
The Rat Jagged 1 Antibody from R&D Systems is a goat polyclonal antibody to Jagged 1. This antibody reacts with human,mouse,rat,transgenic mouse. The Rat Jagged 1 Antibody has been validated for the following applications: Immunocytochemistry,Immunohistochemistry,IHC-F,Flow Cytometry,Western Blot,Neutralization,ELISA Capture (Matched Antibody Pair),CyTOF-ready.
target :
Jagged 1
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Polyclonal
conjugate :
Unconjugated
host :
Goat
immunogen :
Mouse myeloma cell line NS0-derived recombinant rat Jagged 1, Ser32-Asp1068 (Gly57-Arg59 del, Asp63Thr, Arg64Leu, and Val-Arg-Pro-Tyr ins before Lys69), Accession # Q63722
isotype :
IgG
purity :
Antigen Affinity-purified
species :
Human,Mouse,Rat,Transgenic Mouse
specificity :
Detects rat Jagged 1 in ELISAs and Western blots. In sandwich ELISAs, approximately 15% cross-reactivity with recombinant human (rh) Jagged 1 is observed, and less than 0.3% cross-reactivity with rhJagged 2 and recombinant mouse Jagged 2 is observed.
gene symbol :
JAG1
endotoxin note :
<0.10 EU per 1 ╡g of the antibody by the LAL method.
top caption :
Differentiation Induced by Jagged 1 and Neutralization by Rat Jagged 1 Antibody.
accessionNumbers :
Q63722
applications :
Immunocytochemistry,Immunohistochemistry,IHC-F,Flow Cytometry,Western Blot,Neutralization,ELISA Capture (Matched Antibody Pair),CyTOF-ready
USD :
489 USD
alt names :
AGS, AHDMGC104644, Alagille syndrome, AWS, CD339, CD339 antigen, HJ1, JAG1, jagged 1, Jagged1, JAGL1, protein jagged-1
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.