Human ST6 Gal Sialyltransferase 1/ ST6GAL1 Antibody | R&D Systems AF5924 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human ST6 Gal Sialyltransferase 1/ ST6GAL1 Antibody

catalog :

AF5924

quantity :

100 ug (also 25 ug)

price :

499 USD

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

R&D Systems product webpage

citations: 23

Reference
Dashzeveg N, Jia Y, Zhang Y, Gerratana L, Patel P, Shajahan A, et al. Dynamic Glycoprotein Hyposialylation Promotes Chemotherapy Evasion and Metastatic Seeding of Quiescent Circulating Tumor Cell Clusters in Breast Cancer. Cancer Discov. 2023;13:2050-2071 pubmed publisher
Van Coillie J, Pongrácz T, Rahm xf6 ller J, Chen H, Geyer C, van Vught L, et al. The BNT162b2 mRNA SARS-CoV-2 vaccine induces transient afucosylated IgG1 in naive but not in antigen-experienced vaccinees. EBioMedicine. 2023;87:104408 pubmed publisher
Zou X, Lu J, Deng Y, Liu Q, Yan X, Cui Y, et al. ST6GAL1 inhibits metastasis of hepatocellular carcinoma via modulating sialylation of MCAM on cell surface. Oncogene. 2023;42:516-529 pubmed publisher
Makarava N, Katorcha E, Chang J, Lau J, Baskakov I. Deficiency in ST6GAL1, one of the two α2,6-sialyltransferases, has only a minor effect on the pathogenesis of prion disease. Front Mol Biosci. 2022;9:1058602 pubmed publisher
Gc S, Tuy K, Rickenbacker L, Jones R, Chakraborty A, Miller C, et al. α2,6 Sialylation mediated by ST6GAL1 promotes glioblastoma growth. JCI Insight. 2022;7: pubmed publisher
Hait N, Maiti A, Wu R, Andersen V, Hsu C, Wu Y, et al. Extracellular sialyltransferase st6gal1 in breast tumor cell growth and invasiveness. Cancer Gene Ther. 2022;29:1662-1675 pubmed publisher
Zhang M, Qi T, Yang L, Kolarich D, Heisterkamp N. Multi-Faceted Effects of ST6Gal1 Expression on Precursor B-Lineage Acute Lymphoblastic Leukemia. Front Oncol. 2022;12:828041 pubmed publisher
Smithson M, Irwin R, Williams G, Alexander K, Smythies L, Nearing M, et al. Sialyltransferase ST6GAL-1 mediates resistance to chemoradiation in rectal cancer. J Biol Chem. 2022;298:101594 pubmed publisher
Holdbrooks A, Ankenbauer K, Hwang J, Bellis S. Regulation of inflammatory signaling by the ST6Gal-I sialyltransferase. PLoS ONE. 2020;15:e0241850 pubmed publisher
Britain C, Bhalerao N, Silva A, Chakraborty A, Buchsbaum D, Crowley M, et al. Glycosyltransferase ST6Gal-I promotes the epithelial to mesenchymal transition in pancreatic cancer cells. J Biol Chem. 2021;296:100034 pubmed publisher
Alexander K, Serrano C, Chakraborty A, Nearing M, Council L, Riquelme A, et al. Modulation of glycosyltransferase ST6Gal-I in gastric cancer-derived organoids disrupts homeostatic epithelial cell turnover. J Biol Chem. 2020;295:14153-14163 pubmed publisher
Ou L, He X, Liu N, Song Y, Li J, Gao L, et al. Sialylation of FGFR1 by ST6Gal‑I overexpression contributes to ovarian cancer cell migration and chemoresistance. Mol Med Rep. 2020;21:1449-1460 pubmed publisher
Dorsett K, Jones R, Ankenbauer K, Hjelmeland A, Bellis S. Sox2 promotes expression of the ST6Gal-I glycosyltransferase in ovarian cancer cells. J Ovarian Res. 2019;12:93 pubmed publisher
Zhang Q, Higginbotham J, Jeppesen D, Yang Y, Li W, McKinley E, et al. Transfer of Functional Cargo in Exomeres. Cell Rep. 2019;27:940-954.e6 pubmed publisher
Zhou X, Kinlough C, Hughey R, Jin M, Inoue H, Etling E, et al. Sialylation of MUC4β N-glycans by ST6GAL1 orchestrates human airway epithelial cell differentiation associated with type-2 inflammation. JCI Insight. 2019;4: pubmed publisher
Mayr J, Lau K, Lai J, Gagarinov I, Shi Y, McAtamney S, et al. Unravelling the Role of O-glycans in Influenza A Virus Infection. Sci Rep. 2018;8:16382 pubmed publisher
Schulz M, Tian W, Mao Y, Van Coillie J, Sun L, Larsen J, et al. Glycoengineering design options for IgG1 in CHO cells using precise gene editing. Glycobiology. 2018;28:542-549 pubmed publisher
Jones R, Dorsett K, Hjelmeland A, Bellis S. The ST6Gal-I sialyltransferase protects tumor cells against hypoxia by enhancing HIF-1α signaling. J Biol Chem. 2018;293:5659-5667 pubmed publisher
Britain C, Holdbrooks A, Anderson J, Willey C, Bellis S. Sialylation of EGFR by the ST6Gal-I sialyltransferase promotes EGFR activation and resistance to gefitinib-mediated cell death. J Ovarian Res. 2018;11:12 pubmed publisher
Holdbrooks A, Britain C, Bellis S. ST6Gal-I sialyltransferase promotes tumor necrosis factor (TNF)-mediated cancer cell survival via sialylation of the TNF receptor 1 (TNFR1) death receptor. J Biol Chem. 2018;293:1610-1622 pubmed publisher
Chakraborty A, Dorsett K, Trummell H, Yang E, Oliver P, Bonner J, et al. ST6Gal-I sialyltransferase promotes chemoresistance in pancreatic ductal adenocarcinoma by abrogating gemcitabine-mediated DNA damage. J Biol Chem. 2018;293:984-994 pubmed publisher
Jones M, Oswald D, Joshi S, Whiteheart S, Orlando R, Cobb B. B-cell-independent sialylation of IgG. Proc Natl Acad Sci U S A. 2016;113:7207-12 pubmed publisher
Schultz M, Holdbrooks A, Chakraborty A, Grizzle W, Landen C, Buchsbaum D, et al. The Tumor-Associated Glycosyltransferase ST6Gal-I Regulates Stem Cell Transcription Factors and Confers a Cancer Stem Cell Phenotype. Cancer Res. 2016;76:3978-88 pubmed publisher

product information

brand :

R&D Systems

master code :

AF5924

SKU :

AF5924

product name :

Human ST6 Gal Sialyltransferase 1/ ST6GAL1 Antibody

unit size :

100 ug (also 25 ug)

seo description :

The Human ST6 Gal Sialyltransferase 1/ ST6GAL1 Antibody from R&D Systems is a goat polyclonal antibody to ST6 Gal Sialyltransferase 1/ST6GAL1/CD75. This antibody reacts with hamster,human,mouse,transgenic mouse. The Human ST6 Gal Sialyltransferase 1/ ST6GAL1 Antibody has been validated for the following applications: Western Blot,Immunocytochemistry,Flow Cytometry,Immunohistochemistry,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Simple Western.

target :

ST6 Gal Sialyltransferase 1/ST6GAL1

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Polyclonal

concentration :

LYOPH

conjugate :

Unconjugated

dilution :

Western Blot 1 ug/mL, Simple Western 10 ug/mL, Immunohistochemistry 0.3-15 ug/mL, Immunocytochemistry 5-15 ug/mL

host :

Goat

immunogen :

Mouse myeloma cell line NS0-derived recombinant human ST6 Gal Sialyltransferase 1/ST6GAL1, Lys27-Cys406, Accession # P15907

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Hamster,Human,Mouse

specificity :

Detects human ST6 Gal Sialyltransferase 1/ST6GAL1 in direct ELISAs and Western blots.

gene symbol :

ST6GAL1

top caption :

Detection of Human ST6GAL1 antibody by Western Blot.

accessionNumbers :

P15907

applications :

Simple Western,Flow Cytometry,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry

USD :

499 USD

alt names :

Alpha 2,6-ST, B-cell antigen CD75, beta-galactoside alpha-2,6-sialyltransferase 1, CD75, CMP-N-acetylneuraminate beta-galactosamide alpha-2,6-sialyltransferase, CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1, EC 2.4.99.1, MGC48859, Sialyltransferase 1, sialyltransferase 1 (beta-galactoside alpha-2,6-sialyltransferase), sialyltransferase 1 (beta-galactoside alpha-2,6-sialytransferase), SIAT1, SIAT1Alpha 2,6-ST 1, ST6 beta-galactosamide alpha-2,6-sialyltranferase 1, ST6Gal I, ST6GalI, ST6N

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage