Mouse/Rat Neurocan Antibody | R&D Systems AF5800 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Mouse/Rat Neurocan Antibody

catalog :

AF5800

quantity :

100 ug (also 25 ug)

price :

489 USD

clonality :

polyclonal

host :

domestic sheep

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

R&D Systems product webpage

citations: 14

Reference
Otsuka M, Essel L, Sinha A, Nickerson G, Mejia S, Matthews R, et al. The hyaluronan-binding activity of aggrecan is important, but not essential, for its specific insertion into perineuronal nets. bioRxiv. 2024;: pubmed publisher
Kuczynski Noyau L, Karmann S, Alberton P, Martínez Corral I, Nampoothiri S, Sauv xe9 F, et al. A plastic aggrecan barrier modulated by peripheral energy state gates metabolic signal access to arcuate neurons. Nat Commun. 2024;15:6701 pubmed publisher
Irala D, Wang S, Sakers K, Nagendren L, Ulloa Severino F, Bindu D, et al. Astrocyte-Secreted Neurocan Controls Inhibitory Synapse Formation and Function. bioRxiv. 2023;: pubmed publisher
H xf6 hn L, Hu xdf ler W, Richter A, Smalla K, Birkl Toeglhofer A, Birkl C, et al. Extracellular Matrix Changes in Subcellular Brain Fractions and Cerebrospinal Fluid of Alzheimer's Disease Patients. Int J Mol Sci. 2023;24: pubmed publisher
Ritok A, Kiss P, Zaher A, Wolf E, Ducza L, Bacskai T, et al. Distribution and postnatal development of chondroitin sulfate proteoglycans in the perineuronal nets of cholinergic motoneurons innervating extraocular muscles. Sci Rep. 2022;12:21606 pubmed publisher
Hu xdf ler W, H xf6 hn L, Stolz C, Vielhaber S, Garz C, Schmitt F, et al. Brevican and Neurocan Cleavage Products in the Cerebrospinal Fluid - Differential Occurrence in ALS, Epilepsy and Small Vessel Disease. Front Cell Neurosci. 2022;16:838432 pubmed publisher
Schmidt S, Holzer M, Arendt T, Sonntag M, Morawski M. Tau Protein Modulates Perineuronal Extracellular Matrix Expression in the TauP301L-acan Mouse Model. Biomolecules. 2022;12: pubmed publisher
Heusinger J, Hildebrandt H, Illing R. Sensory deafferentation modulates and redistributes neurocan in the rat auditory brainstem. Brain Behav. 2019;9:e01353 pubmed publisher
Fontanil T, Mohamedi Y, Moncada Pazos A, Cobo T, Vega J, Cobo J, et al. Neurocan is a New Substrate for the ADAMTS12 Metalloprotease: Potential Implications in Neuropathies. Cell Physiol Biochem. 2019;52:1003-1016 pubmed publisher
Ueno H, Suemitsu S, Murakami S, Kitamura N, Wani K, Matsumoto Y, et al. Layer-specific expression of extracellular matrix molecules in the mouse somatosensory and piriform cortices. IBRO Rep. 2019;6:1-17 pubmed publisher
Sonntag M, Blosa M, Schmidt S, Reimann K, Blum K, Eckrich T, et al. Synaptic coupling of inner ear sensory cells is controlled by brevican-based extracellular matrix baskets resembling perineuronal nets. BMC Biol. 2018;16:99 pubmed publisher
Chen J, Van Gulden S, McGuire T, Fleming A, Oka C, Kessler J, et al. BMP-Responsive Protease HtrA1 Is Differentially Expressed in Astrocytes and Regulates Astrocytic Development and Injury Response. J Neurosci. 2018;38:3840-3857 pubmed publisher
Ueno H, Suemitsu S, Okamoto M, Matsumoto Y, Ishihara T. Sensory experience-dependent formation of perineuronal nets and expression of Cat-315 immunoreactive components in the mouse somatosensory cortex. Neuroscience. 2017;355:161-174 pubmed publisher
Bartels M, Winterhalter P, Yu J, Liu Y, Lommel M, Möhrlen F, et al. Protein O-Mannosylation in the Murine Brain: Occurrence of Mono-O-Mannosyl Glycans and Identification of New Substrates. PLoS ONE. 2016;11:e0166119 pubmed publisher

product information

master code :

AF5800

SKU :

AF5800

product name :

Mouse/Rat Neurocan Antibody

unit size :

100 ug (also 25 ug)

description :

The Mouse/Rat Neurocan Antibody from R&D Systems is a sheep polyclonal antibody to Neurocan. This antibody reacts with human,mouse,rat,transgenic mouse. The Mouse/Rat Neurocan Antibody has been validated for the following applications: Western Blot,Immunocytochemistry,Immunohistochemistry,ELISA Development,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen.

target :

Neurocan

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Polyclonal

concentration :

LYOPH

conjugate :

Unconjugated

host :

Sheep

immunogen :

Chinese hamster ovary cell line CHO-derived recombinant mouse Neurocan, Asp23-Asp637, Accession # NP_031815

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Human,Mouse,Rat,Transgenic Mouse

specificity :

Detects mouse and rat Neurocan in direct ELISAs and Western blots.

gene symbol :

Ncan

top caption :

Detection of Mouse/Rat Neurocan antibody by Western Blot.

accessionNumbers :

NP_031815

applications :

Western Blot,Immunocytochemistry,Immunohistochemistry,ELISA Development,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen

USD :

489 USD

alt names :

Chondroitin sulfate proteoglycan 3, chondroitin sulfate proteoglycan 3 (neurocan), CSPG3, CSPG3neurocan core protein, FLJ44681, NCAN, NEUR, neurocan, neurocan proteoglycan

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage