product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human p16INK4a/ CDKN2A Antibody
catalog :
AF5779
quantity :
100 ug (also 25 ug)
price :
479 USD
clonality :
polyclonal
host :
domestic goat
conjugate :
nonconjugated
reactivity :
human
application :
western blot, immunohistochemistry, immunocytochemistry
more info or order :
R&D Systems product webpage
citations: 13
Reference
Featherby S, Faulkner E, Ettelaie C. Tissue factor signalling modifies the expression and regulation of G1/S checkpoint regulators: Implications during injury and prolonged inflammation. Mol Med Rep. 2025;31: pubmed publisher
Herdy J, Traxler L, Agarwal R, Karbacher L, Schlachetzki J, Boehnke L, et al. Increased post-mitotic senescence in aged human neurons is a pathological feature of Alzheimer's disease. Cell Stem Cell. 2022;29:1637-1652.e6 pubmed publisher
Zimmermann T, Pommer M, Kluge V, Chiheb C, Muehlich S, Bosserhoff A. Detection of Cellular Senescence in Human Primary Melanocytes and Malignant Melanoma Cells In Vitro. Cells. 2022;11: pubmed publisher
Farfariello V, Gordienko D, Mesilmany L, Touil Y, Germain E, Fliniaux I, et al. TRPC3 shapes the ER-mitochondria Ca2+ transfer characterizing tumour-promoting senescence. Nat Commun. 2022;13:956 pubmed publisher
Mathiasen S, Gall Mas L, Pateras I, Theodorou S, Namini M, Hansen M, et al. Bacterial genotoxins induce T cell senescence. Cell Rep. 2021;35:109220 pubmed publisher
Schwartz R, Shokhirev M, Andrade L, Gutkind J, Iglesias Bartolomé R, Shadel G. Insights into epithelial cell senescence from transcriptome and secretome analysis of human oral keratinocytes. Aging (Albany NY). 2021;13:4747-4777 pubmed publisher
Sachamitr P, Ho J, Ciamponi F, Ba Alawi W, Coutinho F, Guilhamon P, et al. PRMT5 inhibition disrupts splicing and stemness in glioblastoma. Nat Commun. 2021;12:979 pubmed publisher
Lin R, Rahtu Korpela L, Magga J, Ulvila J, Swan J, Kemppi A, et al. miR-1468-3p Promotes Aging-Related Cardiac Fibrosis. Mol Ther Nucleic Acids. 2020;20:589-605 pubmed publisher
Vijayaraj P, Minasyan A, Durra A, Karumbayaram S, Mehrabi M, Aros C, et al. Modeling Progressive Fibrosis with Pluripotent Stem Cells Identifies an Anti-fibrotic Small Molecule. Cell Rep. 2019;29:3488-3505.e9 pubmed publisher
Wang J, Yao Y, Zhang Q, Li S, Tang L. Inflammatory responses induced by Helicobacter pylori on the carcinogenesis of gastric epithelial GES‑1 cells. Int J Oncol. 2019;54:2200-2210 pubmed publisher
Choi S, Bin B, Kim W, Lee E, Lee T, Cho E. Exposure of human melanocytes to UVB twice and subsequent incubation leads to cellular senescence and senescence-associated pigmentation through the prolonged p53 expression. J Dermatol Sci. 2018;90:303-312 pubmed publisher
Schaefer I, Wang Y, Liang C, Bahri N, Quattrone A, Doyle L, et al. MAX inactivation is an early event in GIST development that regulates p16 and cell proliferation. Nat Commun. 2017;8:14674 pubmed publisher
Jin T, Kim M, Heo W, Park K, Choi S, Lee M, et al. Adiponectin corrects premature cellular senescence and normalizes antimicrobial peptide levels in senescent keratinocytes. Biochem Biophys Res Commun. 2016;477:678-684 pubmed publisher
product information
master code :
AF5779
SKU :
AF5779
product name :
Human p16INK4a/ CDKN2A Antibody
unit size :
100 ug (also 25 ug)
description :
The Human p16INK4a/ CDKN2A Antibody from R&D Systems is a goat polyclonal antibody to p16INK4a/CDKN2A. This antibody reacts with human. The Human p16INK4a/ CDKN2A Antibody has been validated for the following applications: Immunocytochemistry,Western Blot,Simple Western,Immunohistochemistry.
target :
p16INK4a / CDKN2A
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Polyclonal
concentration :
LYOPH
conjugate :
Unconjugated
host :
Goat
immunogen :
E. coli -derived recombinant human p16INK4a/CDKN2A, Glu2-Asp156, Accession # P42771
isotype :
IgG
purity :
Antigen Affinity-purified
species :
Human
specificity :
Detects human p16INK4a/CDKN2A in Western blots.
gene symbol :
CDKN2A
top caption :
Detection of Human p16INK4a/CDKN2A antibody by Western Blot.
accessionNumbers :
P42771
applications :
Immunocytochemistry,Western Blot,Simple Western,Immunohistochemistry
USD :
479 USD
alt names :
ARF, CDK4 inhibitor p16-INK4, CDK4I, CDK4IP14ARF, CDKN2, CDKN2A, cell cycle negative regulator beta, CMM2P16-INK4A, Cyclin-dependent kinase 4 inhibitor A, cyclin-dependent kinase inhibitor 2A, cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4), INK4, INK4A, MLM, MLMP16INK4, MTS-1, MTS1P14, Multiple tumor suppressor 1, p14, p14ARF, p16, p16-INK4, p16INK4a, p16-INK4a, P19, p19ARF, TP16
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.