product summary
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company name :
R&D Systems
product type :
antibody
product name :
Rat MuSK Antibody
catalog :
AF562
quantity :
100 ug (also 25 ug)
price :
499 USD
clonality :
polyclonal
host :
domestic goat
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunocytochemistry, neutralization, immunoprecipitation
more info or order :
R&D Systems product webpage
citations: 9
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; loading ...; fig 1g
Oury J, Zhang W, Leloup N, Koide A, Corrado A, Ketavarapu G, et al. Mechanism of disease and therapeutic rescue of Dok7 congenital myasthenia. Nature. 2021;595:404-408 pubmed publisher
Cao M, Liu W, Maxwell S, Huda S, Webster R, Evoli A, et al. IgG1-3 MuSK Antibodies Inhibit AChR Cluster Formation, Restored by SHP2 Inhibitor, Despite Normal MuSK, DOK7, or AChR Subunit Phosphorylation. Neurol Neuroimmunol Neuroinflamm. 2023;10: pubmed publisher
Lim J, Augustinus R, Plomp J, Roya Kouchaki K, Vergoossen D, Filli xe9 Grijpma Y, et al. Development and characterization of agonistic antibodies targeting the Ig-like 1 domain of MuSK. Sci Rep. 2023;13:7478 pubmed publisher
Huda S, Cao M, De Rosa A, Woodhall M, Rodríguez Cruz P, Cossins J, et al. SHP2 inhibitor protects AChRs from effects of myasthenia gravis MuSK antibody. Neurol Neuroimmunol Neuroinflamm. 2020;7: pubmed publisher
Takata K, Stathopoulos P, Cao M, Mané Damas M, Fichtner M, Benotti E, et al. Characterization of pathogenic monoclonal autoantibodies derived from muscle-specific kinase myasthenia gravis patients. JCI Insight. 2019;4: pubmed publisher
Huijbers M, Vergoossen D, Fillié Grijpma Y, van Es I, Koning M, Slot L, et al. MuSK myasthenia gravis monoclonal antibodies: Valency dictates pathogenicity. Neurol Neuroimmunol Neuroinflamm. 2019;6:e547 pubmed publisher
Huda S, Waters P, Woodhall M, Leite M, Jacobson L, De Rosa A, et al. IgG-specific cell-based assay detects potentially pathogenic MuSK-Abs in seronegative MG. Neurol Neuroimmunol Neuroinflamm. 2017;4:e357 pubmed publisher
Miyoshi S, Tezuka T, Arimura S, Tomono T, Okada T, Yamanashi Y. DOK7 gene therapy enhances motor activity and life span in ALS model mice. EMBO Mol Med. 2017;9:880-889 pubmed publisher
Vezina Audette R, Tremblay M, Carbonetto S. Laminin is instructive and calmodulin dependent kinase II is non-permissive for the formation of complex aggregates of acetylcholine receptors on myotubes in culture. Matrix Biol. 2017;57-58:106-123 pubmed publisher
product information
brand :
R&D Systems
master code :
AF562
SKU :
AF562
product name :
Rat MuSK Antibody
unit size :
100 ug (also 25 ug)
seo description :
The Rat MuSK Antibody from R&D Systems is a goat polyclonal antibody to MuSK. This antibody reacts with human,mouse,rat. The Rat MuSK Antibody has been validated for the following applications: Immunoprecipitation,Western Blot,Neutralization,Immunocytochemistry.
target :
MuSK
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Polyclonal
concentration :
LYOPH
conjugate :
Unconjugated
dilution :
Western Blot 0.1 ug/mL, Neutralization 0.5-2 ug/mL
host :
Goat
immunogen :
Mouse myeloma cell line NS0-derived recombinant rat MuSK
isotype :
IgG
purity :
Antigen Affinity-purified
species :
Human,Mouse,Rat
specificity :
Detects rat MuSK in direct ELISAs and Western blots.
gene symbol :
MUSK
endotoxin note :
<0.10 EU per 1 ╡g of the antibody by the LAL method.
top caption :
Acetylcholine Receptor Clustering Mediated by MuSK and Neutralization by Rat MuSK Antibody.
applications :
Immunoprecipitation,Western Blot,Neutralization,Immunocytochemistry
USD :
499 USD
alt names :
EC 2.7.10, EC 2.7.10.1, MGC126323, MGC126324, muscle, skeletal, receptor tyrosine kinase, MuSK, skeletal receptor tyrosine-protein kinase
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.