Human SGPL1 Antibody | R&D Systems AF5535 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human SGPL1 Antibody

catalog :

AF5535

quantity :

100 ug (also 25 ug)

price :

469 USD

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

more info or order :

R&D Systems product webpage

citations: 11

Reference
Khan R, Oskouian B, Lee J, Hodgin J, Yang Y, Tassew G, et al. AAV-SPL 2.0, a Modified Adeno-Associated Virus Gene Therapy Agent for the Treatment of Sphingosine Phosphate Lyase Insufficiency Syndrome. Int J Mol Sci. 2023;24: pubmed publisher
Yildirim A, Citir M, Dogan A, Veli Z, Yıldırım Z, Tufanlı Ö, et al. ER Stress-Induced Sphingosine-1-Phosphate Lyase Phosphorylation Potentiates the Mitochondrial Unfolded Protein Response. J Lipid Res. 2022;63:100279 pubmed publisher
de la Garza Rodea A, Moore S, Zamora Pineda J, Hoffman E, Mistry K, Kumar A, et al. Sphingosine Phosphate Lyase Is Upregulated in Duchenne Muscular Dystrophy, and Its Inhibition Early in Life Attenuates Inflammation and Dystrophy in Mdx Mice. Int J Mol Sci. 2022;23: pubmed publisher
Maharaj A, Guran T, Buonocore F, Achermann J, Metherell L, Prasad R, et al. Insights From Long-term Follow-up of a Girl With Adrenal Insufficiency and Sphingosine-1-Phosphate Lyase Deficiency. J Endocr Soc. 2022;6:bvac020 pubmed publisher
Zhao P, Tassew G, Lee J, Oskouian B, Muñoz D, Hodgin J, et al. Efficacy of AAV9-mediated SGPL1 gene transfer in a mouse model of S1P lyase insufficiency syndrome. JCI Insight. 2021;6: pubmed publisher
Maharaj A, Williams J, Bradshaw T, G xfc ran T, Braslavsky D, Casas J, et al. Sphingosine-1-phosphate lyase (SGPL1) deficiency is associated with mitochondrial dysfunction. J Steroid Biochem Mol Biol. 2020;202:105730 pubmed publisher
Takahashi K, Fujiya M, Konishi H, Murakami Y, Iwama T, Sasaki T, et al. Heterogenous Nuclear Ribonucleoprotein H1 Promotes Colorectal Cancer Progression through the Stabilization of mRNA of Sphingosine-1-Phosphate Lyase 1. Int J Mol Sci. 2020;21: pubmed publisher
Maharaj A, Theodorou D, Banerjee I, Metherell L, Prasad R, Wallace D. A Sphingosine-1-Phosphate Lyase Mutation Associated With Congenital Nephrotic Syndrome and Multiple Endocrinopathy. Front Pediatr. 2020;8:151 pubmed publisher
Taylor V, Stone H, Schuh M, Zhao X, SETCHELL K, Erkan E. Disarranged Sphingolipid Metabolism From Sphingosine-1-Phosphate Lyase Deficiency Leads to Congenital Nephrotic Syndrome. Kidney Int Rep. 2019;4:1763-1769 pubmed publisher
Yamaguchi D, Imaizumi T, Yagi K, Matsumoto Y, Nakashima T, Hirose A, et al. Nicotinamide phosphoribosyltransferase is a molecular target of potent anticancer agents identified from phenotype-based drug screening. Sci Rep. 2019;9:7742 pubmed publisher
Lovric S, Gonçalves S, Gee H, Oskouian B, Srinivas H, Choi W, et al. Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency. J Clin Invest. 2017;127:912-928 pubmed publisher

product information

master code :

AF5535

SKU :

AF5535

product name :

Human SGPL1 Antibody

unit size :

100 ug (also 25 ug)

description :

The Human SGPL1 Antibody from R&D Systems is a goat polyclonal antibody to SGPL1. This antibody reacts with human,mouse,rat. The Human SGPL1 Antibody has been validated for the following applications: Western Blot,Immunohistochemistry,Immunohistochemistry-Paraffin,Simple Western.

target :

SGPL1

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Polyclonal

concentration :

LYOPH

conjugate :

Unconjugated

host :

Goat

immunogen :

E. coli -derived recombinant human SGPL1, Lys342-His568, Accession # O95470

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Human,Mouse,Rat

specificity :

Detects human SGPL1 in direct ELISAs and Western blots.

gene symbol :

SGPL1

top caption :

Detection of Human SGPL1 antibody by Western Blot.

accessionNumbers :

O95470

applications :

Western Blot,Immunohistochemistry,Immunohistochemistry-Paraffin,Simple Western

USD :

469 USD

alt names :

EC 4.1.2.27, FLJ13811, hSPL, KIAA1252, S1PL, Sphingosine-1-phosphate aldolase, sphingosine-1-phosphate lyase 1, SPL, SPLSPL 1, SP-lyase, SP-lyase 1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage