product summary
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company name :
R&D Systems
product type :
antibody
product name :
Rat CX3CL1/Fractalkine Chemokine Domain Antibody
catalog :
AF537
quantity :
100 ug (also 25 ug)
price :
499 USD
clonality :
polyclonal
host :
domestic goat
conjugate :
nonconjugated
reactivity :
mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, neutralization, immunohistochemistry - paraffin section
more info or order :
R&D Systems product webpage
citations: 6
Reference
Sun P, Lin W, Weng Y, Gong J, Huang Y, Tang Y, et al. Spinal Cathepsin S promotes visceral hypersensitivity via FKN/CX3CR1/p38 MAPK signaling pathways. Mol Pain. 2023;19:17448069231179118 pubmed publisher
Shen Y, Cui J, Zhang S, Wang Y, Wang J, Su Y, et al. Temporal alteration of microglia to microinfarcts in rat brain induced by the vascular occlusion with fluorescent microspheres. Front Cell Neurosci. 2022;16:956342 pubmed publisher
Mao M, Xu Y, Zhang X, Yang L, An X, Qu Y, et al. MicroRNA-195 prevents hippocampal microglial/macrophage polarization towards the M1 phenotype induced by chronic brain hypoperfusion through regulating CX3CL1/CX3CR1 signaling. J Neuroinflammation. 2020;17:244 pubmed publisher
Castro Sánchez S, García Yagüe A, López Royo T, Casarejos M, Lanciego J, Lastres Becker I. Cx3cr1-deficiency exacerbates alpha-synuclein-A53T induced neuroinflammation and neurodegeneration in a mouse model of Parkinson's disease. Glia. 2018;66:1752-1762 pubmed publisher
Madrigal J, Caso J, Garcia Bueno B, Gutiérrez I, Leza J. Noradrenaline induces CX3CL1 production and release by neurons. Neuropharmacology. 2017;114:146-155 pubmed publisher
Yeh P, Huang H, Yang C, Yang W, Yang C. Astaxanthin Inhibits Expression of Retinal Oxidative Stress and Inflammatory Mediators in Streptozotocin-Induced Diabetic Rats. PLoS ONE. 2016;11:e0146438 pubmed publisher
product information
master code :
AF537
SKU :
AF537
product name :
Rat CX3CL1/Fractalkine Chemokine Domain Antibody
unit size :
100 ug (also 25 ug)
description :
The Rat CX3CL1/Fractalkine Chemokine Domain Antibody from R&D Systems is a goat polyclonal antibody to CX3CL1/Fractalkine. This antibody reacts with mouse,rat,transgenic mouse. The Rat CX3CL1/Fractalkine Chemokine Domain Antibody has been validated for the following applications: Immunohistochemistry,In vivo assay,Western Blot,Neutralization,Immunohistochemistry-Paraffin,Immunocytochemistry,ELISA Capture (Matched Antibody Pair).
target :
CX3CL1/Fractalkine
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Polyclonal
concentration :
LYOPH
conjugate :
Unconjugated
host :
Goat
immunogen :
E. coli -derived recombinant rat CX3CL1/Fractalkine, Gln25-Gly100, Accession # O55145
isotype :
IgG
purity :
Antigen Affinity-purified
species :
Mouse,Rat,Transgenic Mouse
specificity :
Detects rat CX3CL1/Fractalkine in ELISAs and Western blots. Neutralizes the biological activity of recombinant human CX3CL1 and recombinant mouse CX3CL1 with similar effectiveness.
gene symbol :
CX3CL1
endotoxin note :
<0.10 EU per 1 ╡g of the antibody by the LAL method.
top caption :
Chemotaxis Induced by CX3CL1/Fractalkine and Neutralization by Rat CX3CL1/Fractalkine Antibody.
accessionNumbers :
O55145
applications :
Immunohistochemistry,In vivo assay,Western Blot,Neutralization,Immunohistochemistry-Paraffin,Immunocytochemistry,ELISA Capture (Matched Antibody Pair)
USD :
499 USD
alt names :
ABCD-3, C3Xkine, chemokine (C-X3-C motif) ligand 1, CX3C membrane-anchored chemokine, CXC3, CXC3C, FKN, fractalkine, Neurotactin, neurotactin), NTNsmall inducible cytokine subfamily D (Cys-X3-Cys), member 1 (fractalkine, NTTSmall-inducible cytokine D1, SCYD1C-X3-C motif chemokine 1, small inducible cytokine subfamily D (Cys-X3-Cys), member-1
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.