product summary
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company name :
R&D Systems
product type :
antibody
product name :
Mouse uPAR Antibody
catalog :
AF534
quantity :
100 ug (also 25 ug)
price :
499 USD
clonality :
polyclonal
host :
domestic goat
conjugate :
nonconjugated
reactivity :
mouse, bovine
application :
western blot, immunohistochemistry, immunocytochemistry, neutralization, immunoprecipitation, flow cytometry, immunohistochemistry - frozen section
more info or order :
R&D Systems product webpage
citations: 11
Reference
Zhang L, Li Y, Kibler K, Kraberger S, Varsani A, Turk J, et al. Viral anti-inflammatory serpin reduces immuno-coagulopathic pathology in SARS-CoV-2 mouse models of infection. EMBO Mol Med. 2023;15:e17376 pubmed publisher
Guo Q, Yaron J, Wallen J, Browder K, Boyd R, Olson T, et al. PEGylated Serp-1 Markedly Reduces Pristane-Induced Experimental Diffuse Alveolar Hemorrhage, Altering uPAR Distribution, and Macrophage Invasion. Front Cardiovasc Med. 2021;8:633212 pubmed publisher
Amor C, Feucht J, Leibold J, Ho Y, Zhu C, Alonso Curbelo D, et al. Senolytic CAR T cells reverse senescence-associated pathologies. Nature. 2020;583:127-132 pubmed publisher
Jing Y, Chávez V, Khatwani N, Ban Y, Espejo A, Chen X, et al. In vivo antitumor activity by dual stromal and tumor-targeted oncolytic measles viruses. Cancer Gene Ther. 2020;27:910-922 pubmed publisher
Pontecorvi P, Banki M, Zampieri C, Zalfa C, Azmoon P, Kounnas M, et al. Fibrinolysis protease receptors promote activation of astrocytes to express pro-inflammatory cytokines. J Neuroinflammation. 2019;16:257 pubmed publisher
Zhang L, Yaron J, Tafoya A, Wallace S, Kilbourne J, HAYDEL S, et al. A Virus-Derived Immune Modulating Serpin Accelerates Wound Closure with Improved Collagen Remodeling. J Clin Med. 2019;8: pubmed publisher
Harel E, Shoji J, Abraham V, Miller L, Laszik Z, King A, et al. Further Evidence That the Soluble Urokinase Plasminogen Activator Receptor Does Not Directly Injure Mice or Human Podocytes. Transplantation. 2020;104:54-60 pubmed publisher
Wei C, Li J, Adair B, Zhu K, Cai J, Merchant M, et al. uPAR isoform 2 forms a dimer and induces severe kidney disease in mice. J Clin Invest. 2019;129:1946-1959 pubmed publisher
Magnussen S, Hadler Olsen E, Costea D, Berg E, Jacobsen C, Mortensen B, et al. Cleavage of the urokinase receptor (uPAR) on oral cancer cells: regulation by transforming growth factor - β1 (TGF-β1) and potential effects on migration and invasion. BMC Cancer. 2017;17:350 pubmed publisher
Merino P, Diaz A, Jeanneret V, Wu F, Torre E, Cheng L, et al. Urokinase-type Plasminogen Activator (uPA) Binding to the uPA Receptor (uPAR) Promotes Axonal Regeneration in the Central Nervous System. J Biol Chem. 2017;292:2741-2753 pubmed publisher
Spinale J, Mariani L, Kapoor S, Zhang J, Weyant R, Song P, et al. A reassessment of soluble urokinase-type plasminogen activator receptor in glomerular disease. Kidney Int. 2015;87:564-74 pubmed publisher
product information
master code :
AF534
SKU :
AF534
product name :
Mouse uPAR Antibody
unit size :
100 ug (also 25 ug)
description :
The Mouse uPAR Antibody from R&D Systems is a goat polyclonal antibody to uPAR. This antibody reacts with bovine,mouse,transgenic mouse. The Mouse uPAR Antibody has been validated for the following applications: Western Blot,Immunohistochemistry,ELISA Development (Detection),Flow Cytometry,Immunoprecipitation,Neutralization,Immunohistochemistry-Frozen,In vivo assay,Immunocytochemistry,Blockade of Receptor-ligand Interaction,CyTOF-ready.
target :
uPAR
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Polyclonal
concentration :
LYOPH
conjugate :
Unconjugated
host :
Goat
immunogen :
Mouse myeloma cell line NS0-derived recombinant mouse uPAR isoform 1, Leu24-Thr297, Accession # Q545X5
isotype :
IgG
purity :
Antigen Affinity-purified
species :
Bovine,Mouse,Transgenic Mouse
specificity :
Detects mouse uPAR in direct ELISAs and Western blots.
gene symbol :
PLAUR
endotoxin note :
<0.10 EU per 1 ╡g of the antibody by the LAL method.
Antibody validation :
Knockout/Knockdown
top caption :
uPAR antibody in Mouse Kidney by Immunohistochemistry (IHC-Fr).
accessionNumbers :
Q545X5
applications :
Immunohistochemistry,ELISA Development (Detection),Flow Cytometry,Immunoprecipitation,Western Blot,Neutralization,Immunohistochemistry-Frozen,In vivo assay,Immunocytochemistry,Blockade of Receptor-ligand Interaction,CyTOF-ready
USD :
499 USD
alt names :
CD87, CD87 antigen, Monocyte activation antigen Mo3, plasminogen activator, urokinase receptor, PLAUR, uPAR, U-PAR, UPARurokinase plasminogen activator surface receptor, u-plasminogen activator receptor form 2, URKRMO3
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.