Human/Mouse/Rat Phospho-FRS2 (Y436) Antibody | R&D Systems AF5126 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human/Mouse/Rat Phospho-FRS2 (Y436) Antibody

catalog :

AF5126

quantity :

100 ug (also 25 ug)

price :

409 USD

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, neutralization, immunohistochemistry - paraffin section

more info or order :

R&D Systems product webpage

citations: 8

Reference
Brandi G, Relli V, Deserti M, Palloni A, Indio V, Astolfi A, et al. Activated FGFR2 signalling as a biomarker for selection of intrahepatic cholangiocarcinoma patients candidate to FGFR targeted therapies. Sci Rep. 2024;14:3136 pubmed publisher
An S, Mohanty J, Tomé F, Suzuki Y, Lax I, Schlessinger J. Heparin is essential for optimal cell signaling by FGF21 and for regulation of βKlotho cellular stability. Proc Natl Acad Sci U S A. 2023;120:e2219128120 pubmed publisher
Park J, Choi J, Cao L, Mohanty J, Suzuki Y, Park A, et al. Isoform-specific inhibition of FGFR signaling achieved by a de-novo-designed mini-protein. Cell Rep. 2022;41:111545 pubmed publisher
Zhang Y, Wu T, Li F, Cheng Y, Han Q, Lu X, et al. FGF19 Is Coamplified With CCND1 to Promote Proliferation in Lung Squamous Cell Carcinoma and Their Combined Inhibition Shows Improved Efficacy. Front Oncol. 2022;12:846744 pubmed publisher
Xiang H, Chan A, Ahene A, Bellovin D, Deng R, Hsu A, et al. Preclinical characterization of bemarituzumab, an anti-FGFR2b antibody for the treatment of cancer. MAbs. 2021;13:1981202 pubmed publisher
Liu P, Koblish H, Wu L, Bowman K, Diamond S, Dimatteo D, et al. INCB054828 (pemigatinib), a potent and selective inhibitor of fibroblast growth factor receptors 1, 2, and 3, displays activity against genetically defined tumor models. PLoS ONE. 2020;15:e0231877 pubmed publisher
Xu L, Meng X, Xu N, Fu W, Tan H, Zhang L, et al. Gambogenic acid inhibits fibroblast growth factor receptor signaling pathway in erlotinib-resistant non-small-cell lung cancer and suppresses patient-derived xenograft growth. Cell Death Dis. 2018;9:262 pubmed publisher
Kabashima A, Hirsova P, Bronk S, Hernandez M, Truty M, Rizvi S, et al. Fibroblast growth factor receptor inhibition induces loss of matrix MCL1 and necrosis in cholangiocarcinoma. J Hepatol. 2018;68:1228-1238 pubmed publisher

product information

brand :

R&D Systems

master code :

AF5126

SKU :

AF5126

product name :

Human/Mouse/Rat Phospho-FRS2 (Y436) Antibody

unit size :

100 ug (also 25 ug)

seo description :

The Human/Mouse/Rat Phospho-FRS2 (Y436) Antibody from R&D Systems is a rabbit polyclonal antibody to FRS2. This antibody reacts with human,mouse,rat,hamster - cricetulus (chinese hamster). The Human/Mouse/Rat Phospho-FRS2 (Y436) Antibody has been validated for the following applications: Western Blot,Immunohistochemistry,Neutralization,Immunohistochemistry-Paraffin,Immunocytochemistry.

target :

FRS2

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Polyclonal

concentration :

LYOPH

conjugate :

Unconjugated

dilution :

Western Blot 1 ug/mL, Immunocytochemistry 5-15 ug/mL

host :

Rabbit

immunogen :

Phosphopeptide containing human FRS2 Y436 site

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Human,Mouse,Rat,Hamster - Cricetulus (Chinese Hamster)

specificity :

Detects human, mouse, and rat FRS2 isoforms when phosphorylated at Y436.

gene symbol :

FRS2

top caption :

Detection of Human and Rat Phospho-FRS2 (Y436) antibody by Western Blot.

applications :

Immunocytochemistry,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Neutralization

USD :

409 USD

alt names :

FGFR signalling adaptor, FGFR-signaling adaptor SNT, fibroblast growth factor receptor substrate 2, FRS2A, FRS2alpha, SNT, SNT1, SNT-1FGFR substrate 2, Suc1-associated neurotrophic factor target 1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage