Rat IL-6 Antibody | R&D Systems AF506 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Rat IL-6 Antibody

catalog :

AF506

quantity :

100 ug (also 25 ug)

price :

499 USD

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, neutralization, immunohistochemistry - frozen section

more info or order :

R&D Systems product webpage

citations: 29

Reference
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Loureiro A, Moura Neto L, Martins C, Silva P, Lopes M, Leit xe3 o R, et al. Role of Pannexin-1-P2X7R signaling on cell death and pro-inflammatory mediator expression induced by Clostridioides difficile toxins in enteric glia. Front Immunol. 2022;13:956340 pubmed publisher
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Wang Z, Xia Y, Wu Z, Kang S, Zhang J, Liu P, et al. Neuronal ApoE4 stimulates C/EBPβ activation, promoting Alzheimer's disease pathology in a mouse model. Prog Neurobiol. 2022;209:102212 pubmed publisher
Feng Y, Li X, Wang J, Huang X, Meng L, Huang J. Pyruvate kinase M2 (PKM2) improve symptoms of post-ischemic stroke depression by activating VEGF to mediate the MAPK/ERK pathway. Brain Behav. 2022;12:e2450 pubmed publisher
Wareham L, Echevarria F, Sousa J, Konlian D, Dallas G, Formichella C, et al. Interleukin-6 promotes microtubule stability in axons via Stat3 protein-protein interactions. iScience. 2021;24:103141 pubmed publisher
Yergoz F, Friebel J, Krankel N, Rauch Kroehnert U, Schultheiss H, Landmesser U, et al. Adenine Nucleotide Translocase 1 Expression Modulates the Immune Response in Ischemic Hearts. Cells. 2021;10: pubmed publisher
Dong J, Viswanathan S, Adami E, Schafer S, Kuthubudeen F, Widjaja A, et al. The pro-regenerative effects of hyperIL6 in drug-induced liver injury are unexpectedly due to competitive inhibition of IL11 signaling. elife. 2021;10: pubmed publisher
George M, Jasmin N, Cummings V, Richard Loendt A, Launchbury F, Woollard K, et al. Selective Interleukin-6 Trans-Signaling Blockade Is More Effective Than Panantagonism in Reperfused Myocardial Infarction. JACC Basic Transl Sci. 2021;6:431-443 pubmed publisher
Wang Z, Xia Y, Liu P, Liu X, Edgington Mitchell L, Lei K, et al. ApoE4 activates C/EBPβ/δ-secretase with 27-hydroxycholesterol, driving the pathogenesis of Alzheimer's disease. Prog Neurobiol. 2021;202:102032 pubmed publisher
Dong J, Viswanathan S, Adami E, Singh B, Chothani S, Ng B, et al. Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH. Nat Commun. 2021;12:66 pubmed publisher
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Ding H, Dai Y, Lei Y, Wang Z, Liu D, Li R, et al. Upregulation of CD81 in trophoblasts induces an imbalance of Treg/Th17 cells by promoting IL-6 expression in preeclampsia. Cell Mol Immunol. 2019;16:302-312 pubmed publisher
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product information

brand :

R&D Systems

master code :

AF506

SKU :

AF506

product name :

Rat IL-6 Antibody

unit size :

100 ug (also 25 ug)

seo description :

The Rat IL-6 Antibody from R&D Systems is a goat polyclonal antibody to IL-6. This antibody reacts with human,mouse,rat. The Rat IL-6 Antibody has been validated for the following applications: Bioassay,Fuorescense Microscopy,Immunodepletion,Western Blot,Neutralization,Immunohistochemistry,Immunohistochemistry-Frozen,In vivo assay,Immunocytochemistry.

target :

IL-6

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Polyclonal

concentration :

LYOPH

conjugate :

Unconjugated

dilution :

Western Blot 1 ug/mL, Neutralization 0.5 ug/mL, Immunocytochemistry 5-15 ug/mL

host :

Goat

immunogen :

E. coli -derived recombinant rat IL-6, Phe25-Thr211, Accession # P20607

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Human,Mouse,Rat

specificity :

Detects rat and mouse IL-6 in direct ELISAs and Western blots. In direct ELISAs, approximately 10% cross-reactivity with recombinant cotton rat IL-6 is observed, and less than 1% cross-reactivity with recombinant human IL-6 is observed.

gene symbol :

IL6

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

top caption :

Detection of Rat IL-6 antibody by Western Blot.

accessionNumbers :

P20607

applications :

Bioassay,Fuorescense Microscopy,Immunodepletion,Immunohistochemistry,Western Blot,Immunohistochemistry-Frozen,In vivo assay,Neutralization,Immunocytochemistry

USD :

499 USD

alt names :

B-cell differentiation factor, B-cell stimulatory factor 2, BSF2, BSF-2, CDF, CTL differentiation factor, HSF, hybridoma growth factor, IFNB2, IFN-beta-2, IL6, IL-6, Interferon beta-2, interleukin 6 (interferon, beta 2), interleukin BSF-2, interleukin-6, MGI-2A

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage