Mouse Leptin/OB Antibody | R&D Systems AF498 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Mouse Leptin/OB Antibody

catalog :

AF498

quantity :

100 ug (also 25 ug)

price :

519 USD

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

mouse

application :

western blot, ELISA, immunohistochemistry, neutralization, immunohistochemistry - frozen section

more info or order :

R&D Systems product webpage

citations: 15

Reference
Qu J, Fu S, Yin L, Zhang Q, Wang X. Chemerin influences blood lipid of aged male mice under high fat diet and exercise states through regulating the distribution and browning of white adipose tissue. Cytokine. 2024;181:156689 pubmed publisher
Gogiraju R, Witzler C, Shahneh F, Hubert A, Renner L, Bochenek M, et al. Deletion of endothelial leptin receptors in mice promotes diet-induced obesity. Sci Rep. 2023;13:8276 pubmed publisher
Chen Y, Chien C, Hsu C, Lee C, Chou Y, Shiah S, et al. Obesity-associated leptin promotes chemoresistance in colorectal cancer through YAP-dependent AXL upregulation. Am J Cancer Res. 2021;11:4220-4240 pubmed
Leibiger B, Moede T, Valladolid Acebes I, Paschen M, Visa M, Leibiger I, et al. Ectopic Leptin Production by Intraocular Pancreatic Islet Organoids Ameliorates the Metabolic Phenotype of ob/ob Mice. Metabolites. 2021;11: pubmed publisher
Guan H, Zheng H, Zhang J, Xiang A, Li Y, Zheng H, et al. Secreted frizzled-related protein 4 promotes brown adipocyte differentiation. Exp Ther Med. 2021;21:637 pubmed publisher
Fisch S, Bachner Hinenzon N, Ertracht O, Guo L, Arad Y, Ben Zvi D, et al. Localized Antileptin Therapy Prevents Aortic Root Dilatation and Preserves Left Ventricular Systolic Function in a Murine Model of Marfan Syndrome. J Am Heart Assoc. 2020;9:e014761 pubmed publisher
Zhang C, Yue C, Herrmann A, Song J, Egelston C, Wang T, et al. STAT3 Activation-Induced Fatty Acid Oxidation in CD8+ T Effector Cells Is Critical for Obesity-Promoted Breast Tumor Growth. Cell Metab. 2020;31:148-161.e5 pubmed publisher
Frodermann V, Rohde D, Courties G, Severe N, Schloss M, Amatullah H, et al. Exercise reduces inflammatory cell production and cardiovascular inflammation via instruction of hematopoietic progenitor cells. Nat Med. 2019;25:1761-1771 pubmed publisher
Rivadeneira D, DePeaux K, Wang Y, Kulkarni A, Tabib T, Menk A, et al. Oncolytic Viruses Engineered to Enforce Leptin Expression Reprogram Tumor-Infiltrating T Cell Metabolism and Promote Tumor Clearance. Immunity. 2019;51:548-560.e4 pubmed publisher
John B, Naczki C, Patel C, Ghoneum A, Qasem S, Salih Z, et al. Regulation of the bi-directional cross-talk between ovarian cancer cells and adipocytes by SPARC. Oncogene. 2019;38:4366-4383 pubmed publisher
Tenvooren I, Jenks M, Rashid H, Cook K, Muhlemann J, Sistrunk C, et al. Elevated leptin disrupts epithelial polarity and promotes premalignant alterations in the mammary gland. Oncogene. 2019;38:3855-3870 pubmed publisher
Nozaki C, Nent E, Bilkei Gorzo A, Zimmer A. Involvement of leptin signaling in the development of cannabinoid CB2 receptor-dependent mirror image pain. Sci Rep. 2018;8:10827 pubmed publisher
Zeng Q, Luo X, Han M, Liu W, Li H. Leptin/Osteopontin Axis Regulated Type 2T Helper Cell Response in Allergic Rhinitis with Obesity. EBioMedicine. 2018;32:43-49 pubmed publisher
Chang K, Lin Y, Lin C, Tsai M, Huang W, Shih Y, et al. Data on the expression of leptin and leptin receptor in the dorsal root ganglion and spinal cord after preganglionic cervical root avulsion. Data Brief. 2017;15:567-572 pubmed publisher
Matoba K, Muramatsu R, Yamashita T. Leptin sustains spontaneous remyelination in the adult central nervous system. Sci Rep. 2017;7:40397 pubmed publisher

product information

master code :

AF498

SKU :

AF498

product name :

Mouse Leptin/OB Antibody

unit size :

100 ug (also 25 ug)

description :

The Mouse Leptin/OB Antibody from R&D Systems is a goat polyclonal antibody to Leptin/OB. This antibody reacts with mouse,transgenic mouse. The Mouse Leptin/OB Antibody has been validated for the following applications: Western Blot,ELISA Development,Neutralization,Immunohistochemistry,Immunohistochemistry-Frozen,In vivo assay,ELISA Capture (Matched Antibody Pair).

target :

Leptin/OB

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Polyclonal

concentration :

LYOPH

conjugate :

Unconjugated

host :

Goat

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Mouse,Transgenic Mouse

specificity :

Detects mouse Leptin/OB in ELISAs and Western blots.

gene symbol :

LEP

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

top caption :

Leptin/OB antibody in Mouse Brain by Immunohistochemistry (IHC-Fr).

accessionNumbers :

Q544U0

applications :

Western Blot,ELISA Development,Neutralization,Immunohistochemistry,Immunohistochemistry-Frozen,In vivo assay,ELISA Capture (Matched Antibody Pair)

USD :

519 USD

alt names :

FLJ94114, LEP, leptin, leptin (murine obesity homolog), leptin (obesity homolog, mouse), OB, Obese protein, obese, mouse, homolog of, Obesity factor, OBOBS

storage :

Store the unopened product at -20 to -70 ░C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

more info or order :

R&D Systems product webpage