Human CLEC14A Antibody | R&D Systems AF4968 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human CLEC14A Antibody

catalog :

AF4968

quantity :

100 ug (also 25 ug)

price :

499 USD

clonality :

polyclonal

host :

domestic sheep

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, neutralization, flow cytometry, immunohistochemistry - paraffin section

more info or order :

R&D Systems product webpage

citations: 5

Reference
Zhuang X, Maione F, Robinson J, Bentley M, Kaul B, Whitworth K, et al. CAR T cells targeting tumor endothelial marker CLEC14A inhibit tumor growth. JCI Insight. 2020;5: pubmed publisher
Robinson J, Whitworth K, Jinks E, Nagy Z, Bicknell R, Lee S. An evaluation of the tumour endothelial marker CLEC14A as a therapeutic target in solid tumours. J Pathol Clin Res. 2020;6:308-319 pubmed publisher
Kim T, Park C, Jang J, Kim M, Na H, Lee K, et al. Inhibition of VEGF-dependent angiogenesis and tumor angiogenesis by an optimized antibody targeting CLEC14a. Mol Oncol. 2018;12:356-372 pubmed publisher
Jang J, Kim M, Kim T, Lee W, Kim J, Heo K, et al. CLEC14a-HSP70-1A interaction regulates HSP70-1A-induced angiogenesis. Sci Rep. 2017;7:10666 pubmed publisher
Noy P, Swain R, Khan K, Lodhia P, Bicknell R. Sprouting angiogenesis is regulated by shedding of the C-type lectin family 14, member A (CLEC14A) ectodomain, catalyzed by rhomboid-like 2 protein (RHBDL2). FASEB J. 2016;30:2311-23 pubmed publisher

product information

brand :

R&D Systems

master code :

AF4968

SKU :

AF4968

product name :

Human CLEC14A Antibody

unit size :

100 ug (also 25 ug)

seo description :

The Human CLEC14A Antibody from R&D Systems is a sheep polyclonal antibody to CLEC14A. This antibody reacts with human,mouse. The Human CLEC14A Antibody has been validated for the following applications: Flow Cytometry,Western Blot,Neutralization,Immunohistochemistry,Immunohistochemistry-Paraffin,Immunocytochemistry,CyTOF-ready.

target :

CLEC14A

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Polyclonal

concentration :

LYOPH

conjugate :

Unconjugated

dilution :

Western Blot 0.1 ug/mL, Flow Cytometry 2.5 ug/10^6 cells, Immunohistochemistry 5-15 ug/mL, Immunocytochemistry 5-15 ug/mL, CyTOF-ready

host :

Sheep

immunogen :

Mouse myeloma cell line NS0-derived recombinant human CLEC14A, Glu22-Ala397, Accession # Q86T13

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Human,Mouse

specificity :

Detects human CLEC14A in direct ELISAs and Western blots. In direct ELISAs and Western blots, less than 1% cross-reactivity with recombinant human (rh) CLEC1, rhCLEC2, rhCLEC3B, and rhCLEC10A is observed.

gene symbol :

CLEC14A

top caption :

Detection of Clec-14A antibody in HUVEC Human Cells antibody by Flow Cytometry.

accessionNumbers :

Q86T13

applications :

CyTOF-ready,Flow Cytometry,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Neutralization,Immunocytochemistry

USD :

499 USD

alt names :

C14orf27, CEG1, chromosome 14 open reading frame 27, ClECT and EGF-like domain containing protein, C-type lectin domain family 14 member A, C-type lectin domain family 14, member A, EGF R5, EGFR5, EGFR-5, Epidermal growth factor receptor 5

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage