product summary
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company name :
R&D Systems
product type :
antibody
product name :
Mouse CD38 Antibody
catalog :
AF4947
quantity :
100 ug (also 25 ug)
price :
489 USD
clonality :
polyclonal
host :
domestic sheep
conjugate :
nonconjugated
reactivity :
mouse
application :
western blot, flow cytometry
more info or order :
citations: 6
Reference
Zeidler J, Chini C, Kanamori K, Kashyap S, Espindola Netto J, Thompson K, et al. Endogenous metabolism in endothelial and immune cells generates most of the tissue vitamin B3 (nicotinamide). iScience. 2022;25:105431 pubmed publisher
Nabar N, Heijjer C, Shi C, Hwang I, Ganesan S, Karlsson M, et al. LRRK2 is required for CD38-mediated NAADP-Ca2+ signaling and the downstream activation of TFEB (transcription factor EB) in immune cells. Autophagy. 2021;:1-19 pubmed publisher
Chini C, Peclat T, Warner G, Kashyap S, Espindola Netto J, de Oliveira G, et al. CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels. Nat Metab. 2020;2:1284-1304 pubmed publisher
Covarrubias A, Kale A, Perrone R, Lopez Dominguez J, Pisco A, Kasler H, et al. Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages. Nat Metab. 2020;2:1265-1283 pubmed publisher
Roboon J, Hattori T, Ishii H, Takarada Iemata M, Le T, Shiraishi Y, et al. Deletion of CD38 Suppresses Glial Activation and Neuroinflammation in a Mouse Model of Demyelination. Front Cell Neurosci. 2019;13:258 pubmed publisher
Chini C, Hogan K, Warner G, Tarragó M, Peclat T, Tchkonia T, et al. The NADase CD38 is induced by factors secreted from senescent cells providing a potential link between senescence and age-related cellular NAD+ decline. Biochem Biophys Res Commun. 2019;513:486-493 pubmed publisher
product information
master code :
AF4947
SKU :
AF4947
product name :
Mouse CD38 Antibody
unit size :
100 ug (also 25 ug)
description :
The Mouse CD38 Antibody from R&D Systems is a sheep polyclonal antibody to CD38. This antibody reacts with mouse,transgenic mouse. The Mouse CD38 Antibody has been validated for the following applications: Western Blot,Flow Cytometry,Simple Western,CyTOF-ready.
target :
CD38
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Polyclonal
concentration :
LYOPH
conjugate :
Unconjugated
host :
Sheep
immunogen :
Mouse myeloma cell line NS0-derived recombinant mouse CD38, Leu45-Thr304, Accession # EDL37596
isotype :
IgG
purity :
Antigen Affinity-purified
species :
Mouse
specificity :
Detects mouse CD38 in direct ELISAs and Western blots. In direct ELISAs and Western blots, approximately 20% cross-reactivity with recombinant human CD38 is observed.
gene symbol :
CD38
top caption :
Detection of Mouse CD38 antibody by Western Blot.
accessionNumbers :
EDL37596
applications :
Western Blot,Flow Cytometry,Simple Western,CyTOF-ready
USD :
489 USD
alt names :
2'-phospho-ADP-ribosyl cyclase, 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase (EC:2.4.99.20), 2'-phospho-cyclic-ADP-ribose transferase, ADPRC 1, ADPRC1, ADP-ribosyl Cyclase, ADP-ribosyl cyclase 1, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, cADPr hydrolase 1, CD_antigen: CD38, CD38, CD38 antigen, CD38 antigen (p45), CD38 molecule, cluster of differentiation 38, Cyclic ADP-ribose Hydrolase, Cyclic ADP-ribose hydrolase 1, EC 2.4.99.20, EC 3.2.2.6, EC:3.2.2.6, NAD(+) nucleosidase, T10
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.