Mouse CD38 Antibody | R&D Systems AF4947 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Mouse CD38 Antibody

catalog :

AF4947

quantity :

100 ug (also 25 ug)

price :

489 USD

clonality :

polyclonal

host :

domestic sheep

conjugate :

nonconjugated

reactivity :

mouse

application :

western blot, flow cytometry

more info or order :

R&D Systems product webpage

citations: 6

Reference
Zeidler J, Chini C, Kanamori K, Kashyap S, Espindola Netto J, Thompson K, et al. Endogenous metabolism in endothelial and immune cells generates most of the tissue vitamin B3 (nicotinamide). iScience. 2022;25:105431 pubmed publisher
Nabar N, Heijjer C, Shi C, Hwang I, Ganesan S, Karlsson M, et al. LRRK2 is required for CD38-mediated NAADP-Ca2+ signaling and the downstream activation of TFEB (transcription factor EB) in immune cells. Autophagy. 2021;:1-19 pubmed publisher
Chini C, Peclat T, Warner G, Kashyap S, Espindola Netto J, de Oliveira G, et al. CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels. Nat Metab. 2020;2:1284-1304 pubmed publisher
Covarrubias A, Kale A, Perrone R, Lopez Dominguez J, Pisco A, Kasler H, et al. Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages. Nat Metab. 2020;2:1265-1283 pubmed publisher
Roboon J, Hattori T, Ishii H, Takarada Iemata M, Le T, Shiraishi Y, et al. Deletion of CD38 Suppresses Glial Activation and Neuroinflammation in a Mouse Model of Demyelination. Front Cell Neurosci. 2019;13:258 pubmed publisher
Chini C, Hogan K, Warner G, Tarragó M, Peclat T, Tchkonia T, et al. The NADase CD38 is induced by factors secreted from senescent cells providing a potential link between senescence and age-related cellular NAD+ decline. Biochem Biophys Res Commun. 2019;513:486-493 pubmed publisher

product information

master code :

AF4947

SKU :

AF4947

product name :

Mouse CD38 Antibody

unit size :

100 ug (also 25 ug)

description :

The Mouse CD38 Antibody from R&D Systems is a sheep polyclonal antibody to CD38. This antibody reacts with mouse,transgenic mouse. The Mouse CD38 Antibody has been validated for the following applications: Western Blot,Flow Cytometry,Simple Western,CyTOF-ready.

target :

CD38

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Polyclonal

concentration :

LYOPH

conjugate :

Unconjugated

host :

Sheep

immunogen :

Mouse myeloma cell line NS0-derived recombinant mouse CD38, Leu45-Thr304, Accession # EDL37596

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Mouse

specificity :

Detects mouse CD38 in direct ELISAs and Western blots. In direct ELISAs and Western blots, approximately 20% cross-reactivity with recombinant human CD38 is observed.

gene symbol :

CD38

top caption :

Detection of Mouse CD38 antibody by Western Blot.

accessionNumbers :

EDL37596

applications :

Western Blot,Flow Cytometry,Simple Western,CyTOF-ready

USD :

489 USD

alt names :

2'-phospho-ADP-ribosyl cyclase, 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase (EC:2.4.99.20), 2'-phospho-cyclic-ADP-ribose transferase, ADPRC 1, ADPRC1, ADP-ribosyl Cyclase, ADP-ribosyl cyclase 1, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, cADPr hydrolase 1, CD_antigen: CD38, CD38, CD38 antigen, CD38 antigen (p45), CD38 molecule, cluster of differentiation 38, Cyclic ADP-ribose Hydrolase, Cyclic ADP-ribose hydrolase 1, EC 2.4.99.20, EC 3.2.2.6, EC:3.2.2.6, NAD(+) nucleosidase, T10

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage