product summary
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company name :
R&D Systems
product type :
antibody
product name :
Mouse CX3CL1/Fractalkine Chemokine Domain Antibody
catalog :
AF472
quantity :
100 ug (also 25 ug)
price :
479 USD
clonality :
polyclonal
host :
domestic goat
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, neutralization, flow cytometry, immunohistochemistry - paraffin section
more info or order :
R&D Systems product webpage
citations: 9
Reference
Long J, Liu H, Qiu Z, Xiao Z, Lu Z. Glabridin Therapy Reduces Chronic Allodynia, Spinal Microgliosis, and Dendritic Spine Generation by Inhibiting Fractalkine-CX3CR1 Signaling in a Mouse Model of Tibial Fractures. Brain Sci. 2023;13: pubmed publisher
Klapproth E, Witt A, Klose P, Wiedemann J, Vavilthota N, K xfc nzel S, et al. Targeting cardiomyocyte ADAM10 ectodomain shedding promotes survival early after myocardial infarction. Nat Commun. 2022;13:7648 pubmed publisher
Sun Y, Zhang X, Huang S, Pan H, Gai Y, Zhou Y, et al. Diet-Induced Obesity Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma via CX3CL1/CX3CR1 Axis. J Immunol Res. 2022;2022:5665964 pubmed publisher
Brett C, Carroll J, Gabriele M. Compromised fractalkine signaling delays microglial occupancy of emerging modules in the multisensory midbrain. Glia. 2022;70:697-711 pubmed publisher
Borghi S, Fattori V, Carvalho T, Tatakihara V, Zaninelli T, Pinho Ribeiro F, et al. Experimental Trypanosoma cruzi Infection Induces Pain in Mice Dependent on Early Spinal Cord Glial Cells and NFκB Activation and Cytokine Production. Front Immunol. 2020;11:539086 pubmed publisher
Borghi S, Fattori V, Pinho Ribeiro F, Domiciano T, Miranda Sapla M, Zaninelli T, et al. Contribution of spinal cord glial cells to L. amazonensis experimental infection-induced pain in BALB/c mice. J Neuroinflammation. 2019;16:113 pubmed publisher
Bolos M, Llorens Martín M, Perea J, Jurado Arjona J, Rabano A, Hernandez F, et al. Absence of CX3CR1 impairs the internalization of Tau by microglia. Mol Neurodegener. 2017;12:59 pubmed publisher
Simons B, Ferrini M, Carvalho S, Bassett D, Jaffar Z, Roberts K. PGI2 Controls Pulmonary NK Cells That Prevent Airway Sensitization to House Dust Mite Allergen. J Immunol. 2017;198:461-471 pubmed
Goto Y, Aoyama M, Sekiya T, Kakita H, Waguri Nagaya Y, Miyazawa K, et al. CXCR4+ CD45- Cells are Niche Forming for Osteoclastogenesis via the SDF-1, CXCL7, and CX3CL1 Signaling Pathways in Bone Marrow. Stem Cells. 2016;34:2733-2743 pubmed publisher
product information
brand :
R&D Systems
master code :
AF472
SKU :
AF472
product name :
Mouse CX3CL1/Fractalkine Chemokine Domain Antibody
unit size :
100 ug (also 25 ug)
seo description :
The Mouse CX3CL1/Fractalkine Chemokine Domain Antibody from R&D Systems is a goat polyclonal antibody to CX3CL1/Fractalkine. This antibody reacts with mouse. The Mouse CX3CL1/Fractalkine Chemokine Domain Antibody has been validated for the following applications: Bioassay,Flow Cytometry,Western Blot,Neutralization,Immunohistochemistry,Immunohistochemistry-Paraffin,In vivo assay,Immunocytochemistry.
target :
CX3CL1/Fractalkine
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Polyclonal
concentration :
LYOPH
conjugate :
Unconjugated
dilution :
Western Blot 0.1 ug/mL, Neutralization 0.3-1.5 ug/mL
host :
Goat
immunogen :
E. coli -derived recombinant mouse CX3CL1/Fractalkine, Leu22-Lys105, Accession # O35188
isotype :
IgG
purity :
Antigen Affinity-purified
species :
Mouse
specificity :
Detects mouse Fractalkine in direct ELISAs and Western blots. In direct ELISAs, less than 40% cross-reactivity with recombinant human Fractalkine and recombinant rat Fractalkine is observed.
gene symbol :
CX3CL1
endotoxin note :
<0.10 EU per 1 ╡g of the antibody by the LAL method.
top caption :
Chemotaxis Induced by CX3CL1/Fractalkine and Neutralization by Mouse CX3CL1/Fractalkine Antibody.
accessionNumbers :
O35188
applications :
Bioassay,Flow Cytometry,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,In vivo assay,Neutralization,Immunocytochemistry
USD :
479 USD
alt names :
ABCD-3, C3Xkine, chemokine (C-X3-C motif) ligand 1, CX3C membrane-anchored chemokine, CXC3, CXC3C, FKN, fractalkine, Neurotactin, neurotactin), NTNsmall inducible cytokine subfamily D (Cys-X3-Cys), member 1 (fractalkine, NTTSmall-inducible cytokine D1, SCYD1C-X3-C motif chemokine 1, small inducible cytokine subfamily D (Cys-X3-Cys), member-1
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.