Human/Mouse Sonic Hedgehog/Shh N-Terminus Antibody | R&D Systems AF464 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human/Mouse Sonic Hedgehog/Shh N-Terminus Antibody

catalog :

AF464

quantity :

100 ug (also 25 ug)

price :

509 USD

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat, chicken

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

R&D Systems product webpage

citations: 18

Reference
Ishan M, Wang Z, Zhao P, Yao Y, Stice S, Wells L, et al. Taste papilla cell differentiation requires tongue mesenchyme via ALK3-BMP signaling to regulate the production of secretory proteins. bioRxiv. 2023;: pubmed publisher
Kumari A, Li L, Ermilov A, Franks N, Dlugosz A, Allen B, et al. Unique lingual expression of the Hedgehog pathway antagonist Hedgehog-interacting protein in filiform papillae during homeostasis and ectopic expression in fungiform papillae during Hedgehog signaling inhibition. Dev Dyn. 2022;251:1175-1195 pubmed publisher
Chakrabarti J, Dua Awereh M, Schumacher M, Engevik A, Hawkins J, Helmrath M, et al. Sonic Hedgehog acts as a macrophage chemoattractant during regeneration of the gastric epithelium. NPJ Regen Med. 2022;7:3 pubmed publisher
Donnelly C, Kumari A, Li L, Vesela I, Bradley R, Mistretta C, et al. Probing the multimodal fungiform papilla: complex peripheral nerve endings of chorda tympani taste and mechanosensitive fibers before and after Hedgehog pathway inhibition. Cell Tissue Res. 2022;387:225-247 pubmed publisher
Ehring K, Manikowski D, Goretzko J, Froese J, Gude F, Jakobs P, et al. Conserved cholesterol-related activities of Dispatched 1 drive Sonic hedgehog shedding from the cell membrane. J Cell Sci. 2022;135: pubmed publisher
Kerekes K, Trexler M, Banyai L, Patthy L. Wnt Inhibitory Factor 1 Binds to and Inhibits the Activity of Sonic Hedgehog. Cells. 2021;10: pubmed publisher
Ancel J, Belgacemi R, Perotin J, Diabasana Z, Dury S, Dewolf M, et al. Sonic hedgehog signalling as a potential endobronchial biomarker in COPD. Respir Res. 2020;21:207 pubmed publisher
Belgacemi R, Luczka E, Ancel J, Diabasana Z, Perotin J, Germain A, et al. Airway epithelial cell differentiation relies on deficient Hedgehog signalling in COPD. EBioMedicine. 2020;51:102572 pubmed publisher
Ishan M, Chen G, Sun C, Chen S, Komatsu Y, Mishina Y, et al. Increased activity of mesenchymal ALK2-BMP signaling causes posteriorly truncated microglossia and disorganization of lingual tissues. Genesis. 2020;58:e23337 pubmed publisher
Binder M, Chmielarz P, McKinnon P, Biggs L, Thesleff I, Balic A. Functionally Distinctive Ptch Receptors Establish Multimodal Hedgehog Signaling in the Tooth Epithelial Stem Cell Niche. Stem Cells. 2019;37:1238-1248 pubmed publisher
Kramer N, Chen G, Ishan M, Cui X, Liu H. Early taste buds are from Shh+ epithelial cells of tongue primordium in distinction from mature taste bud cells which arise from surrounding tissue compartments. Biochem Biophys Res Commun. 2019;: pubmed publisher
Holokai L, Chakrabarti J, Broda T, Chang J, Hawkins J, Sundaram N, et al. Increased Programmed Death-Ligand 1 is an Early Epithelial Cell Response to Helicobacter pylori Infection. PLoS Pathog. 2019;15:e1007468 pubmed publisher
Kumari A, Yokota Y, Li L, Bradley R, Mistretta C. Species generalization and differences in Hedgehog pathway regulation of fungiform and circumvallate papilla taste function and somatosensation demonstrated with sonidegib. Sci Rep. 2018;8:16150 pubmed publisher
Sanz Navarro M, Seidel K, Sun Z, Bertonnier Brouty L, Amendt B, Klein O, et al. Plasticity within the niche ensures the maintenance of a Sox2+ stem cell population in the mouse incisor. Development. 2018;145: pubmed publisher
Zhang Z, Li Z, Deng W, He Q, Wang Q, Shi W, et al. Ectoderm mesenchymal stem cells promote differentiation and maturation of oligodendrocyte precursor cells. Biochem Biophys Res Commun. 2016;480:727-733 pubmed publisher
Ermilov A, Kumari A, Li L, Joiner A, Grachtchouk M, Allen B, et al. Maintenance of Taste Organs Is Strictly Dependent on Epithelial Hedgehog/GLI Signaling. PLoS Genet. 2016;12:e1006442 pubmed publisher
Singh V, Singh M, Gorantla S, Poluektova L, Maggirwar S. Smoothened Agonist Reduces Human Immunodeficiency Virus Type-1-Induced Blood-Brain Barrier Breakdown in Humanized Mice. Sci Rep. 2016;6:26876 pubmed publisher
Gaston Massuet C, McCabe M, Scagliotti V, Young R, Carreno G, Gregory L, et al. Transcription factor 7-like 1 is involved in hypothalamo-pituitary axis development in mice and humans. Proc Natl Acad Sci U S A. 2016;113:E548-57 pubmed publisher

product information

brand :

R&D Systems

master code :

AF464

SKU :

AF464

product name :

Human/Mouse Sonic Hedgehog/Shh N-Terminus Antibody

unit size :

100 ug (also 25 ug)

seo description :

The Human/Mouse Sonic Hedgehog/Shh N-Terminus Antibody from R&D Systems is a goat polyclonal antibody to Sonic Hedgehog/Shh. This antibody reacts with avian - chicken,human,mouse,rat. The Human/Mouse Sonic Hedgehog/Shh N-Terminus Antibody has been validated for the following applications: Immunohistochemistry,Western Blot,Bioassay,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry.

target :

Sonic Hedgehog/Shh

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Polyclonal

concentration :

LYOPH

conjugate :

Unconjugated

dilution :

Western Blot 1 ug/mL, Immunohistochemistry 5-15 ug/mL

host :

Goat

immunogen :

E. coli -derived recombinant mouse Sonic Hedgehog/Shh N-Terminus, Cys25-Gly198 (Lys122Arg), Accession # Q62226

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Avian - Chicken,Human,Mouse,Rat

specificity :

Detects human and mouse Sonic Hedgehog/Shh N-Terminus in direct ELISAs and Western blots. In direct ELISAs, less than 15% cross-reactivity with recombinant mouse (rm) Dhh N-Terminus and rmIhh N-Terminus is observed.

gene symbol :

SHH

top caption :

Detection of Human and Mouse Sonic Hedgehog/Shh antibody by Western Blot.

accessionNumbers :

Q62226

applications :

Bioassay,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry

USD :

509 USD

alt names :

HHG1, HHG-1, HLP3, HPE3, MCOPCB5, MCOPCB5sonic hedgehog (Drosophila) homolog, Shh, ShhNC, SMMCI, SMMCIsonic hedgehog homolog (Drosophila), sonic hedgehog, sonic hedgehog homolog, sonic hedgehog protein, TPT, TPTPS

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage