Mouse TRANCE/TNFSF11/RANK L Antibody | R&D Systems AF462 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Mouse TRANCE/TNFSF11/RANK L Antibody

catalog :

AF462

quantity :

100 ug (also 25 ug)

price :

519 USD

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, neutralization, immunohistochemistry - paraffin section, proximity ligation assay

more info or order :

R&D Systems product webpage

citations: 19

Reference
Woo H, Cho J, Lim Y. Propionibacterium freudenreichii MJ2-derived extracellular vesicles inhibit RANKL-induced osteoclastogenesis and improve collagen-induced rheumatoid arthritis. Sci Rep. 2024;14:24973 pubmed publisher
Northey J, Hayward M, Yui Y, Stashko C, Kai F, Mouw J, et al. Mechanosensitive hormone signaling promotes mammary progenitor expansion and breast cancer risk. Cell Stem Cell. 2024;31:106-126.e13 pubmed publisher
Yamamoto T, Abe M, Hongo H, Maruoka H, Yoshino H, Haraguchi Kitakamae M, et al. Differential osteoblastic activity in primary metaphyseal trabecular and secondary trabeculae of c-fos deficient mice. J Oral Biosci. 2023;65:265-272 pubmed publisher
Lai Z, Zhou W, Shi J, Meng Y, Wu J, Ye J, et al. RANKL up-regulated by progesterone aggravates lipopolysaccharide-induced acute lung injury during pregnancy. J Reprod Immunol. 2023;155:103788 pubmed publisher
Cappariello A, Muraca M, Teti A, Rucci N. Circulating Extracellular Vesicles Express Receptor Activator of Nuclear Factor κB Ligand and Other Molecules Informative of the Bone Metabolic Status of Mouse Models of Experimentally Induced Osteoporosis. Calcif Tissue Int. 2023;112:74-91 pubmed publisher
Sonoda S, Murata S, Yamaza H, Yuniartha R, Fujiyoshi J, Yoshimaru K, et al. Targeting hepatic oxidative stress rescues bone loss in liver fibrosis. Mol Metab. 2022;66:101599 pubmed publisher
Szwarc M, Hai L, Maurya V, Rajapakshe K, Perera D, Ittmann M, et al. Histopathologic and transcriptomic phenotypes of a conditional RANKL transgenic mouse thymus. Cytokine. 2022;160:156022 pubmed publisher
Gutgesell R, Jamshed L, Frank R, Hewitt L, Thomas P, Holloway A. Naphthenic acid fraction components from oil sands process-affected water from the Athabasca Oil Sands Region impair murine osteoblast differentiation and function. J Appl Toxicol. 2022;42:2005-2015 pubmed publisher
Lee S, Yap Y, Lim C, Woo A, Lin V. Activation function 1 of progesterone receptor is required for mammary development and regulation of RANKL during pregnancy. Sci Rep. 2022;12:12286 pubmed publisher
Inoue M, Nagai Yoshioka Y, Yamasaki R, Kawamoto T, Nishihara T, Ariyoshi W. Mechanisms involved in suppression of osteoclast supportive activity by transforming growth factor-β1 via the ubiquitin-proteasome system. PLoS ONE. 2022;17:e0262612 pubmed publisher
Du J, He Z, Cui J, Li H, Xu M, Zhang S, et al. Osteocyte Apoptosis Contributes to Cold Exposure-induced Bone Loss. Front Bioeng Biotechnol. 2021;9:733582 pubmed publisher
Li D, San M, Zhang J, Yang A, Xie W, Chen Y, et al. Oxytocin receptor induces mammary tumorigenesis through prolactin/p-STAT5 pathway. Cell Death Dis. 2021;12:588 pubmed publisher
Kim H, Xiong J, MacLeod R, Iyer S, Fujiwara Y, Cawley K, et al. Osteocyte RANKL is required for cortical bone loss with age and is induced by senescence. JCI Insight. 2020;5: pubmed publisher
Li M, Xu D. Antiresorptive activity of osteoprotegerin requires an intact heparan sulfate-binding site. Proc Natl Acad Sci U S A. 2020;117:17187-17194 pubmed publisher
Pascual R, Martín J, Salvador F, Reina O, Chanes V, Millanes Romero A, et al. The RNA binding protein CPEB2 regulates hormone sensing in mammary gland development and luminal breast cancer. Sci Adv. 2020;6:eaax3868 pubmed publisher
Hai L, Szwarc M, Lonard D, Rajapakshe K, Perera D, Coarfa C, et al. Short-term RANKL exposure initiates a neoplastic transcriptional program in the basal epithelium of the murine salivary gland. Cytokine. 2019;123:154745 pubmed publisher
Jhun J, Lee S, Kim S, Ryu J, Kwon J, Na H, et al. RIPK1 inhibition attenuates experimental autoimmune arthritis via suppression of osteoclastogenesis. J Transl Med. 2019;17:84 pubmed publisher
Xiong J, Cawley K, Piemontese M, Fujiwara Y, Zhao H, Goellner J, et al. Soluble RANKL contributes to osteoclast formation in adult mice but not ovariectomy-induced bone loss. Nat Commun. 2018;9:2909 pubmed publisher
Zhang X, Chiang H, Wang Y, Zhang C, Smith S, Zhao X, et al. Attenuation of RNA polymerase II pausing mitigates BRCA1-associated R-loop accumulation and tumorigenesis. Nat Commun. 2017;8:15908 pubmed publisher

product information

master code :

AF462

SKU :

AF462

product name :

Mouse TRANCE/TNFSF11/RANK L Antibody

unit size :

100 ug (also 25 ug)

description :

The Mouse TRANCE/TNFSF11/RANK L Antibody from R&D Systems is a goat polyclonal antibody to TRANCE/TNFSF11/RANK L. This antibody reacts with human,mouse,transgenic mouse. The Mouse TRANCE/TNFSF11/RANK L Antibody has been validated for the following applications: Western Blot,Immunohistochemistry,Immunocytochemistry,ELISA Development,Proximity Ligation Assay,Neutralization,Immunohistochemistry-Paraffin,ELISA Capture (Matched Antibody Pair).

target :

TRANCE/TNFSF11/RANK L

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Polyclonal

concentration :

LYOPH

conjugate :

Unconjugated

host :

Goat

immunogen :

Mouse myeloma cell line NS0-derived recombinant mouse TRANCE/TNFSF11/RANK L, Arg72-Asp316, Accession # O35235

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Human,Mouse,Transgenic Mouse

specificity :

Detects mouse TRANCE/TNFSF11/RANK L in ELISAs and Western blots.

gene symbol :

TNFSF11

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

top caption :

Osteoclast-like Cell Formation Induced by TRANCE/ TNFSF11/RANK L and Neutralization by Mouse TRANCE/TNFSF11/RANK L Antibody.

accessionNumbers :

O35235

applications :

Western Blot,Immunohistochemistry,Immunocytochemistry,ELISA Development,Proximity Ligation Assay,Neutralization,Immunohistochemistry-Paraffin,ELISA Capture (Matched Antibody Pair)

USD :

519 USD

alt names :

CD254, CD254 antigen, ODF, OPGL, OPGLOPTB2, Osteoclast differentiation factor, Osteoprotegerin ligand, RANK L, RANKL, RANKLreceptor activator of nuclear factor kappa B ligand, Receptor activator of nuclear factor kappa-B ligand, sOdf, TNF-related activation-induced cytokine, TNFSF11, TRANCEODFhRANKL2, tumor necrosis factor (ligand) superfamily, member 11, tumor necrosis factor ligand superfamily member 11

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage