Mouse Osteoprotegerin/TNFRSF11B Antibody | R&D Systems AF459 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Mouse Osteoprotegerin/TNFRSF11B Antibody

catalog :

AF459

quantity :

100 ug (also 25 ug)

price :

519 USD

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry, neutralization, flow cytometry

more info or order :

R&D Systems product webpage

citations: 9

Reference
Shahbandi A, Chiu F, Ungerleider N, Kvadas R, Mheidly Z, Sun M, et al. Breast cancer cells survive chemotherapy by activating targetable immune-modulatory programs characterized by PD-L1 or CD80. Nat Cancer. 2022;3:1513-1533 pubmed publisher
Tsuruda T, Yamashita A, Otsu M, Koide M, Nakamichi Y, Sekita Hatakeyama Y, et al. Angiotensin II Induces Aortic Rupture and Dissection in Osteoprotegerin-Deficient Mice. J Am Heart Assoc. 2022;11:e025336 pubmed publisher
Wang B, Guo H, Geng T, Sun K, Zhang L, LU Z, et al. The effect of strontium ranelate on titanium particle-induced periprosthetic osteolysis regulated by WNT/β-catenin signaling in vivo and in vitro. Biosci Rep. 2021;41: pubmed publisher
Li M, Xu D. Antiresorptive activity of osteoprotegerin requires an intact heparan sulfate-binding site. Proc Natl Acad Sci U S A. 2020;117:17187-17194 pubmed publisher
An J, Kerns K, Ouellette A, Robinson L, Morris H, Kaczorowski C, et al. Rapamycin rejuvenates oral health in aging mice. elife. 2020;9: pubmed publisher
Arnold N, Pickworth J, West L, Dawson S, Carvalho J, Casbolt H, et al. A therapeutic antibody targeting osteoprotegerin attenuates severe experimental pulmonary arterial hypertension. Nat Commun. 2019;10:5183 pubmed publisher
Gao X, Zheng J, Tu S, Cai B, Zeng R, Xiang L. Role of osteoprotegerin in the regulation of dental epithelial‑mesenchymal signaling during tooth development. Mol Med Rep. 2019;20:3035-3042 pubmed publisher
Xiao Y, Li M, Larocque R, Zhang F, Malhotra A, Chen J, et al. Dimerization interface of osteoprotegerin revealed by hydrogen-deuterium exchange mass spectrometry. J Biol Chem. 2018;293:17523-17535 pubmed publisher
Jadhav G, Teguh D, Kenny J, Tickner J, Xu J. Morc3 mutant mice exhibit reduced cortical area and thickness, accompanied by altered haematopoietic stem cells niche and bone cell differentiation. Sci Rep. 2016;6:25964 pubmed publisher

product information

master code :

AF459

SKU :

AF459

product name :

Mouse Osteoprotegerin/TNFRSF11B Antibody

unit size :

100 ug (also 25 ug)

description :

The Mouse Osteoprotegerin/TNFRSF11B Antibody from R&D Systems is a goat polyclonal antibody to Osteoprotegerin/TNFRSF11B. This antibody reacts with human,mouse. The Mouse Osteoprotegerin/TNFRSF11B Antibody has been validated for the following applications: Immunocytochemistry,Neutralization,Flow Cytometry,Western Blot,Immunohistochemistry.

target :

Osteoprotegerin/TNFRSF11B

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Polyclonal

concentration :

LYOPH

conjugate :

Unconjugated

host :

Goat

immunogen :

Mouse myeloma cell line NS0-derived recombinant mouse Osteoprotegerin/TNFRSF11B, Glu22-Leu401 with a Gln138Arg substitution, Accession # Q6PI12

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Human,Mouse

specificity :

Detects mouse Osteoprotegerin in direct ELISAs and Western blots. In direct ELISAs, approximately 40% cross-reactivity with recombinant human Osteoprotegerin is observed.

gene symbol :

TNFRSF11B

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

top caption :

Osteoprotegerin/TNFRSF11B Inhibition of TRAIL/TNFSF10-induced Cytotoxicity and Neutralization by Mouse Osteoprotegerin/TNFRSF11B Antibody.

accessionNumbers :

Q6PI12

applications :

Neutralization,Flow Cytometry,Western Blot,Immunohistochemistry

USD :

519 USD

alt names :

OCIF, OCIFMGC29565, OPG, OPGtumor necrosis factor receptor superfamily member 11B, Osteoclastogenesis inhibitory factor, Osteoprotegerin, TNFRSF11B, TR1, tumor necrosis factor receptor superfamily, member 11b

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage