product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human/Mouse GFR alpha-2/GDNF R alpha-2 Antibody
catalog :
AF429
quantity :
100 ug (also 25 ug)
price :
519 USD
clonality :
polyclonal
host :
domestic goat
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, neutralization, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
R&D Systems product webpage
citations: 15
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; 1:2000; fig s1
Renko J, Mahato A, Visnapuu T, Valkonen K, Karelson M, Voutilainen M, et al. Neuroprotective Potential of a Small Molecule RET Agonist in Cultured Dopamine Neurons and Hemiparkinsonian Rats. J Parkinsons Dis. 2021;11:1023-1046 pubmed publisher
Siatra P, Vatsellas G, Chatzianastasiou A, Balafas E, Manolakou T, Papapetropoulos A, et al. Return of the Tbx5; lineage-tracing reveals ventricular cardiomyocyte-like precursors in the injured adult mammalian heart. NPJ Regen Med. 2023;8:13 pubmed publisher
Blount Q, Hernandez Morato I, Moayedi Y, Pitman M. Expression of Glial Cell-Derived Neurotrophic Factor Receptors Within Nucleus Ambiguus During Rat Development. Laryngoscope. 2023;133:2240-2247 pubmed publisher
Li J, Sudiwala S, Berthoin L, Mohabbat S, Gaylord E, Sinada H, et al. Long-term functional regeneration of radiation-damaged salivary glands through delivery of a neurogenic hydrogel. Sci Adv. 2022;8:eadc8753 pubmed publisher
Gadomski S, Fielding C, Garc xed a Garc xed a A, Korn C, Kapeni C, Ashraf S, et al. A cholinergic neuroskeletal interface promotes bone formation during postnatal growth and exercise. Cell Stem Cell. 2022;29:528-544.e9 pubmed publisher
Fielding C, García García A, Korn C, Gadomski S, Fang Z, Reguera J, et al. Cholinergic signals preserve haematopoietic stem cell quiescence during regenerative haematopoiesis. Nat Commun. 2022;13:543 pubmed publisher
Defaye M, Abdullah N, Iftinca M, Hassan A, Agosti F, Zhang Z, et al. Gut-innervating TRPV1+ Neurons Drive Chronic Visceral Pain via Microglial P2Y12 Receptor. Cell Mol Gastroenterol Hepatol. 2022;13:977-999 pubmed publisher
Muzyka V, Badea T. Genetic interplay between transcription factor Pou4f1/Brn3a and neurotrophin receptor Ret in retinal ganglion cell type specification. Neural Dev. 2021;16:5 pubmed publisher
Boyd J, LoCoco P, Furr A, Bendele M, Tram M, Li Q, et al. Elevated dietary ω-6 polyunsaturated fatty acids induce reversible peripheral nerve dysfunction that exacerbates comorbid pain conditions. Nat Metab. 2021;3:762-773 pubmed publisher
Astori A, Tingvall Gustafsson J, Kuruvilla J, Coyaud E, Laurent E, Sunnerhagen M, et al. ARID1a Associates with Lymphoid-Restricted Transcription Factors and Has an Essential Role in T Cell Development. J Immunol. 2020;205:1419-1432 pubmed publisher
Cohen J, Edwards T, Liu A, Hirai T, Jones M, Wu J, et al. Cutaneous TRPV1+ Neurons Trigger Protective Innate Type 17 Anticipatory Immunity. Cell. 2019;178:919-932.e14 pubmed publisher
Ferreira J, Zheng C, Lombaert I, Goldsmith C, Cotrim A, Symonds J, et al. Neurturin Gene Therapy Protects Parasympathetic Function to Prevent Irradiation-Induced Murine Salivary Gland Hypofunction. Mol Ther Methods Clin Dev. 2018;9:172-180 pubmed publisher
Kim S, Moon G, Oh Y, Park J, Shin W, Jeong J, et al. Protection of nigral dopaminergic neurons by AAV1 transduction with Rheb(S16H) against neurotoxic inflammation in vivo. Exp Mol Med. 2018;50:e440 pubmed publisher
Emmerson E, May A, Berthoin L, Cruz Pacheco N, Nathan S, Mattingly A, et al. Salivary glands regenerate after radiation injury through SOX2-mediated secretory cell replacement. EMBO Mol Med. 2018;10: pubmed publisher
Trevaskis J, Sacramento C, Jouihan H, Ali S, Le Lay J, Oldham S, et al. Neurturin and a GLP-1 Analogue Act Synergistically to Alleviate Diabetes in Zucker Diabetic Fatty Rats. Diabetes. 2017;66:2007-2018 pubmed publisher
product information
brand :
R&D Systems
master code :
AF429
SKU :
AF429
product name :
Human/Mouse GFR alpha-2/GDNF R alpha-2 Antibody
unit size :
100 ug (also 25 ug)
seo description :
The Human/Mouse GFR alpha-2/GDNF R alpha-2 Antibody from R&D Systems is a goat polyclonal antibody to GFR alpha-2/GDNF R alpha-2. This antibody reacts with human,mouse,rat. The Human/Mouse GFR alpha-2/GDNF R alpha-2 Antibody has been validated for the following applications: Immunohistochemistry,IHC/IF,Flow Cytometry,Neutralization,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry,Western Blot,Blockade of Receptor-ligand Interaction.
target :
GFR alpha-2/GDNF R alpha-2
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Polyclonal
concentration :
LYOPH
conjugate :
Unconjugated
dilution :
Western Blot 0.1 ug/mL, Immunohistochemistry 5-15 ug/mL, Blockade of Receptor-ligand Interaction, Immunocytochemistry 5-15 ug/mL
host :
Goat
immunogen :
Mouse myeloma cell line NS0-derived recombinant mouse GFR alpha -2/GDNF R alpha -2, Ser22-Ser441, Accession # Q3UUD8
isotype :
IgG
purity :
Antigen Affinity-purified
species :
Human,Mouse,Rat
specificity :
Detects human and mouse GFR alpha -2/GDNF R alpha -2 in direct ELISAs and Western blots. In direct ELISAs and Western blots, less than 5% cross-reactivity with recombinant human GFR alpha -3 is observed.
gene symbol :
GFRA2
endotoxin note :
<0.10 EU per 1 ╡g of the antibody by the LAL method.
top caption :
GFRa-2/GDNF Ra-2 antibody in Mouse Splenocytes by Immunocytochemistry (ICC).
accessionNumbers :
Q3UUD8
applications :
Western Blot,Blockade of Receptor-ligand Interaction,IHC/IF,Flow Cytometry,Immunohistochemistry,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Neutralization,Immunocytochemistry
USD :
519 USD
alt names :
GDNF family receptor alpha 2, GDNF family receptor alpha-2, GDNF R alpha-2, GDNF receptor alpha-2, GDNF receptor beta, GDNFR-alpha-2, GDNFR-beta, GDNFRBRET ligand 2, GFR alpha2, GFRa-2, GFRA2, GFR-alpha 2, GFR-alpha-2, glial cell line derived neurotrophic factor receptor, beta, Neurturin receptor alpha, NRTNR-alpha, NTNRA, NTNR-alpha, PI-linked cell-surface accessory protein, RETL2TGF-beta-related neurotrophic factor receptor 2, TGF-beta related neurotrophic factor receptor 2, TRN receptor, GPI-anchored, TRNR2NRTNR-ALPHA
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.