Mouse SorCS2 Antibody | R&D Systems AF4237 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Mouse SorCS2 Antibody

catalog :

AF4237

quantity :

100 ug (also 25 ug)

price :

469 USD

clonality :

polyclonal

host :

domestic sheep

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - frozen section

more info or order :

R&D Systems product webpage

citations: 8

Reference
Ayon Olivas M, Wolf D, Andreska T, Granado N, L xfc ningschr xf6 r P, Ip C, et al. Dopaminergic Input Regulates the Sensitivity of Indirect Pathway Striatal Spiny Neurons to Brain-Derived Neurotrophic Factor. Biology (Basel). 2023;12: pubmed publisher
Skeldal S, Voss L, Lende J, Pedersen S, M xf8 lgaard S, Kaas M, et al. Alternative splicing regulates adaptor protein binding, trafficking, and activity of the Vps10p domain receptor SorCS2 in neuronal development. J Biol Chem. 2023;299:105102 pubmed publisher
Li Y, Guan X, He Y, Jia X, Pan L, Wang Y, et al. ProBDNF signaling is involved in periodontitis-induced depression-like behavior in mouse hippocampus. Int Immunopharmacol. 2023;116:109767 pubmed publisher
Yang J, Ma Q, Dincheva I, Giza J, Jing D, Marinic T, et al. SorCS2 is required for social memory and trafficking of the NMDA receptor. Mol Psychiatry. 2021;26:927-940 pubmed publisher
Malik A, Szydlowska K, Nizinska K, Asaro A, van Vliet E, Popp O, et al. SorCS2 Controls Functional Expression of Amino Acid Transporter EAAT3 and Protects Neurons from Oxidative Stress and Epilepsy-Induced Pathology. Cell Rep. 2019;26:2792-2804.e6 pubmed publisher
Uchiyama K, Tomita M, Yano M, Chida J, Hara H, Das N, et al. Prions amplify through degradation of the VPS10P sorting receptor sortilin. PLoS Pathog. 2017;13:e1006470 pubmed publisher
Ma Q, Yang J, Milner T, Vonsattel J, Palko M, Tessarollo L, et al. SorCS2-mediated NR2A trafficking regulates motor deficits in Huntington's disease. JCI Insight. 2017;2: pubmed publisher
Forge A, Taylor R, Dawson S, Lovett M, Jagger D. Disruption of SorCS2 reveals differences in the regulation of stereociliary bundle formation between hair cell types in the inner ear. PLoS Genet. 2017;13:e1006692 pubmed publisher

product information

brand :

R&D Systems

master code :

AF4237

SKU :

AF4237

product name :

Mouse SorCS2 Antibody

unit size :

100 ug (also 25 ug)

seo description :

The Mouse SorCS2 Antibody from R&D Systems is a sheep polyclonal antibody to SorCS2. This antibody reacts with mouse,n/a,transgenic mouse. The Mouse SorCS2 Antibody has been validated for the following applications: Immunoprecipitation,Western Blot,Immunohistochemistry,Immunohistochemistry-Frozen,Immunocytochemistry.

target :

SorCS2

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Polyclonal

concentration :

LYOPH

conjugate :

Unconjugated

dilution :

Western Blot 0.1 ug/mL, Immunohistochemistry 5-15 ug/mL

host :

Sheep

immunogen :

Mouse myeloma cell line NS0-derived recombinant mouse SorCS2, Ala118-Gly1078, Accession # Q9EPR5

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Mouse,N/A,Transgenic Mouse

specificity :

Detects mouse SorCS2 in direct ELISAs and Western blots. In direct ELISAs, approximately 10% cross-reactivity with recombinant human (rh) SorCS2 and less than 5% cross-reactivity with rhSorCS1 and recombinant mouse SorCS1 is observed.

gene symbol :

SORCS2

top caption :

SorCS2 antibody in Mouse Brain by Immunohistochemistry (IHC-Fr).

accessionNumbers :

Q9EPR5

applications :

Immunohistochemistry,Immunoprecipitation,Western Blot,Immunohistochemistry-Frozen,Immunocytochemistry

USD :

469 USD

alt names :

KIAA1329VPS10 domain receptor protein, sortilin-related VPS10 domain containing receptor 2, VPS10 domain-containing receptor SorCS2

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage