Human/Mouse COX-2 Antibody | R&D Systems AF4198 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human/Mouse COX-2 Antibody

catalog :

AF4198

quantity :

100 ug (also 25 ug)

price :

499 USD

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

R&D Systems product webpage

citations: 12

Reference
El Obeid A, Maashi Y, AlRoshody R, Alatar G, Aljudayi M, Al Eidi H, et al. Herbal melanin modulates PGE2 and IL-6 gastroprotective markers through COX-2 and TLR4 signaling in the gastric cancer cell line AGS. BMC Complement Med Ther. 2023;23:305 pubmed publisher
Tang C, Sun H, Kadoki M, Han W, Ye X, Makusheva Y, et al. Blocking Dectin-1 prevents colorectal tumorigenesis by suppressing prostaglandin E2 production in myeloid-derived suppressor cells and enhancing IL-22 binding protein expression. Nat Commun. 2023;14:1493 pubmed publisher
Liu J, Lane S, Lall R, Russo M, Farrell L, Debreli Coskun M, et al. Circulating hemopexin modulates anthracycline cardiac toxicity in patients and in mice. Sci Adv. 2022;8:eadc9245 pubmed publisher
x15a witalska M, Filip Psurska B, Milczarek M, Psurski M, Moszy x144 ska A, D x105 browska A, et al. Combined anticancer therapy with imidazoacridinone analogue C-1305 and paclitaxel in human lung and colon cancer xenografts-Modulation of tumour angiogenesis. J Cell Mol Med. 2022;26:3950-3964 pubmed publisher
Iwata Y, Miyao M, Hirotsu A, Tatsumi K, Matsuyama T, Uetsuki N, et al. The inhibitory effects of Orengedokuto on inducible PGE2 production in BV-2 microglial cells. Heliyon. 2021;7:e07759 pubmed publisher
Sheppe A, Santelices J, Czyz D, Edelmann M. Yersinia pseudotuberculosis YopJ Limits Macrophage Response by Downregulating COX-2-Mediated Biosynthesis of PGE2 in a MAPK/ERK-Dependent Manner. Microbiol Spectr. 2021;9:e0049621 pubmed publisher
Wu J, Zhang L, Shi J, He R, Yang W, Habtezion A, et al. Macrophage phenotypic switch orchestrates the inflammation and repair/regeneration following acute pancreatitis injury. EBioMedicine. 2020;58:102920 pubmed publisher
Carrillo Jimenez A, Deniz O, Niklison Chirou M, Ruiz R, Bezerra Salomão K, Stratoulias V, et al. TET2 Regulates the Neuroinflammatory Response in Microglia. Cell Rep. 2019;29:697-713.e8 pubmed publisher
Zhao P, Wang B, Zhang Z, Zhang W, Liu Y. Response gene to complement 32 expression in macrophages augments paracrine stimulation-mediated colon cancer progression. Cell Death Dis. 2019;10:776 pubmed publisher
Mo C, Wang Z, Bonewald L, Brotto M. Multi-Staged Regulation of Lipid Signaling Mediators during Myogenesis by COX-1/2 Pathways. Int J Mol Sci. 2019;20: pubmed publisher
Milian I, Silva R, Manzan Martins C, Barbosa B, Guirelli P, Ribeiro M, et al. Increased Toxoplasma gondii Intracellular Proliferation in Human Extravillous Trophoblast Cells (HTR8/SVneo Line) Is Sequentially Triggered by MIF, ERK1/2, and COX-2. Front Microbiol. 2019;10:852 pubmed publisher
Höing B, Kanaan O, Altenhoff P, Petri R, Thangavelu K, Schlüter A, et al. Stromal versus tumoral inflammation differentially contribute to metastasis and poor survival in laryngeal squamous cell carcinoma. Oncotarget. 2018;9:8415-8426 pubmed publisher

product information

brand :

R&D Systems

master code :

AF4198

SKU :

AF4198

product name :

Human/Mouse COX-2 Antibody

unit size :

100 ug (also 25 ug)

seo description :

The Human/Mouse COX-2 Antibody from R&D Systems is a goat polyclonal antibody to COX-2. This antibody reacts with human,mouse,xenograft. The Human/Mouse COX-2 Antibody has been validated for the following applications: Western Blot,Simple Western,Immunohistochemistry,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Intracellular Staining by Flow Cytometry,Immunocytochemistry,CyTOF-ready.

target :

COX-2

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Polyclonal

concentration :

LYOPH

conjugate :

Unconjugated

dilution :

Western Blot 1 ug/mL, Intracellular Staining by Flow Cytometry 2.5 ug/10^6 cells, Immunocytochemistry 5-15 ug/mL, CyTOF-ready

host :

Goat

immunogen :

E. coli -derived recombinant human COX-2, Ala18-Leu604, Accession # P35354

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Human,Mouse,Xenograft

specificity :

Detects human and mouse COX-2 in Western blots. In Western blots, less than 1% cross-reactivity with recombinant human COX-1 is observed.

gene symbol :

PTGS2

top caption :

Detection of Human and Mouse COX-2 antibody by Western Blot.

accessionNumbers :

P35354

applications :

Intracellular Staining by Flow Cytometry,Immunocytochemistry,CyTOF-ready,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Simple Western

USD :

499 USD

alt names :

COX2, COX-2, COX2cyclooxygenase 2b, cyclooxygenase-2, EC 1.14.99, EC 1.14.99.1, GRIPGHS, hCox-2, PGG/HS, PGH synthase 2, PGHS-2, PHS II, PHS-2, PHS-II, prostaglandin G/H synthase 2, prostaglandin G/H synthase and cyclooxygenase, Prostaglandin H2 synthase 2, Prostaglandin-endoperoxide synthase 2, prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase andcyclooxygenase), PTGS2

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage