Mouse/Rat Proprotein Convertase 9/PCSK9 Antibody | R&D Systems AF3985 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Mouse/Rat Proprotein Convertase 9/PCSK9 Antibody

catalog :

AF3985

quantity :

100 ug (also 25 ug)

price :

499 USD

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry

more info or order :

R&D Systems product webpage

citations: 16

Reference
Wang Y, Tinsley B, Spolitu S, Zadroga J, Agarwal H, Sarecha A, et al. Geranylgeranyl Isoprenoids and Hepatic Rap1a Regulate Basal and Statin-Induced Expression of PCSK9. bioRxiv. 2023;: pubmed publisher
Pakalni x161 kyt x117 D, Sch xf6 nberger T, Strobel B, Stierstorfer B, Lamla T, Schuler M, et al. Rosa26-LSL-dCas9-VPR: a versatile mouse model for tissue specific and simultaneous activation of multiple genes for drug discovery. Sci Rep. 2022;12:19268 pubmed publisher
Stomberski C, Venetos N, Zhou H, Qian Z, Collison B, Field S, et al. A multienzyme S-nitrosylation cascade regulates cholesterol homeostasis. Cell Rep. 2022;41:111538 pubmed publisher
Hjorth M, Doncheva A, Norheim F, Ulven S, Holven K, S xe6 ther T, et al. Consumption of salmon fishmeal increases hepatic cholesterol content in obese C57BL/6 J mice. Eur J Nutr. 2022;61:4027-4043 pubmed publisher
Petersen Uribe x, Kremser M, Rohlfing A, Castor T, Kolb K, Dicenta V, et al. Platelet-Derived PCSK9 Is Associated with LDL Metabolism and Modulates Atherothrombotic Mechanisms in Coronary Artery Disease. Int J Mol Sci. 2021;22: pubmed publisher
Haberl E, Pohl R, Rein Fischboeck L, Höring M, Krautbauer S, Liebisch G, et al. Accumulation of cholesterol, triglycerides and ceramides in hepatocellular carcinomas of diethylnitrosamine injected mice. Lipids Health Dis. 2021;20:135 pubmed publisher
Rothgangl T, Dennis M, Lin P, Oka R, Witzigmann D, Villiger L, et al. In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels. Nat Biotechnol. 2021;39:949-957 pubmed publisher
Liu X, Bao X, Hu M, Chang H, Jiao M, Cheng J, et al. Inhibition of PCSK9 potentiates immune checkpoint therapy for cancer. Nature. 2020;588:693-698 pubmed publisher
Wolf A, Kutsche H, Schreckenberg R, Weber M, Li L, Rohrbach S, et al. Autocrine effects of PCSK9 on cardiomyocytes. Basic Res Cardiol. 2020;115:65 pubmed publisher
Chella Krishnan K, Floyd R, Sabir S, Jayasekera D, Leon Mimila P, Jones A, et al. Liver Pyruvate Kinase Promotes NAFLD/NASH in Both Mice and Humans in a Sex-Specific Manner. Cell Mol Gastroenterol Hepatol. 2021;11:389-406 pubmed publisher
Spolitu S, Okamoto H, Dai W, Zadroga J, Wittchen E, Gromada J, et al. Hepatic Glucagon Signaling Regulates PCSK9 and Low-Density Lipoprotein Cholesterol. Circ Res. 2019;124:38-51 pubmed publisher
Edraki A, Mir A, Ibraheim R, Gainetdinov I, Yoon Y, Song C, et al. A Compact, High-Accuracy Cas9 with a Dinucleotide PAM for In Vivo Genome Editing. Mol Cell. 2019;73:714-726.e4 pubmed publisher
Dettlaff Pokora A, Sucajtys Szulc E, Sledzinski T. Up-regulation of PCSK9 gene expression and diminished level of LDL-receptor in rat liver as a potential cause of post-lipectomy hypercholesterolemia. Mol Cell Biochem. 2019;455:207-217 pubmed publisher
Ibraheim R, Song C, Mir A, Amrani N, Xue W, Sontheimer E. All-in-one adeno-associated virus delivery and genome editing by Neisseria meningitidis Cas9 in vivo. Genome Biol. 2018;19:137 pubmed publisher
Kim K, Goldberg I, Graham M, Sundaram M, Bertaggia E, Lee S, et al. γ-Secretase Inhibition Lowers Plasma Triglyceride-Rich Lipoproteins by Stabilizing the LDL Receptor. Cell Metab. 2018;27:816-827.e4 pubmed publisher
Gustafsen C, Olsen D, Vilstrup J, Lund S, Reinhardt A, Wellner N, et al. Heparan sulfate proteoglycans present PCSK9 to the LDL receptor. Nat Commun. 2017;8:503 pubmed publisher

product information

brand :

R&D Systems

master code :

AF3985

SKU :

AF3985

product name :

Mouse/Rat Proprotein Convertase 9/PCSK9 Antibody

unit size :

100 ug (also 25 ug)

seo description :

The Mouse/Rat Proprotein Convertase 9/PCSK9 Antibody from R&D Systems is a goat polyclonal antibody to Proprotein Convertase 9/PCSK9. This antibody reacts with hamster,human,mouse,rat,transgenic mouse. The Mouse/Rat Proprotein Convertase 9/PCSK9 Antibody has been validated for the following applications: Western Blot,Simple Western,In vivo assay,Immunocytochemistry.

target :

Proprotein Convertase 9/PCSK9

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Polyclonal

concentration :

LYOPH

conjugate :

Unconjugated

dilution :

Western Blot 1 ug/mL

host :

Goat

immunogen :

Mouse myeloma cell line NS0-derived recombinant mouse Proprotein Convertase 9, Ser156-Gln694, Accession # Q80W65

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Hamster,Human,Mouse,Rat,Transgenic Mouse

specificity :

Detects mouse and rat Proprotein Convertase 9/PCSK9 in direct ELISAs and Western blots.

gene symbol :

PCSK9

top caption :

Detection of Mouse and Rat Proprotein Convertase 9/PCSK9 antibody by Western Blot.

accessionNumbers :

Q80W65

applications :

Western Blot,In vivo assay,Simple Western,Immunocytochemistry

USD :

499 USD

alt names :

EC 3.4.21, EC 3.4.21.111, FH3, FH3neural apoptosis regulated convertase 1, FHCL3, HCHOLA3, hypercholesterolemia, autosomal dominant 3, LDLCQ1, NARC1, NARC-1, NARC-1convertase subtilisin/kexin type 9 preproprotein, NARC1EC 3.4.21.-, Neural apoptosis-regulated convertase 1, PC9, PCSK9, Proprotein convertase 9, proprotein convertase subtilisin/kexin type 9, Subtilisin/kexin-like protease PC9

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage