Mouse/Rat PTP1B Antibody | R&D Systems AF3954 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Mouse/Rat PTP1B Antibody

catalog :

AF3954

quantity :

100 ug (also 25 ug)

price :

499 USD

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunohistochemistry - frozen section

more info or order :

R&D Systems product webpage

citations: 10

Reference
Liu Y, Zhang J, Du Z, Huang J, Cheng Y, Yi W, et al. Comprehensive analysis of PTPN family expression and prognosis in acute myeloid leukemia. Front Genet. 2022;13:1087938 pubmed publisher
Ito Y, Sun R, Yagimuma H, Taki K, Mizoguchi A, Kobayashi T, et al. Protein Tyrosine Phosphatase 1B Deficiency Improves Glucose Homeostasis in Type 1 Diabetes Treated With Leptin. Diabetes. 2022;71:1902-1914 pubmed publisher
Wiede F, Lu K, Du X, Zeissig M, Xu R, Goh P, et al. PTP1B Is an Intracellular Checkpoint that Limits T-cell and CAR T-cell Antitumor Immunity. Cancer Discov. 2022;12:752-773 pubmed publisher
Ferrer B, Suresh H, Santamaria A, Rocha J, Bowman A, Aschner M. The antioxidant role of STAT3 in methylmercury-induced toxicity in mouse hypothalamic neuronal GT1-7 cell line. Free Radic Biol Med. 2021;171:245-259 pubmed publisher
Ferrer B, Prince L, Tinkov A, Santamaria A, Farina M, Rocha J, et al. Chronic exposure to methylmercury enhances the anorexigenic effects of leptin in C57BL/6J male mice. Food Chem Toxicol. 2021;147:111924 pubmed publisher
Hsu M, Koike S, Mello A, Nagy L, Haj F. Hepatic protein-tyrosine phosphatase 1B disruption and pharmacological inhibition attenuate ethanol-induced oxidative stress and ameliorate alcoholic liver disease in mice. Redox Biol. 2020;36:101658 pubmed publisher
Dodd G, Xirouchaki C, Eramo M, Mitchell C, Andrews Z, Henry B, et al. Intranasal Targeting of Hypothalamic PTP1B and TCPTP Reinstates Leptin and Insulin Sensitivity and Promotes Weight Loss in Obesity. Cell Rep. 2019;28:2905-2922.e5 pubmed publisher
Xu Y, Taylor P, Andrade J, Ueberheide B, Shuch B, Glazer P, et al. Pathologic Oxidation of PTPN12 Underlies ABL1 Phosphorylation in Hereditary Leiomyomatosis and Renal Cell Carcinoma. Cancer Res. 2018;78:6539-6548 pubmed publisher
Tsutsumi R, Harizanova J, Stockert R, Schröder K, Bastiaens P, Neel B. Assay to visualize specific protein oxidation reveals spatio-temporal regulation of SHP2. Nat Commun. 2017;8:466 pubmed publisher
Tsunekawa T, Banno R, Mizoguchi A, Sugiyama M, Tominaga T, Onoue T, et al. Deficiency of PTP1B Attenuates Hypothalamic Inflammation via Activation of the JAK2-STAT3 Pathway in Microglia. EBioMedicine. 2017;16:172-183 pubmed publisher

product information

master code :

AF3954

SKU :

AF3954

product name :

Mouse/Rat PTP1B Antibody

unit size :

100 ug (also 25 ug)

description :

The Mouse/Rat PTP1B Antibody from R&D Systems is a goat polyclonal antibody to PTP1B/PTPN1. This antibody reacts with human,mouse,rat. The Mouse/Rat PTP1B Antibody has been validated for the following applications: Western Blot,Immunohistochemistry,Immunohistochemistry-Frozen,Simple Western.

target :

PTP1B

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Polyclonal

concentration :

LYOPH

conjugate :

Unconjugated

host :

Goat

immunogen :

E. coli -derived recombinant mouse PTP1B, Met1-Phe431, Accession # P35821

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Human,Mouse,Rat

specificity :

Detects mouse and rat PTP1B in Western blots. In Western blots, less than 1% cross-reactivity with recombinant human PTP1B is observed.

gene symbol :

PTPN1

top caption :

Detection of Mouse/Rat PTP1B antibody by Western Blot.

accessionNumbers :

P35821

applications :

Western Blot,Immunohistochemistry,Immunohistochemistry-Frozen,Simple Western

USD :

499 USD

alt names :

EC 3.1.3.48, protein tyrosine phosphatase 1B, protein tyrosine phosphatase, non-receptor type 1, Protein-tyrosine phosphatase 1B, PTP-1B, PTP1Bprotein tyrosine phosphatase, placental, PTPN1, tyrosine-protein phosphatase non-receptor type 1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage