product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human Matriptase/ST14 Catalytic Domain Antibody
catalog :
AF3946
quantity :
100 ug (also 25 ug)
price :
519 USD
clonality :
polyclonal
host :
domestic sheep
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section
more info or order :
R&D Systems product webpage
citations: 11
Reference
Rickman O, Guignard E, Chabanon T, Bertoldi G, Auberson M, Hummler E. Tmprss2 maintains epithelial barrier integrity and transepithelial sodium transport. Life Sci Alliance. 2024;7: pubmed publisher
Ehret E, Stroh S, Auberson M, Ino F, J xe4 ger Y, Maillard M, et al. Kidney-Specific Membrane-Bound Serine Proteases CAP1/Prss8 and CAP3/St14 Affect ENaC Subunit Abundances but Not Its Activity. Cells. 2023;12: pubmed publisher
Chen L, Chai K. Exosome-Mediated Activation of the Prostasin-Matriptase Serine Protease Cascade in B Lymphoma Cells. Cancers (Basel). 2023;15: pubmed publisher
da Silva E, Fraga Silva T, Yuan Y, Alves M, Publio G, Da Fonseca C, et al. Kallikrein 5 Inhibition by the Lympho-Epithelial Kazal-Type Related Inhibitor Hinders Matriptase-Dependent Carcinogenesis. Cancers (Basel). 2021;13: pubmed publisher
Essigke D, Ilyaskin A, Wörn M, Bohnert B, Xiao M, Daniel C, et al. Zymogen-locked mutant prostasin (Prss8) leads to incomplete proteolytic activation of the epithelial sodium channel (ENaC) and severely compromises triamterene tolerance in mice. Acta Physiol (Oxf). 2021;232:e13640 pubmed publisher
Wu C, Lu M, Feng X, Nakato G, Udey M. Matriptase Cleaves EpCAM and TROP2 in Keratinocytes, Destabilizing Both Proteins and Associated Claudins. Cells. 2020;9: pubmed publisher
Drees L, Königsmann T, Jaspers M, Pflanz R, Riedel D, Schuh R. Conserved function of the matriptase-prostasin proteolytic cascade during epithelial morphogenesis. PLoS Genet. 2019;15:e1007882 pubmed publisher
Friis S, Tadeo D, Le Gall S, Jürgensen H, Sales K, Camerer E, et al. Matriptase zymogen supports epithelial development, homeostasis and regeneration. BMC Biol. 2017;15:46 pubmed publisher
Buzza M, Johnson T, Conway G, Martin E, Mukhopadhyay S, Shea Donohue T, et al. Inflammatory cytokines down-regulate the barrier-protective prostasin-matriptase proteolytic cascade early in experimental colitis. J Biol Chem. 2017;292:10801-10812 pubmed publisher
Wu C, Feng X, Lu M, Morimura S, Udey M. Matriptase-mediated cleavage of EpCAM destabilizes claudins and dysregulates intestinal epithelial homeostasis. J Clin Invest. 2017;127:623-634 pubmed publisher
Friis S, Madsen D, Bugge T. Distinct Developmental Functions of Prostasin (CAP1/PRSS8) Zymogen and Activated Prostasin. J Biol Chem. 2016;291:2577-82 pubmed publisher
product information
brand :
R&D Systems
master code :
AF3946
SKU :
AF3946
product name :
Human Matriptase/ST14 Catalytic Domain Antibody
unit size :
100 ug (also 25 ug)
seo description :
The Human Matriptase/ST14 Catalytic Domain Antibody from R&D Systems is a sheep polyclonal antibody to Matriptase/ST14. This antibody reacts with human,insect - drosophila,mouse. The Human Matriptase/ST14 Catalytic Domain Antibody has been validated for the following applications: Western Blot,Simple Western,Immunohistochemistry,Immunohistochemistry-Paraffin,Immunocytochemistry,Intracellular Staining by Flow Cytometry,CyTOF-ready.
target :
Matriptase/ST14
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Polyclonal
concentration :
LYOPH
conjugate :
Unconjugated
dilution :
Western Blot 0.1 ug/mL, Intracellular Staining by Flow Cytometry 2.5 ug/10^6 cells, CyTOF-ready
host :
Sheep
immunogen :
E. coli -derived recombinant human Matriptase/ST14 Catalytic Domain, Val615-Val855, Accession # Q9Y5Y6
isotype :
IgG
purity :
Antigen Affinity-purified
species :
Human,Insect - Drosophila,Mouse
specificity :
Detects human Matriptase/ST14 Catalytic Domain in direct ELISAs and Western blots.
gene symbol :
ST14
top caption :
Detection of Matriptase/ST14 Catalytic Domain antibody in PC-3 Human Cell Line antibody by Flow Cytometry.
accessionNumbers :
Q9Y5Y6
applications :
Intracellular Staining by Flow Cytometry,CyTOF-ready,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Simple Western,Immunocytochemistry
USD :
519 USD
alt names :
EC 3.4.21, Epithin, HAI, Matriptase, Membrane-type serine protease 1, MTSP1, MT-SP1EC 3.4.21.109, prostamin, PRSS14, Serine protease 14, Serine protease TADG-15, SNC19, SNC19MTSP1, ST14, suppression of tumorigenicity 14 (colon carcinoma), suppression of tumorigenicity 14 (colon carcinoma, matriptase, epithin), suppressor of tumorigenicity 14 protein, TADG15, TADG-15, TMPRSS14, tumor associated differentially expressed gene 15 protein, Tumor-associated differentially-expressed gene 15 protein
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.