Human Proprotein Convertase 9/PCSK9 Antibody | R&D Systems AF3888 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human Proprotein Convertase 9/PCSK9 Antibody

catalog :

AF3888

quantity :

100 ug (also 25 ug)

price :

499 USD

clonality :

polyclonal

host :

domestic sheep

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunocytochemistry, neutralization, immunoprecipitation

more info or order :

R&D Systems product webpage

citations: 6

Reference
Alannan M, Tr xe9 z xe9 guet V, Amo xea do N, Rossignol R, Mahfouf W, Rezvani H, et al. Rewiring Lipid Metabolism by Targeting PCSK9 and HMGCR to Treat Liver Cancer. Cancers (Basel). 2022;15: pubmed publisher
Alannan M, Fatrouni H, Tr xe9 z xe9 guet V, Dittrich Domergue F, Moreau P, Siegfried G, et al. Targeting PCSK9 in Liver Cancer Cells Triggers Metabolic Exhaustion and Cell Death by Ferroptosis. Cells. 2022;12: pubmed publisher
Saitoski K, Ryaboshapkina M, Hamza G, Jarnuczak A, Berthault C, Carlotti F, et al. Proprotein convertase PCSK9 affects expression of key surface proteins in human pancreatic beta cells via intracellular and extracellular regulatory circuits. J Biol Chem. 2022;298:102096 pubmed publisher
Moreau F, Th xe9 drez A, Gar xe7 on D, Ayer A, Sotin T, Dijk W, et al. PCSK9 is not secreted from mature differentiated intestinal cells. J Lipid Res. 2021;62:100096 pubmed publisher
Li X, Guo J, Liang N, Jiang X, Song Y, Ou S, et al. 6-Gingerol Regulates Hepatic Cholesterol Metabolism by Up-regulation of LDLR and Cholesterol Efflux-Related Genes in HepG2 Cells. Front Pharmacol. 2018;9:159 pubmed publisher
Gustafsen C, Olsen D, Vilstrup J, Lund S, Reinhardt A, Wellner N, et al. Heparan sulfate proteoglycans present PCSK9 to the LDL receptor. Nat Commun. 2017;8:503 pubmed publisher

product information

brand :

R&D Systems

master code :

AF3888

SKU :

AF3888

product name :

Human Proprotein Convertase 9/PCSK9 Antibody

unit size :

100 ug (also 25 ug)

seo description :

The Human Proprotein Convertase 9/PCSK9 Antibody from R&D Systems is a sheep polyclonal antibody to Proprotein Convertase 9/PCSK9. This antibody reacts with human. The Human Proprotein Convertase 9/PCSK9 Antibody has been validated for the following applications: Western Blot,Neutralization,Immunocytochemistry,ELISA,Immunoprecipitation.

target :

Proprotein Convertase 9/PCSK9

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Polyclonal

concentration :

LYOPH

conjugate :

Unconjugated

dilution :

Western Blot 1 ug/mL, ELISA, Immunoprecipitation 25 ug/mL

host :

Sheep

immunogen :

Mouse myeloma cell line NS0-derived recombinant human PCSK9 isoform 1, Gln31-Gln692, Accession # Q8NBP7

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Human

specificity :

Detects human PCSK9 in direct ELISAs and Western blots. In direct ELISAs, approximately 50% cross-reactivity with recombinant mouse PCSK9 is observed.

gene symbol :

PCSK9

top caption :

Detection of Human Proprotein Convertase 9/PCSK9 antibody by Western Blot.

accessionNumbers :

Q8NBP7

applications :

ELISA,Immunoprecipitation,Western Blot,Neutralization,Immunocytochemistry

USD :

499 USD

alt names :

EC 3.4.21, EC 3.4.21.111, FH3, FH3neural apoptosis regulated convertase 1, FHCL3, HCHOLA3, hypercholesterolemia, autosomal dominant 3, LDLCQ1, NARC1, NARC-1, NARC-1convertase subtilisin/kexin type 9 preproprotein, NARC1EC 3.4.21.-, Neural apoptosis-regulated convertase 1, PC9, PCSK9, Proprotein convertase 9, proprotein convertase subtilisin/kexin type 9, Subtilisin/kexin-like protease PC9

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage