Human Neuropilin-1 Antibody | R&D Systems AF3870 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human Neuropilin-1 Antibody

catalog :

AF3870

quantity :

100 ug (also 25 ug)

price :

489 USD

clonality :

polyclonal

host :

domestic sheep

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, neutralization, flow cytometry

more info or order :

R&D Systems product webpage

citations: 14

Reference
Gc S, Tuy K, Rickenbacker L, Jones R, Chakraborty A, Miller C, et al. α2,6 Sialylation mediated by ST6GAL1 promotes glioblastoma growth. JCI Insight. 2022;7: pubmed publisher
Gioelli N, Neilson L, Wei N, Villari G, Chen W, Kuhle B, et al. Neuropilin 1 and its inhibitory ligand mini-tryptophanyl-tRNA synthetase inversely regulate VE-cadherin turnover and vascular permeability. Nat Commun. 2022;13:4188 pubmed publisher
Argueta L, Lacko L, Bram Y, Tada T, Carrau L, Rendeiro A, et al. Inflammatory responses in the placenta upon SARS-CoV-2 infection late in pregnancy. iScience. 2022;25:104223 pubmed publisher
Severa M, Diotti R, Etna M, Rizzo F, Fiore S, Ricci D, et al. Differential plasmacytoid dendritic cell phenotype and type I Interferon response in asymptomatic and severe COVID-19 infection. PLoS Pathog. 2021;17:e1009878 pubmed publisher
Argueta L, Lacko L, Bram Y, Tada T, Carrau L, Zhang T, et al. SARS-CoV-2 Infects Syncytiotrophoblast and Activates Inflammatory Responses in the Placenta. bioRxiv. 2021;: pubmed publisher
Tang X, Uhl S, Zhang T, Xue D, Li B, Vandana J, et al. SARS-CoV-2 infection induces beta cell transdifferentiation. Cell Metab. 2021;33:1577-1591.e7 pubmed publisher
Dumond A, Brachet E, Durivault J, Vial V, Puszko A, Lepelletier Y, et al. Neuropilin 1 and Neuropilin 2 gene invalidation or pharmacological inhibition reveals their relevance for the treatment of metastatic renal cell carcinoma. J Exp Clin Cancer Res. 2021;40:33 pubmed publisher
Wei S, Huang Y, Hsieh M, Lin Y, Shyu W, Chen H, et al. Atypical chemokine receptor ACKR3/CXCR7 controls postnatal vasculogenesis and arterial specification by mesenchymal stem cells via Notch signaling. Cell Death Dis. 2020;11:307 pubmed publisher
Plant T, Eamsamarng S, Sánchez García M, Reyes L, Renshaw S, Coelho P, et al. Semaphorin 3F signaling actively retains neutrophils at sites of inflammation. J Clin Invest. 2020;130:3221-3237 pubmed publisher
Ding N, Zou Z, Sha H, Su S, Qian H, Meng F, et al. iRGD synergizes with PD-1 knockout immunotherapy by enhancing lymphocyte infiltration in gastric cancer. Nat Commun. 2019;10:1336 pubmed publisher
Giandomenico S, Mierau S, Gibbons G, Wenger L, Masullo L, Sit T, et al. Cerebral organoids at the air-liquid interface generate diverse nerve tracts with functional output. Nat Neurosci. 2019;22:669-679 pubmed publisher
van der Klaauw A, Croizier S, Mendes de Oliveira E, Stadler L, Park S, Kong Y, et al. Human Semaphorin 3 Variants Link Melanocortin Circuit Development and Energy Balance. Cell. 2019;176:729-742.e18 pubmed publisher
Mehta V, Fields L, Evans I, Yamaji M, Pellet Many C, Jones T, et al. VEGF (Vascular Endothelial Growth Factor) Induces NRP1 (Neuropilin-1) Cleavage via ADAMs (a Disintegrin and Metalloproteinase) 9 and 10 to Generate Novel Carboxy-Terminal NRP1 Fragments That Regulate Angiogenic Signaling. Arterioscler Thromb Vasc Biol. 2018;: pubmed publisher
Kerros C, Tripathi S, Zha D, Mehrens J, Sergeeva A, Philips A, et al. Neuropilin-1 mediates neutrophil elastase uptake and cross-presentation in breast cancer cells. J Biol Chem. 2017;292:10295-10305 pubmed publisher

product information

master code :

AF3870

SKU :

AF3870

product name :

Human Neuropilin-1 Antibody

unit size :

100 ug (also 25 ug)

description :

The Human Neuropilin-1 Antibody from R&D Systems is a sheep polyclonal antibody to Neuropilin-1. This antibody reacts with human,mouse. The Human Neuropilin-1 Antibody has been validated for the following applications: Immunocytochemistry,Flow Cytometry,Western Blot,Neutralization,Functional Assay,ELISA Capture,Immunohistochemistry,Blockade of Receptor-ligand Interaction,CyTOF-ready.

target :

Neuropilin-1

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Polyclonal

conjugate :

Unconjugated

host :

Sheep

immunogen :

Mouse myeloma cell line NS0-derived recombinant human Neuropilin-1, Phe22-Lys644, Accession # NP_001019799

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Human,Mouse

specificity :

Detects human Neuropilin-1 in direct ELISAs and Western blots. In direct ELISAs, less than 50% cross-reactivity with recombinant rat Neuropilin-1 and recombinant mouse Neuropilin-1 is observed, and less than 1% cross-reactivity with recombinant human Neuropilin-2 is observed.

gene symbol :

NRP1

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

Antibody validation :

Knockout/Knockdown

top caption :

Detection of Human Neuropilin-1 antibody by Western Blot.

accessionNumbers :

NP_001019799

applications :

Flow Cytometry,Western Blot,Neutralization,Functional Assay,ELISA Capture,Immunohistochemistry,Immunocytochemistry,Blockade of Receptor-ligand Interaction,CyTOF-ready

USD :

489 USD

alt names :

BDCA4, BDCA-4, CD304, CD304 antigen, DKFZp686A03134, DKFZp781F1414, neuropilin 1, neuropilin-1, Neuropilin1, NP1, NRP, NRP1, transmembrane receptor, Vascular endothelial cell growth factor 165 receptor, VEGF165R

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage