product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human PDGF R▀ Antibody
catalog :
AF385
quantity :
100 ug (also 25 ug)
price :
499 USD
clonality :
polyclonal
host :
domestic goat
conjugate :
nonconjugated
reactivity :
human, mouse, rhesus macaque
application :
western blot, immunohistochemistry, immunocytochemistry, neutralization, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 42
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - frozen section; human; 1:100; fig 1d
Andrews M, Mukhtar T, Eze U, Simoneau C, Perez Y, Mostajo Radji M, et al. Tropism of SARS-CoV-2 for Developing Human Cortical Astrocytes. bioRxiv. 2021;: pubmed publisher
Shi M, Crouse B, Sundaram N, Pode Shakked N, Ester L, Zhang W, et al. Integrating collecting systems in kidney organoids through fusion of distal nephron to ureteric bud. bioRxiv. 2024;: pubmed publisher
Liu M, Zhang C, Gong X, Zhang T, Lian M, Chew E, et al. Kidney organoid models reveal cilium-autophagy metabolic axis as a therapeutic target for PKD both in vitro and in vivo. Cell Stem Cell. 2024;31:52-70.e8 pubmed publisher
Monteil V, Kwon H, John L, Salata C, Jönsson G, Vorrink S, et al. Identification of CCZ1 as an essential lysosomal trafficking regulator in Marburg and Ebola virus infections. Nat Commun. 2023;14:6785 pubmed publisher
Choudhury A, Cady M, Lucas C, Najem H, Phillips J, Palikuqi B, et al. NOTCH3 drives meningioma tumorigenesis and resistance to radiotherapy. bioRxiv. 2023;: pubmed publisher
K xf8 murcu K, Wilhelmsen I, Thorne J, Krauss S, Wilson S, Aizenshtadt A, et al. Mass spectrometry reveals that oxysterols are secreted from non-alcoholic fatty liver disease induced organoids. J Steroid Biochem Mol Biol. 2023;232:106355 pubmed publisher
Wang T, Wang Y, Montero Pedrazuela A, Prensa L, Guada xf1 o Ferraz A, Rausell E. Thyroid Hormone Transporters MCT8 and OATP1C1 Are Expressed in Projection Neurons and Interneurons of Basal Ganglia and Motor Thalamus in the Adult Human and Macaque Brains. Int J Mol Sci. 2023;24: pubmed publisher
Ryoo H, Underhill G. Combinatorial Microgels for 3D ECM Screening and Heterogeneous Microenvironmental Culture of Primary Human Hepatic Stellate Cells. bioRxiv. 2023;: pubmed publisher
Shen M, Zhao S, Khokhar Y, Li L, Zhou Y, Liu C, et al. Protocol to generate cardiac pericytes from human induced pluripotent stem cells. STAR Protoc. 2023;4:102256 pubmed publisher
Mihali x10d F, Simonetti L, Giudice G, Sander M, Lindqvist R, Peters M, et al. Large-scale phage-based screening reveals extensive pan-viral mimicry of host short linear motifs. Nat Commun. 2023;14:2409 pubmed publisher
Hirunpattarasilp C, James G, Kwanthongdee J, Freitas F, Huo J, Sethi H, et al. SARS-CoV-2 triggers pericyte-mediated cerebral capillary constriction. Brain. 2023;146:727-738 pubmed publisher
Dieriks B, Highet B, Alik A, Bellande T, Stevenson T, Low V, et al. Human pericytes degrade diverse α-synuclein aggregates. PLoS ONE. 2022;17:e0277658 pubmed publisher
Cooper E, Woolf Z, Swanson M, Correia J, Schweder P, Mee E, et al. Single-cell image analysis reveals over-expression of organic anion transporting polypeptides (OATPs) in human glioblastoma tissue. Neurooncol Adv. 2022;4:vdac166 pubmed publisher
Zhou T, Li Y, Li X, Zeng F, Rao Y, He Y, et al. Microglial debris is cleared by astrocytes via C4b-facilitated phagocytosis and degraded via RUBICON-dependent noncanonical autophagy in mice. Nat Commun. 2022;13:6233 pubmed publisher
Carrella S, Di Guida M, Brillante S, Piccolo D, Ciampi L, Guadagnino I, et al. miR-181a/b downregulation: a mutation-independent therapeutic approach for inherited retinal diseases. EMBO Mol Med. 2022;14:e15941 pubmed publisher
Littau J, Velilla L, Hase Y, Villalba Moreno N, Hagel C, Drexler D, et al. Evidence of beta amyloid independent small vessel disease in familial Alzheimer's disease. Brain Pathol. 2022;32:e13097 pubmed publisher
Gupta N, Matsumoto T, Hiratsuka K, Garcia Saiz E, Galichon P, Miyoshi T, et al. Modeling injury and repair in kidney organoids reveals that homologous recombination governs tubular intrinsic repair. Sci Transl Med. 2022;14:eabj4772 pubmed publisher
Sarri N, Wang K, Tsioumpekou M, Castillejo L xf3 pez C, Lennartsson J, Heldin C, et al. Deubiquitinating enzymes USP4 and USP17 finetune the trafficking of PDGFRβ and affect PDGF-BB-induced STAT3 signalling. Cell Mol Life Sci. 2022;79:85 pubmed publisher
Mause S, Ritzel E, Deck A, Vogt F, Liehn E. Engagement of the CXCL12-CXCR4 Axis in the Interaction of Endothelial Progenitor Cell and Smooth Muscle Cell to Promote Phenotype Control and Guard Vascular Homeostasis. Int J Mol Sci. 2022;23: pubmed publisher
Ma S, Tang T, Wu X, Mansour A, Lu T, Zhang J, et al. PDGF-D-PDGFRβ signaling enhances IL-15-mediated human natural killer cell survival. Proc Natl Acad Sci U S A. 2022;119: pubmed publisher
Kaushik D, Bhattacharya A, Lozinski B, Wee Yong V. Pericytes as mediators of infiltration of macrophages in multiple sclerosis. J Neuroinflammation. 2021;18:301 pubmed publisher
Ding R, Hase Y, Burke M, Foster V, Stevenson W, Polvikoski T, et al. Loss with ageing but preservation of frontal cortical capillary pericytes in post-stroke dementia, vascular dementia and Alzheimer's disease. Acta Neuropathol Commun. 2021;9:130 pubmed publisher
Shi H, Koronyo Y, Fuchs D, Sheyn J, Wawrowsky K, Lahiri S, et al. Retinal capillary degeneration and blood-retinal barrier disruption in murine models of Alzheimer's disease. Acta Neuropathol Commun. 2020;8:202 pubmed publisher
Coate K, Cha J, Shrestha S, Wang W, Gonçalves L, Almaca J, et al. SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 Are Expressed in the Microvasculature and Ducts of Human Pancreas but Are Not Enriched in β Cells. Cell Metab. 2020;32:1028-1040.e4 pubmed publisher
Aladowicz E, Granieri L, Marocchi F, Punzi S, Giardina G, Ferrucci P, et al. ShcD Binds DOCK4, Promotes Ameboid Motility and Metastasis Dissemination, Predicting Poor Prognosis in Melanoma. Cancers (Basel). 2020;12: pubmed publisher
Di Marco B, Crouch E, Shah B, Duman C, Paredes M, Ruiz de Almodovar C, et al. Reciprocal Interaction between Vascular Filopodia and Neural Stem Cells Shapes Neurogenesis in the Ventral Telencephalon. Cell Rep. 2020;33:108256 pubmed publisher
Ding R, Hase Y, Ameen Ali K, Ndung u M, Stevenson W, Barsby J, et al. Loss of capillary pericytes and the blood-brain barrier in white matter in poststroke and vascular dementias and Alzheimer's disease. Brain Pathol. 2020;30:1087-1101 pubmed publisher
Shahidi B, Gibbons M, Esparza M, Zlomislic V, Allen R, Garfin S, et al. Cell populations and muscle fiber morphology associated with acute and chronic muscle degeneration in lumbar spine pathology. JOR Spine. 2020;3:e1087 pubmed publisher
Kang L, Yu H, Yang X, Zhu Y, Bai X, Wang R, et al. Neutrophil extracellular traps released by neutrophils impair revascularization and vascular remodeling after stroke. Nat Commun. 2020;11:2488 pubmed publisher
Sweeney M, Sagare A, Pachicano M, Harrington M, Joe E, Chui H, et al. A novel sensitive assay for detection of a biomarker of pericyte injury in cerebrospinal fluid. Alzheimers Dement. 2020;16:821-830 pubmed publisher
Rust R, Kirabali T, Grönnert L, Dogançay B, Limasale Y, Meinhardt A, et al. A Practical Guide to the Automated Analysis of Vascular Growth, Maturation and Injury in the Brain. Front Neurosci. 2020;14:244 pubmed publisher
Shi H, Koronyo Y, Rentsendorj A, Regis G, Sheyn J, Fuchs D, et al. Identification of early pericyte loss and vascular amyloidosis in Alzheimer's disease retina. Acta Neuropathol. 2020;139:813-836 pubmed publisher
Kirabali T, Rigotti S, Siccoli A, Liebsch F, Shobo A, Hock C, et al. The amyloid-β degradation intermediate Aβ34 is pericyte-associated and reduced in brain capillaries of patients with Alzheimer's disease. Acta Neuropathol Commun. 2019;7:194 pubmed publisher
Rajani R, Ratelade J, Domenga Denier V, Hase Y, Kalimo H, Kalaria R, et al. Blood brain barrier leakage is not a consistent feature of white matter lesions in CADASIL. Acta Neuropathol Commun. 2019;7:187 pubmed publisher
Low J, Li P, Chew E, Zhou B, Suzuki K, Zhang T, et al. Generation of Human PSC-Derived Kidney Organoids with Patterned Nephron Segments and a De Novo Vascular Network. Cell Stem Cell. 2019;25:373-387.e9 pubmed publisher
Wimmer R, Leopoldi A, Aichinger M, Wick N, Hantusch B, Novatchkova M, et al. Human blood vessel organoids as a model of diabetic vasculopathy. Nature. 2019;565:505-510 pubmed publisher
Nation D, Sweeney M, Montagne A, Sagare A, D Orazio L, Pachicano M, et al. Blood-brain barrier breakdown is an early biomarker of human cognitive dysfunction. Nat Med. 2019;25:270-276 pubmed publisher
Ma Q, Zhao Z, Sagare A, Wu Y, Wang M, Owens N, et al. Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism. Mol Neurodegener. 2018;13:57 pubmed publisher
Winkler E, Birk H, Burkhardt J, Chen X, Yue J, Guo D, et al. Reductions in brain pericytes are associated with arteriovenous malformation vascular instability. J Neurosurg. 2018;129:1464-1474 pubmed publisher
Liang T, Zhu L, Gao W, Gong M, Ren J, Yao H, et al. Coculture of endothelial progenitor cells and mesenchymal stem cells enhanced their proliferation and angiogenesis through PDGF and Notch signaling. FEBS Open Bio. 2017;7:1722-1736 pubmed publisher
Ha S, Lee M, Kurahashi M, Wei L, Jorgensen B, Park C, et al. Transcriptome analysis of PDGFRα+ cells identifies T-type Ca2+ channel CACNA1G as a new pathological marker for PDGFRα+ cell hyperplasia. PLoS ONE. 2017;12:e0182265 pubmed publisher
Schock E, Struve J, Chang C, Williams T, Snedeker J, Attia A, et al. A tissue-specific role for intraflagellar transport genes during craniofacial development. PLoS ONE. 2017;12:e0174206 pubmed publisher
product information
brand :
R&D Systems
master code :
AF385
SKU :
AF385
product name :
Human PDGF R▀ Antibody
unit size :
100 ug (also 25 ug)
seo description :
The Human PDGF Rß Antibody from R&D Systems is a goat polyclonal antibody to PDGF R beta. This antibody reacts with human,mouse,primate - macaca fascicularis (crab-eating monkey or cynomolgus macaque),primate - macaca mulatta (rhesus macaque),rabbit,primate - saimiri sciureus (common squirrel monkey). The Human PDGF Rß Antibody has been validated for the following applications: Immunocytochemistry,Western Blot,Neutralization,Immunohistochemistry,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Flow Cytometry,CyTOF-ready.
target :
PDGF R beta
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. See Certificate of Analysis for details. *Small pack size (-SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Polyclonal
concentration :
LYOPH
conjugate :
Unconjugated
dilution :
Western Blot 2 ug/mL, Flow Cytometry 0.25 ug/10^6 cells, Immunohistochemistry 5-15 ug/mL, Neutralization 10-40 ug/mL, CyTOF-ready
host :
Goat
immunogen :
Mouse myeloma cell line NS0-derived recombinant human PDGF R▀, Leu33-Phe530 (Glu241Asp), Accession # P09619
isotype :
IgG
purity :
Antigen Affinity-purified
species :
Human,Mouse,Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque),Primate - Macaca mulatta (Rhesus Macaque),Rabbit,Primate - Saimiri sciureus (Common Squirrel Monkey)
specificity :
Detects human PDGF R▀ in direct ELISAs and Western blots.
gene symbol :
PDGFRB
endotoxin note :
<0.10 EU per 1 ╡g of the antibody by the LAL method.
top caption :
PDGF Rss antibody in Human Breast Cancer Tissue by Immunohistochemistry (IHC-P).
accessionNumbers :
P09619
applications :
Flow Cytometry,CyTOF-ready,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Neutralization,Immunocytochemistry
USD :
499 USD
alt names :
beta-type platelet-derived growth factor receptor, CD140 antigen-like family member B, CD140b, CD140b antigen, EC 2.7.10, EC 2.7.10.1, JTK12, PDGFR, PDGFR1, PDGFRB, PDGF-R-beta, platelet-derived growth factor receptor, beta polypeptide
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.