Human/Mouse Smad2/3 Antibody | R&D Systems AF3797 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human/Mouse Smad2/3 Antibody

catalog :

AF3797

quantity :

100 ug (also 25 ug)

price :

509 USD

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, chromatin immunoprecipitation

more info or order :

R&D Systems product webpage

citations: 17

Reference
Militi S, Nibhani R, Jalali M, Pauklin S. RBL2-E2F-GCN5 guide cell fate decisions during tissue specification by regulating cell-cycle-dependent fluctuations of non-cell-autonomous signaling. Cell Rep. 2023;42:113146 pubmed publisher
Mouti M, Deng S, Pook M, Malzahn J, Rendek A, Militi S, et al. KMT2A associates with PHF5A-PHF14-HMG20A-RAI1 subcomplex in pancreatic cancer stem cells and epigenetically regulates their characteristics. Nat Commun. 2023;14:5685 pubmed publisher
Yoshida M, Kokubun T, Sato K, Tsuda S, Yokoyama Y, Himori N, et al. DPP-4 Inhibitors Attenuate Fibrosis After Glaucoma Filtering Surgery by Suppressing the TGF-β/Smad Signaling Pathway. Invest Ophthalmol Vis Sci. 2023;64:2 pubmed publisher
Razali R, Yazid M, Saim A, Idrus R, Lokanathan Y. Approaches in Hydroxytyrosol Supplementation on Epithelial-Mesenchymal Transition in TGFβ1-Induced Human Respiratory Epithelial Cells. Int J Mol Sci. 2023;24: pubmed publisher
Sisto M, Ribatti D, Ingravallo G, Lisi S. The Expression of Follistatin-like 1 Protein Is Associated with the Activation of the EMT Program in Sjögren's Syndrome. J Clin Med. 2022;11: pubmed publisher
Mather R, Parolia A, Carson S, Venalainen E, Roig Carles D, Jaber M, et al. The evolutionarily conserved long non-coding RNA LINC00261 drives neuroendocrine prostate cancer proliferation and metastasis via distinct nuclear and cytoplasmic mechanisms. Mol Oncol. 2021;15:1921-1941 pubmed publisher
Halder L, Jo E, Hasan M, Ferreira Gomes M, Krüger T, Westermann M, et al. Immune modulation by complement receptor 3-dependent human monocyte TGF-β1-transporting vesicles. Nat Commun. 2020;11:2331 pubmed publisher
Chen P, Qin L, Li G, Malagon Lopez J, Wang Z, Bergaya S, et al. Smooth Muscle Cell Reprogramming in Aortic Aneurysms. Cell Stem Cell. 2020;26:542-557.e11 pubmed publisher
Wang L, Li Y, Wang X, Wang P, Essandoh K, Cui S, et al. GDF3 Protects Mice against Sepsis-Induced Cardiac Dysfunction and Mortality by Suppression of Macrophage Pro-Inflammatory Phenotype. Cells. 2020;9: pubmed publisher
Sisto M, Lorusso L, Ingravallo G, Ribatti D, Lisi S. TGFβ1-Smad canonical and -Erk noncanonical pathways participate in interleukin-17-induced epithelial-mesenchymal transition in Sjögren's syndrome. Lab Invest. 2020;100:824-836 pubmed publisher
Jang J, Han D, Golkaram M, Audouard M, Liu G, Bridges D, et al. Control over single-cell distribution of G1 lengths by WNT governs pluripotency. PLoS Biol. 2019;17:e3000453 pubmed publisher
Gentsch G, Spruce T, Owens N, Smith J. Maternal pluripotency factors initiate extensive chromatin remodelling to predefine first response to inductive signals. Nat Commun. 2019;10:4269 pubmed publisher
He R, Wang M, Zhao C, Shen M, Yu Y, He L, et al. TFEB-driven autophagy potentiates TGF-β induced migration in pancreatic cancer cells. J Exp Clin Cancer Res. 2019;38:340 pubmed publisher
Nakai K, Karita S, Igarashi J, Tsukamoto I, Hirano K, Kubota Y. COA-Cl prevented TGF-β1-induced CTGF expression by Akt dephosphorylation in normal human dermal fibroblasts, and it attenuated skin fibrosis in mice models of systemic sclerosis. J Dermatol Sci. 2019;94:205-212 pubmed publisher
Bertero A, Brown S, Madrigal P, Osnato A, Ortmann D, Yiangou L, et al. The SMAD2/3 interactome reveals that TGFβ controls m6A mRNA methylation in pluripotency. Nature. 2018;555:256-259 pubmed publisher
Cheng T, Yue M, Aslam M, Wang X, Shekhawat G, Varani J, et al. Neuronal Protein 3.1 Deficiency Leads to Reduced Cutaneous Scar Collagen Deposition and Tensile Strength due to Impaired Transforming Growth Factor-Î²1 to -Î²3 Translation. Am J Pathol. 2017;187:292-303 pubmed publisher
Jadalannagari S, Berry A, Hopkins R, Bhavsar D, Aljitawi O. Potential mechanisms underlying ectodermal differentiation of Wharton's jelly mesenchymal stem cells. Biochem Biophys Res Commun. 2016;478:831-7 pubmed publisher

product information

master code :

AF3797

SKU :

AF3797

product name :

Human/Mouse Smad2/3 Antibody

unit size :

100 ug (also 25 ug)

description :

The Human/Mouse Smad2/3 Antibody from R&D Systems is a goat polyclonal antibody to Smad2/3. This antibody reacts with human,mouse,rat,frog - xenopus (african clawed frog). The Human/Mouse Smad2/3 Antibody has been validated for the following applications: Flow Cytometry,Immunoprecipitation,Western Blot,Simple Western,Immunohistochemistry,Chromatin Immunoprecipitation (ChIP),Immunocytochemistry.

target :

Smad2/3

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Polyclonal

concentration :

LYOPH

conjugate :

Unconjugated

host :

Goat

immunogen :

E. coli -derived recombinant human Smad3, Ser2-Ala230, Accession # P84022

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Human,Mouse,Rat,Frog - Xenopus (African Clawed Frog)

specificity :

Detects human, mouse, and rat Smad2/3 in Western blots. Predicted to detect rat based on sequence homology.

gene symbol :

SMAD2

top caption :

Detection of Human/Mouse Smad2/3 antibody by Western Blot.

accessionNumbers :

P84022

applications :

Flow Cytometry,Immunoprecipitation,Western Blot,Simple Western,Immunohistochemistry,Chromatin Immunoprecipitation (ChIP),Immunocytochemistry

USD :

509 USD

alt names :

hMAD-2, hSMAD2, JV18, JV18-1, JV18-1SMAD, mothers against DPP homolog 2 (Drosophila), MAD homolog 2, Mad protein homolog, Mad, mothers against decapentaplegic homolog 2, MADH2, MADH2MGC34440, MADR2, MADR2MGC22139, Mad-related protein 2, mother against DPP homolog 2, mothers against decapentaplegic homolog 2, Mothers against DPP homolog 2, Sma- and Mad-related protein 2, SMAD 2, SMAD family member 2MAD, mothers against decapentaplegic homolog 2 (Drosophila), SMAD, mothers against DPP homolog 2, Smad2, Smox

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage