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company name :
R&D Systems
product type :
antibody
product name :
Human/Mouse KLF5 Antibody
catalog :
AF3758
quantity :
100 ug (also 25 ug)
price :
499 USD
clonality :
polyclonal
host :
domestic goat
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, chromatin immunoprecipitation, immunohistochemistry - paraffin section
more info or order :
R&D Systems product webpage
citations: 15
Reference
Alavi M, Mejia Bautista A, Tang M, Bandovic J, Rosenberg A, Bialkowska A. Krüppel-like Factor 5 Plays an Important Role in the Pathogenesis of Chronic Pancreatitis. Cancers (Basel). 2023;15: pubmed publisher
Zhao P, Sun J, Huang X, Zhang X, Liu X, Liu R, et al. Targeting the KLF5-EphA2 axis can restrain cancer stemness and overcome chemoresistance in basal-like breast cancer. Int J Biol Sci. 2023;19:1861-1874 pubmed publisher
Wu Q, Liu Z, Gao Z, Luo Y, Li F, Yang C, et al. KLF5 inhibition potentiates anti-PD1 efficacy by enhancing CD8+ T-cell-dependent antitumor immunity. Theranostics. 2023;13:1381-1400 pubmed publisher
Fukuchi K, Nanai K, Yuita H, Maru C, Tsukada J, Ishigami M, et al. Novel Antibody Exerts Antitumor Effect through Downregulation of CD147 and Activation of Multiple Stress Signals. J Oncol. 2022;2022:3552793 pubmed publisher
Kong Y, Ren W, Fang H, Shah N, Shi Y, You D, et al. Histone Deacetylase Inhibitors (HDACi) Promote KLF5 Ubiquitination and Degradation in Basal-like Breast Cancer. Int J Biol Sci. 2022;18:2104-2115 pubmed publisher
Huang S, Kuri P, Aubert Y, Brewster M, Li N, Farrelly O, et al. Lgr6 marks epidermal stem cells with a nerve-dependent role in wound re-epithelialization. Cell Stem Cell. 2021;28:1582-1596.e6 pubmed publisher
Li J, Zhang B, Liu M, Fu X, Ci X, A J, et al. KLF5 Is Crucial for Androgen-AR Signaling to Transactivate Genes and Promote Cell Proliferation in Prostate Cancer Cells. Cancers (Basel). 2020;12: pubmed publisher
Hogrebe N, Augsornworawat P, Maxwell K, Velazco Cruz L, Millman J. Targeting the cytoskeleton to direct pancreatic differentiation of human pluripotent stem cells. Nat Biotechnol. 2020;38:460-470 pubmed publisher
Ge Y, Miao Y, Gur Cohen S, Gomez N, Yang H, Nikolova M, et al. The aging skin microenvironment dictates stem cell behavior. Proc Natl Acad Sci U S A. 2020;117:5339-5350 pubmed publisher
Wang Y, Lifshitz L, Gellatly K, Vinton C, Busman Sahay K, McCauley S, et al. HIV-1-induced cytokines deplete homeostatic innate lymphoid cells and expand TCF7-dependent memory NK cells. Nat Immunol. 2020;21:274-286 pubmed publisher
Kim C, Saxena M, Maharjan K, Song J, Shroyer K, Bialkowska A, et al. Krüppel-like Factor 5 Regulates Stemness, Lineage Specification, and Regeneration of Intestinal Epithelial Stem Cells. Cell Mol Gastroenterol Hepatol. 2020;9:587-609 pubmed publisher
Wu Y, Qin J, Li F, Yang C, Li Z, Zhou Z, et al. USP3 promotes breast cancer cell proliferation by deubiquitinating KLF5. J Biol Chem. 2019;294:17837-17847 pubmed publisher
Tao R, Zhang B, Li Y, King J, Tian R, Xia S, et al. HDAC-mediated deacetylation of KLF5 associates with its proteasomal degradation. Biochem Biophys Res Commun. 2018;500:777-782 pubmed publisher
Ge Y, Gomez N, Adam R, Nikolova M, Yang H, Verma A, et al. Stem Cell Lineage Infidelity Drives Wound Repair and Cancer. Cell. 2017;169:636-650.e14 pubmed publisher
Zhang W, Hong S, Maniar K, Cheng S, Jie C, Rademaker A, et al. KLF13 regulates the differentiation-dependent human papillomavirus life cycle in keratinocytes through STAT5 and IL-8. Oncogene. 2016;35:5565-5575 pubmed publisher
product information
brand :
R&D Systems
master code :
AF3758
SKU :
AF3758
product name :
Human/Mouse KLF5 Antibody
unit size :
100 ug (also 25 ug)
seo description :
The Human/Mouse KLF5 Antibody from R&D Systems is a goat polyclonal antibody to KLF5. This antibody reacts with human,mouse. The Human/Mouse KLF5 Antibody has been validated for the following applications: mmunoprecipitation,Immunoprecipitation,Western Blot,Immunohistochemistry,Immunohistochemistry-Paraffin,Chromatin Immunoprecipitation (ChIP),Immunocytochemistry,Simple Western,Knockout Validated.
target :
KLF5
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Polyclonal
concentration :
LYOPH
conjugate :
Unconjugated
dilution :
Western Blot 1 ug/mL, Simple Western 10 ug/mL, Immunocytochemistry 5-15 ug/mL, Knockout Validated
host :
Goat
immunogen :
E. coli -derived recombinant human KLF5, Leu85-Ala177, Accession # Q13887
isotype :
IgG
purity :
Antigen Affinity-purified
species :
Human,Mouse
specificity :
Detects human and mouse KLF5 in Western blots. In direct ELISAs and Western blots, less than 5% cross-reactivity with recombinant human (rh) KLF4, rhKLF6, recombinant mouse (rm) KLF4 and rmKLF15 is observed.
gene symbol :
KLF5
Antibody validation :
Knockout/Knockdown
top caption :
Detection of Human and Mouse KLF5 antibody by Western Blot.
accessionNumbers :
Q13887
applications :
Simple Western,Knockout Validated,mmunoprecipitation,Immunohistochemistry,Immunoprecipitation,Western Blot,Immunohistochemistry-Paraffin,Chromatin Immunoprecipitation (ChIP),Immunocytochemistry
USD :
499 USD
alt names :
Basic transcription element-binding protein 2, BTEB2, BTE-binding protein 2, CKLFGC-box-binding protein 2, Colon krueppel-like factor, colon kruppel-like factor, GC box binding protein 2, IKLFbasic transcription element binding protein 2, Intestinal-enriched krueppel-like factor, intestinal-enriched kruppel-like factor, Krueppel-like factor 5, Kruppel-like factor 5 (intestinal), Transcription factor BTEB2
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.