Human MANF Antibody | R&D Systems AF3748 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human MANF Antibody

catalog :

AF3748

quantity :

100 ug (also 25 ug)

price :

499 USD

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA, immunocytochemistry, immunoprecipitation

more info or order :

R&D Systems product webpage

citations: 7

Reference
Anttila J, Mattila O, Liew H, M xe4 tlik K, Mervaala E, Lindholm P, et al. MANF protein expression is upregulated in immune cells in the ischemic human brain and systemic recombinant MANF delivery in rat ischemic stroke model demonstrates anti-inflammatory effects. Acta Neuropathol Commun. 2024;12:10 pubmed publisher
Kovaleva V, Yu L, Ivanova L, Shpironok O, Nam J, Eesmaa A, et al. MANF regulates neuronal survival and UPR through its ER-located receptor IRE1α. Cell Rep. 2023;42:112066 pubmed publisher
Eesmaa A, Yu L, G xf6 xf6 s H, Danilova T, N xf5 ges K, Pakarinen E, et al. CDNF Interacts with ER Chaperones and Requires UPR Sensors to Promote Neuronal Survival. Int J Mol Sci. 2022;23: pubmed publisher
Konovalova J, Gerasymchuk D, Arroyo S, Kluske S, Mastroianni F, Pereyra A, et al. Human-Specific Regulation of Neurotrophic Factors MANF and CDNF by microRNAs. Int J Mol Sci. 2021;22: pubmed publisher
Danilova T, Galli E, Pakarinen E, Palm E, Lindholm P, Saarma M, et al. Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Is Highly Expressed in Mouse Tissues With Metabolic Function. Front Endocrinol (Lausanne). 2019;10:765 pubmed publisher
Galli E, Rossi J, Neumann T, Andressoo J, Drinda S, Lindholm P. Mesencephalic Astrocyte-Derived Neurotrophic Factor Is Upregulated with Therapeutic Fasting in Humans and Diet Fat Withdrawal in Obese Mice. Sci Rep. 2019;9:14318 pubmed publisher
Galli E, Planken A, Kadastik Eerme L, Saarma M, Taba P, Lindholm P. Increased Serum Levels of Mesencephalic Astrocyte-Derived Neurotrophic Factor in Subjects With Parkinson's Disease. Front Neurosci. 2019;13:929 pubmed publisher

product information

master code :

AF3748

SKU :

AF3748

product name :

Human MANF Antibody

unit size :

100 ug (also 25 ug)

description :

The Human MANF Antibody from R&D Systems is a goat polyclonal antibody to MANF. This antibody reacts with human,mouse,rat. The Human MANF Antibody has been validated for the following applications: ELISA Capture,Immunoprecipitation,Western Blot,Immunocytochemistry,Simple Western,Knockout Validated.

target :

MANF

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Polyclonal

concentration :

LYOPH

conjugate :

Unconjugated

host :

Goat

immunogen :

Mouse myeloma cell line NS0-derived recombinant human MANF, Leu22-Leu179, Accession # P55145

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Human,Mouse,Rat

specificity :

Detects human MANF in direct ELISAs and Western blots.

gene symbol :

MANF

Antibody validation :

Knockout/Knockdown

accessionNumbers :

P55145

applications :

Immunoprecipitation,Western Blot,ELISA Capture,Immunocytochemistry,Simple Western,Knockout Validated

USD :

499 USD

alt names :

Arginine-Rich Protein, arginine-rich, mutated in early stage tumors, ARMET, ARP, mesencephalic astrocyte-derived neurotrophic factor, Protein ARMET

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage