Human ALK-1 Antibody | R&D Systems AF370 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human ALK-1 Antibody

catalog :

AF370

quantity :

100 ug (also 25 ug)

price :

509 USD

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry, neutralization, immunoprecipitation, flow cytometry, immunohistochemistry - frozen section

more info or order :

R&D Systems product webpage

citations: 7

Reference
Jo S, Lee S, Jeon C, Jo H, Ko E, Whangbo M, et al. Elevated BMPR2 expression amplifies osteoblast differentiation in ankylosing spondylitis. J Rheum Dis. 2023;30:243-250 pubmed publisher
Iwasa T, Urasaki A, Kakihana Y, Nagata Akaho N, Harada Y, Takeda S, et al. Computational and Experimental Analyses for Pathogenicity Prediction of ACVRL1 Missense Variants in Hereditary Hemorrhagic Telangiectasia. J Clin Med. 2023;12: pubmed publisher
Andersson Rusch C, Liu B, Quist L xf8 kken I, Upton P, Olsen O, Hella H, et al. High concentrations of soluble endoglin can inhibit BMP9 signaling in non-endothelial cells. Sci Rep. 2023;13:6639 pubmed publisher
Jaykumar A, Plumber S, Barry D, Binns D, Wichaidit C, Grzemska M, et al. WNK1 collaborates with TGF-β in endothelial cell junction turnover and angiogenesis. Proc Natl Acad Sci U S A. 2022;119:e2203743119 pubmed publisher
Tao B, Kraehling J, Ghaffari S, Ramírez C, Lee S, Fowler J, et al. BMP-9 and LDL crosstalk regulates ALK-1 endocytosis and LDL transcytosis in endothelial cells. J Biol Chem. 2020;295:18179-18188 pubmed publisher
Toyonaga T, Steinbach E, Keith B, Barrow J, Schaner M, Wolber E, et al. Decreased Colonic Activin Receptor-Like Kinase 1 Disrupts Epithelial Barrier Integrity in Patients With Crohn's Disease. Cell Mol Gastroenterol Hepatol. 2020;10:779-796 pubmed publisher
Viallard C, Audiger C, Popovic N, Akla N, Lanthier K, Legault Navarrete I, et al. BMP9 signaling promotes the normalization of tumor blood vessels. Oncogene. 2020;39:2996-3014 pubmed publisher

product information

master code :

AF370

SKU :

AF370

product name :

Human ALK-1 Antibody

unit size :

100 ug (also 25 ug)

description :

The Human ALK-1 Antibody from R&D Systems is a goat polyclonal antibody to ALK-1. This antibody reacts with human,mouse,rat,transgenic mouse. The Human ALK-1 Antibody has been validated for the following applications: Western Blot,Immunocytochemistry,Flow Cytometry,Immunoprecipitation,Surface Plasmon Resonance,Neutralization,Immunohistochemistry-Frozen.

target :

ALK-1

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. See Certificate of Analysis for details. *Small pack size (-SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Polyclonal

concentration :

LYOPH

conjugate :

Unconjugated

host :

Goat

immunogen :

Mouse myeloma cell line NS0-derived recombinant human ALK-1, Asp22-Gln118, Accession # P37023

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Human,Mouse,Rat,Transgenic Mouse

specificity :

Detects human ALK-1 in direct ELISAs and Western blots. In direct ELISAs and Western blots, approximately 10% cross-reactivity with recombinant mouse ALK-1 is observed and less than 1% cross-reactivity with recombinant human (rh) Activin RIA and rhActivin RIB is observed.

gene symbol :

ACVRL1

accessionNumbers :

P37023

applications :

Flow Cytometry,Immunoprecipitation,Western Blot,Surface Plasmon Resonance,Neutralization,Immunohistochemistry-Frozen,Immunocytochemistry

USD :

509 USD

alt names :

activin A receptor type II-like 1, activin A receptor, type II-like kinase 1, Activin receptor-like kinase 1, ACVRL1, ACVRLK1ORW2, ALK1, ALK-1, ALK1TGF-B superfamily receptor type I, EC 2.7.11, HHT, HHT2EC 2.7.11.30, serine/threonine-protein kinase receptor R3, SKR3, TSR-I

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage