| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot; human; 1:1000; loading ...; fig 3a
| Han B, Sun Z, Yu T, Wang Y, Kuang L, Li T, et al. SPOP-PTEN-SUFU axis promotes progression of clear cell renal cell carcinoma via activating SHH and WNT pathway. Cell Death Discov. 2021;7:120 pubmed publisher |
- western blot; mouse; loading ...; fig 3g
| Koeniger A, Brichkina A, Nee I, Dempwolff L, Hupfer A, Galperin I, et al. Activation of Cilia-Independent Hedgehog/GLI1 Signaling as a Novel Concept for Neuroblastoma Therapy. Cancers (Basel). 2021;13: pubmed publisher |
- immunocytochemistry; mouse; 1:1000; loading ...
| Turn R, Linnert J, Gigante E, Wolfrum U, Caspary T, Kahn R. Roles for ELMOD2 and Rootletin in ciliogenesis. Mol Biol Cell. 2021;32:800-822 pubmed publisher |
| Deng Z, Rong S, Gan L, Wang F, Bao L, Cai F, et al. Temporal transcriptome features identify early skeletal commitment during human epiphysis development at single-cell resolution. iScience. 2023;26:107200 pubmed publisher |
| Bagka M, Choi H, H xe9 ritier M, Schwaemmle H, Pasquer Q, Braun S, et al. Targeted protein degradation reveals BET bromodomains as the cellular target of Hedgehog pathway inhibitor-1. Nat Commun. 2023;14:3893 pubmed publisher |
| Hor xe1 k P, Kreisingerov xe1 K, R xe9 da J, Ondru x161 ov xe1 L, Balko J, x17d xe1 kov xe1 P, et al. The Hedgehog/GLI signaling pathway activates transcription of Slug (Snail2) in melanoma cells. Oncol Rep. 2023;49: pubmed publisher |
| Fleck J, Jansen S, Wollny D, Zenk F, Seimiya M, Jain A, et al. Inferring and perturbing cell fate regulomes in human brain organoids. Nature. 2022;: pubmed publisher |
| Kurtovi x107 M, Pite x161 a N, Bartoni x10d ek N, Ozreti x107 P, Musani V, x10c onka x161 J, et al. RNA-seq and ChIP-seq Identification of Unique and Overlapping Targets of GLI Transcription Factors in Melanoma Cell Lines. Cancers (Basel). 2022;14: pubmed publisher |
| Rowton M, Perez Cervantes C, Hur S, Jacobs Li J, Lu E, Deng N, et al. Hedgehog signaling activates a mammalian heterochronic gene regulatory network controlling differentiation timing across lineages. Dev Cell. 2022;57:2181-2203.e9 pubmed publisher |
| Zhu J, Patel R, Trofka A, Harfe B, Mackem S. Sonic hedgehog is not a limb morphogen but acts as a trigger to specify all digits in mice. Dev Cell. 2022;57:2048-2062.e4 pubmed publisher |
| Schmidt S, Luecken M, Tr xfc mbach D, Hembach S, Niedermeier K, Wenck N, et al. Primary cilia and SHH signaling impairments in human and mouse models of Parkinson's disease. Nat Commun. 2022;13:4819 pubmed publisher |
| Schembs L, Willems A, Hasenpusch Theil K, Cooper J, Whiting K, Burr K, et al. The ciliary gene INPP5E confers dorsal telencephalic identity to human cortical organoids by negatively regulating Sonic hedgehog signaling. Cell Rep. 2022;39:110811 pubmed publisher |
| Juuri E, Tikka P, Domanskyi A, Corfe I, Morita W, McKinnon P, et al. Ptch2 is a Potential Regulator of Mesenchymal Stem Cells. Front Physiol. 2022;13:877565 pubmed publisher |
| Dewees S, Vargov xe1 R, Hardin K, Turn R, Devi S, Linnert J, et al. Phylogenetic profiling and cellular analyses of ARL16 reveal roles in traffic of IFT140 and INPP5E. Mol Biol Cell. 2022;33:ar33 pubmed publisher |
| Sun J, Yoon J, Lee M, Lee H, Hwang Y, Daar I. Zic5 stabilizes Gli3 via a non-transcriptional mechanism during retinal development. Cell Rep. 2022;38:110312 pubmed publisher |
| Turn R, Hu Y, Dewees S, Devi N, East M, Hardin K, et al. The ARF GAPs ELMOD1 and ELMOD3 act at the Golgi and cilia to regulate ciliogenesis and ciliary protein traffic. Mol Biol Cell. 2022;33:ar13 pubmed publisher |
| Sharma D, Mirando A, Leinroth A, Long J, Karner C, Hilton M. HES1 is a novel downstream modifier of the SHH-GLI3 Axis in the development of preaxial polydactyly. PLoS Genet. 2021;17:e1009982 pubmed publisher |
| Trofka A, Huang B, Zhu J, Heinz W, Magidson V, Shibata Y, et al. Genetic basis for an evolutionary shift from ancestral preaxial to postaxial limb polarity in non-urodele vertebrates. Curr Biol. 2021;31:4923-4934.e5 pubmed publisher |
| Boschen K, Fish E, Parnell S. Prenatal alcohol exposure disrupts Sonic hedgehog pathway and primary cilia genes in the mouse neural tube. Reprod Toxicol. 2021;105:136-147 pubmed publisher |
| Zhang Y, Hao J, Tarragó M, Warner G, Giorgadze N, Wei Q, et al. FBF1 deficiency promotes beiging and healthy expansion of white adipose tissue. Cell Rep. 2021;36:109481 pubmed publisher |
| Hwang S, Somatilaka B, White K, Mukhopadhyay S. Ciliary and extraciliary Gpr161 pools repress hedgehog signaling in a tissue-specific manner. elife. 2021;10: pubmed publisher |
| Chang C, Brown K, Yang Y, Brugmann S. Centriolar Protein C2cd3 Is Required for Craniofacial Development. Front Cell Dev Biol. 2021;9:647391 pubmed publisher |
| Chen C, Xu Q, Zhang Y, Davies B, Huang Y, Katzmann D, et al. Ciliopathy protein HYLS1 coordinates the biogenesis and signaling of primary cilia by activating the ciliary lipid kinase PIPKIγ. Sci Adv. 2021;7: pubmed publisher |
| Truong M, Bilekova S, Choksi S, Li W, Bugaj L, Xu K, et al. Vertebrate cells differentially interpret ciliary and extraciliary cAMP. Cell. 2021;184:2911-2926.e18 pubmed publisher |
| May E, Kalocsay M, D Auriac I, Schuster P, Gygi S, Nachury M, et al. Time-resolved proteomics profiling of the ciliary Hedgehog response. J Cell Biol. 2021;220: pubmed publisher |
| Mournetas V, Massourid xe8 s E, Dupont J, Kornobis E, Polv xe8 che H, Jarrige M, et al. Myogenesis modelled by human pluripotent stem cells: a multi-omic study of Duchenne myopathy early onset. J Cachexia Sarcopenia Muscle. 2021;12:209-232 pubmed publisher |
| Elliott K, Chen X, Salomone J, Chaturvedi P, Schultz P, Balchand S, et al. Gli3 utilizes Hand2 to synergistically regulate tissue-specific transcriptional networks. elife. 2020;9: pubmed publisher |
| Dias J, Alekseenko Z, Jeggari A, Boareto M, Vollmer J, Kozhevnikova M, et al. A Shh/Gli-driven three-node timer motif controls temporal identity and fate of neural stem cells. Sci Adv. 2020;6: pubmed publisher |
| Hasenpusch Theil K, Laclef C, Colligan M, Fitzgerald E, Howe K, Carroll E, et al. A transient role of the ciliary gene Inpp5e in controlling direct versus indirect neurogenesis in cortical development. elife. 2020;9: pubmed publisher |
| Yoshida S, Aoki K, Fujiwara K, Nakakura T, Kawamura A, Yamada K, et al. The novel ciliogenesis regulator DYRK2 governs Hedgehog signaling during mouse embryogenesis. elife. 2020;9: pubmed publisher |
| Freisleben F, Behrmann L, Thaden V, Muschhammer J, Bokemeyer C, Fiedler W, et al. Downregulation of GLI3 Expression Mediates Chemotherapy Resistance in Acute Myeloid Leukemia. Int J Mol Sci. 2020;21: pubmed publisher |
| Somatilaka B, Hwang S, Palicharla V, White K, Badgandi H, Shelton J, et al. Ankmy2 Prevents Smoothened-Independent Hyperactivation of the Hedgehog Pathway via Cilia-Regulated Adenylyl Cyclase Signaling. Dev Cell. 2020;: pubmed publisher |
| Chottekalapanda R, Kalik S, Gresack J, Ayala A, Gao M, Wang W, et al. AP-1 controls the p11-dependent antidepressant response. Mol Psychiatry. 2020;25:1364-1381 pubmed publisher |
| Yan H, Chen C, Chen H, Hong H, Huang Y, Ling K, et al. TALPID3 and ANKRD26 selectively orchestrate FBF1 localization and cilia gating. Nat Commun. 2020;11:2196 pubmed publisher |
| Kim Y, Lee J, Seppala M, Cobourne M, Kim S. Ptch2/Gas1 and Ptch1/Boc differentially regulate Hedgehog signalling in murine primordial germ cell migration. Nat Commun. 2020;11:1994 pubmed publisher |
| Hom M, Ondrus A, Sakata Kato T, Rack P, Chen J. Bicyclic Imidazolium Inhibitors of Gli Transcription Factor Activity. ChemMedChem. 2020;15:1044-1049 pubmed publisher |
| Chen K, Tahara N, Anderson A, Kawakami H, Kawakami S, Nishinakamura R, et al. Development of the Proximal-Anterior Skeletal Elements in the Mouse Hindlimb Is Regulated by a Transcriptional and Signaling Network Controlled by Sall4. Genetics. 2020;215:129-141 pubmed publisher |
| Gigante E, Taylor M, Ivanova A, Kahn R, Caspary T. ARL13B regulates Sonic hedgehog signaling from outside primary cilia. elife. 2020;9: pubmed publisher |
| Liu P, Dodson M, Fang D, Chapman E, Zhang D. NRF2 negatively regulates primary ciliogenesis and hedgehog signaling. PLoS Biol. 2020;18:e3000620 pubmed publisher |
| Constable S, Long A, Floyd K, Schurmans S, Caspary T. The ciliary phosphatidylinositol phosphatase Inpp5e plays positive and negative regulatory roles in Shh signaling. Development. 2020;147: pubmed publisher |
| Bastida M, Pérez Gómez R, Trofka A, Zhu J, Rada Iglesias A, Sheth R, et al. The formation of the thumb requires direct modulation of Gli3 transcription by Hoxa13. Proc Natl Acad Sci U S A. 2020;117:1090-1096 pubmed publisher |
| Taroc E, Naik A, Lin J, Peterson N, Keefe D, Genis E, et al. Gli3 Regulates Vomeronasal Neurogenesis, Olfactory Ensheathing Cell Formation, and GnRH-1 Neuronal Migration. J Neurosci. 2020;40:311-326 pubmed publisher |
| Martin Hurtado A, Martin Morales R, Robledinos Antón N, Blanco R, Palacios Blanco I, Lastres Becker I, et al. NRF2-dependent gene expression promotes ciliogenesis and Hedgehog signaling. Sci Rep. 2019;9:13896 pubmed publisher |
| Bufalieri F, Infante P, Bernardi F, Caimano M, Romania P, Moretti M, et al. ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP. Nat Commun. 2019;10:3304 pubmed publisher |
| Nam H, Jeon S, An H, Yoo J, Lee H, Lee S, et al. Critical roles of ARHGAP36 as a signal transduction mediator of Shh pathway in lateral motor columnar specification. elife. 2019;8: pubmed publisher |
| Ma P, Song N, Li Y, Zhang Q, Zhang L, Zhang L, et al. Fine-Tuning of Shh/Gli Signaling Gradient by Non-proteolytic Ubiquitination during Neural Patterning. Cell Rep. 2019;28:541-553.e4 pubmed publisher |
| Han Y, Wang B, Cho Y, Zhu J, Wu J, Chen Y, et al. Phosphorylation of Ci/Gli by Fused Family Kinases Promotes Hedgehog Signaling. Dev Cell. 2019;50:610-626.e4 pubmed publisher |
| Adams C, Htwe H, Marsh T, Wang A, Montoya M, Subbaraj L, et al. Transcriptional control of subtype switching ensures adaptation and growth of pancreatic cancer. elife. 2019;8: pubmed publisher |
| Kiseleva A, Korobeynikov V, Nikonova A, Zhang P, Makhov P, Deneka A, et al. Unexpected Activities in Regulating Ciliation Contribute to Off-target Effects of Targeted Drugs. Clin Cancer Res. 2019;: pubmed publisher |
| Choi Y, Halbritter J, Braun D, Schueler M, Schapiro D, Rim J, et al. Mutations of ADAMTS9 Cause Nephronophthisis-Related Ciliopathy. Am J Hum Genet. 2019;104:45-54 pubmed publisher |
| Massa F, Tammaro R, Prado M, Cesana M, Lee B, Finley D, et al. The deubiquitinating enzyme Usp14 controls ciliogenesis and Hedgehog signaling. Hum Mol Genet. 2019;28:764-777 pubmed publisher |
| He K, Ma X, Xu T, Li Y, Hodge A, Zhang Q, et al. Axoneme polyglutamylation regulated by Joubert syndrome protein ARL13B controls ciliary targeting of signaling molecules. Nat Commun. 2018;9:3310 pubmed publisher |
| Hong S, Wang C, Huang Y, Chang Y, Chang Y, Pusapati G, et al. Spatiotemporal manipulation of ciliary glutamylation reveals its roles in intraciliary trafficking and Hedgehog signaling. Nat Commun. 2018;9:1732 pubmed publisher |
| Rosengren T, Larsen L, Pedersen L, Christensen S, Møller L. TSC1 and TSC2 regulate cilia length and canonical Hedgehog signaling via different mechanisms. Cell Mol Life Sci. 2018;75:2663-2680 pubmed publisher |
| Struchtrup A, Wiegering A, Stork B, Ruther U, Gerhardt C. The ciliary protein RPGRIP1L governs autophagy independently of its proteasome-regulating function at the ciliary base in mouse embryonic fibroblasts. Autophagy. 2018;14:567-583 pubmed publisher |
| Gonnissen A, Isebaert S, Perneel C, McKee C, Van Utterbeeck F, Lerut E, et al. Patched 1 Expression Correlates with Biochemical Relapse in High-Risk Prostate Cancer Patients. Am J Pathol. 2018;188:795-804 pubmed publisher |
| Veistinen L, Mustonen T, Hasan M, Takatalo M, Kobayashi Y, Kesper D, et al. Regulation of Calvarial Osteogenesis by Concomitant De-repression of GLI3 and Activation of IHH Targets. Front Physiol. 2017;8:1036 pubmed publisher |
| Guen V, Chavarria T, Kröger C, Ye X, Weinberg R, Lees J. EMT programs promote basal mammary stem cell and tumor-initiating cell stemness by inducing primary ciliogenesis and Hedgehog signaling. Proc Natl Acad Sci U S A. 2017;114:E10532-E10539 pubmed publisher |
| Hasegawa D, Ochiai Shino H, Onodera S, Nakamura T, Saito A, Onda T, et al. Gorlin syndrome-derived induced pluripotent stem cells are hypersensitive to hedgehog-mediated osteogenic induction. PLoS ONE. 2017;12:e0186879 pubmed publisher |
| Li J, Cui Y, Xu J, Wang Q, Yang X, Li Y, et al. Suppressor of Fused restraint of Hedgehog activity level is critical for osteogenic proliferation and differentiation during calvarial bone development. J Biol Chem. 2017;292:15814-15825 pubmed publisher |
| Han Y, Xiong Y, Shi X, Wu J, Zhao Y, Jiang J. Regulation of Gli ciliary localization and Hedgehog signaling by the PY-NLS/karyopherin-?2 nuclear import system. PLoS Biol. 2017;15:e2002063 pubmed publisher |
| Hoelzl M, Heby Henricson K, Gerling M, Dias J, Kuiper R, Trünkle C, et al. Differential requirement of SUFU in tissue development discovered in a hypomorphic mouse model. Dev Biol. 2017;429:132-146 pubmed publisher |
| Arensdorf A, Dillard M, Menke J, Frank M, Rock C, Ogden S. Sonic Hedgehog Activates Phospholipase A2 to Enhance Smoothened Ciliary Translocation. Cell Rep. 2017;19:2074-2087 pubmed publisher |
| Cai H, Liu A. Spop regulates Gli3 activity and Shh signaling in dorsoventral patterning of the mouse spinal cord. Dev Biol. 2017;432:72-85 pubmed publisher |
| Phua S, Chiba S, Suzuki M, Su E, Roberson E, Pusapati G, et al. Dynamic Remodeling of Membrane Composition Drives Cell Cycle through Primary Cilia Excision. Cell. 2017;168:264-279.e15 pubmed publisher |
| Makino S, Fukumura R, Gondo Y. Illegitimate translation causes unexpected gene expression from on-target out-of-frame alleles created by CRISPR-Cas9. Sci Rep. 2016;6:39608 pubmed publisher |
| Cai H, Liu A. Spop promotes skeletal development and homeostasis by positively regulating Ihh signaling. Proc Natl Acad Sci U S A. 2016;113:14751-14756 pubmed publisher |
| Chang C, Chang Y, Millington G, Brugmann S. Craniofacial Ciliopathies Reveal Specific Requirements for GLI Proteins during Development of the Facial Midline. PLoS Genet. 2016;12:e1006351 pubmed publisher |
| Luchetti G, Sircar R, Kong J, Nachtergaele S, Sagner A, Byrne E, et al. Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling. elife. 2016;5: pubmed publisher |
| Tukachinsky H, Petrov K, Watanabe M, Salic A. Mechanism of inhibition of the tumor suppressor Patched by Sonic Hedgehog. Proc Natl Acad Sci U S A. 2016;113:E5866-E5875 pubmed |
| Emechebe U, Kumar P P, Rozenberg J, Moore B, Firment A, Mirshahi T, et al. T-box3 is a ciliary protein and regulates stability of the Gli3 transcription factor to control digit number. elife. 2016;5: pubmed publisher |
