product summary
Loading...
company name :
R&D Systems
product type :
antibody
product name :
Human/Mouse Myeloperoxidase/MPO Antibody
catalog :
AF3667
quantity :
100 ug (also 25 ug)
price :
509 USD
clonality :
polyclonal
host :
domestic goat
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 145
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - frozen section; human; loading ...; fig 9a
  • immunohistochemistry - frozen section; mouse; loading ...; fig 7b
Yau A, Globisch M, Onyeogaziri F, Conze L, Smith R, Jauhiainen S, et al. Inflammation and neutrophil extracellular traps in cerebral cavernous malformation. Cell Mol Life Sci. 2022;79:206 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 2m
Yang Y, Cai F, Zhou N, Liu S, Wang P, Zhang S, et al. Dimethyl fumarate prevents ferroptosis to attenuate acute kidney injury by acting on NRF2. Clin Transl Med. 2021;11:e382 pubmed publisher
  • immunohistochemistry; mouse; 1:100; loading ...; fig 5c
Kucsera D, T xf3 th V, Gerg x151 D, V xf6 r xf6 s I, On xf3 di Z, G xf6 rbe A, et al. Characterization of the CDAA Diet-Induced Non-alcoholic Steatohepatitis Model: Sex-Specific Differences in Inflammation, Fibrosis, and Cholesterol Metabolism in Middle-Aged Mice. Front Physiol. 2021;12:609465 pubmed publisher
Barbu E, Mihaila A, Gan A, Ciortan L, Macarie R, Tucureanu M, et al. The Elevated Inflammatory Status of Neutrophils Is Related to In-Hospital Complications in Patients with Acute Coronary Syndrome and Has Important Prognosis Value for Diabetic Patients. Int J Mol Sci. 2024;25: pubmed publisher
Shad A, Rewell S, Macowan M, Gandasasmita N, Wang J, Chen K, et al. Modelling lung infection with Klebsiella pneumoniae after murine traumatic brain injury. J Neuroinflammation. 2024;21:122 pubmed publisher
Su Q, Su C, Zhang Y, Guo Y, Liu Y, Liu Y, et al. Adjudin protects blood-brain barrier integrity and attenuates neuroinflammation following intracerebral hemorrhage in mice. Int Immunopharmacol. 2024;132:111962 pubmed publisher
Abraham M, Goncalves C, McCallum P, Gupta V, Preston S, Huang F, et al. Tunable PhenoCycler imaging of the murine pre-clinical tumour microenvironments. Cell Biosci. 2024;14:19 pubmed publisher
Hutka B, V xe1 rallyay A, L xe1 szl xf3 S, T xf3 th A, Scheich B, Paku S, et al. A dual role of lysophosphatidic acid type 2 receptor (LPAR2) in nonsteroidal anti-inflammatory drug-induced mouse enteropathy. Acta Pharmacol Sin. 2024;45:339-353 pubmed publisher
Wilkening R, Langou xeb t Astri xe9 C, Severn M, Federle M, Horswill A. Identifying genetic determinants of Streptococcus pyogenes-host interactions in a murine intact skin infection model. Cell Rep. 2023;42:113332 pubmed publisher
Shi G, Liu L, Cao Y, Ma G, Zhu Y, Xu J, et al. Inhibition of neutrophil extracellular trap formation ameliorates neuroinflammation and neuronal apoptosis via STING-dependent IRE1α/ASK1/JNK signaling pathway in mice with traumatic brain injury. J Neuroinflammation. 2023;20:222 pubmed publisher
Cao L, Ma L, Zhao J, Wang X, Fang X, Li W, et al. An unexpected role of neutrophils in clearing apoptotic hepatocytes in vivo. elife. 2023;12: pubmed publisher
Zhang H, Wu D, Wang Y, Guo K, Spencer C, Ortoga L, et al. METTL3-mediated N6-methyladenosine exacerbates ferroptosis via m6A-IGF2BP2-dependent mitochondrial metabolic reprogramming in sepsis-induced acute lung injury. Clin Transl Med. 2023;13:e1389 pubmed publisher
Hernandez Pichardo A, Wilm B, Liptrott N, Murray P. Intravenous Administration of Human Umbilical Cord Mesenchymal Stromal Cells Leads to an Inflammatory Response in the Lung. Stem Cells Int. 2023;2023:7397819 pubmed publisher
Yang M, Zhou X, Pearce S, Yang Z, Chen Q, Niu K, et al. Causal Role for Neutrophil Elastase in Thoracic Aortic Dissection in Mice. Arterioscler Thromb Vasc Biol. 2023;43:1900-1920 pubmed publisher
Ma T, Tang Y, Wang T, Yang Y, Zhang Y, Wang R, et al. Chronic pulmonary bacterial infection facilitates breast cancer lung metastasis by recruiting tumor-promoting MHCIIhi neutrophils. Signal Transduct Target Ther. 2023;8:296 pubmed publisher
Wu H, Guo C, Liu Z, Cai J, Wang C, Yi H, et al. Neutrophils exacerbate acetaminophen-induced liver injury by producing cytotoxic interferon-γ. Int Immunopharmacol. 2023;123:110734 pubmed publisher
Le P, Pal Ghosh S, Menko A, Stepp M. Immune Cells Localize to Sites of Corneal Erosions in C57BL/6 Mice. Biomolecules. 2023;13: pubmed publisher
Perico L, Morigi M, Pezzotta A, Locatelli M, Imberti B, Corna D, et al. SARS-CoV-2 spike protein induces lung endothelial cell dysfunction and thrombo-inflammation depending on the C3a/C3a receptor signalling. Sci Rep. 2023;13:11392 pubmed publisher
Maceiras A, Silv xe9 rio D, Gon xe7 alves R, Cardoso M, Saraiva M. Infection with hypervirulent Mycobacterium tuberculosis triggers emergency myelopoiesis but not trained immunity. Front Immunol. 2023;14:1211404 pubmed publisher
Shiratori Aso S, Nakazawa D, Kudo T, Kanda M, Ueda Y, Watanabe Kusunoki K, et al. CD47 blockade ameliorates autoimmune vasculitis via efferocytosis of neutrophil extracellular traps. JCI Insight. 2023;8: pubmed publisher
Li C, Chen T, Liu J, Wang Y, Zhang C, Guo L, et al. FGF19-Induced Inflammatory CAF Promoted Neutrophil Extracellular Trap Formation in the Liver Metastasis of Colorectal Cancer. Adv Sci (Weinh). 2023;10:e2302613 pubmed publisher
Huerga Encabo H, Aramburu I, Garcia Albornoz M, Piganeau M, WOOD H, Song A, et al. Loss of TET2 in human hematopoietic stem cells alters the development and function of neutrophils. Cell Stem Cell. 2023;30:781-799.e9 pubmed publisher
Sung P, Sun C, Tao M, Hsieh S. Inhibition of SARS-CoV-2-mediated thromboinflammation by CLEC2.Fc. EMBO Mol Med. 2023;15:e16351 pubmed publisher
Cao Y, Shi M, Liu L, Zuo Y, Jia H, Min X, et al. Inhibition of neutrophil extracellular trap formation attenuates NLRP1-dependent neuronal pyroptosis via STING/IRE1α pathway after traumatic brain injury in mice. Front Immunol. 2023;14:1125759 pubmed publisher
Silva B, Gomes G, Veras F, Cambier S, Silva G, Quadros A, et al. C5aR1 signaling triggers lung immunopathology in COVID-19 through neutrophil extracellular traps. J Clin Invest. 2023;133: pubmed publisher
Boonpraman N, Yoon S, Kim C, Moon J, Yi S. NOX4 as a critical effector mediating neuroinflammatory cytokines, myeloperoxidase and osteopontin, specifically in astrocytes in the hippocampus in Parkinson's disease. Redox Biol. 2023;62:102698 pubmed publisher
Veras F, Gomes G, Silva B, Caetit xe9 D, Almeida C, Silva C, et al. Targeting neutrophils extracellular traps (NETs) reduces multiple organ injury in a COVID-19 mouse model. Respir Res. 2023;24:66 pubmed publisher
Peng X, Li Y, Zhao W, Yang S, Huang J, Chen Y, et al. Blockade of neutrophil extracellular traps ameliorates toluene diisocyanate-induced steroid-resistant asthma. Int Immunopharmacol. 2023;117:109719 pubmed publisher
Elrod J, Lenz M, Kiwit A, Armbrust L, Sch xf6 nfeld L, Reinshagen K, et al. Murine scald models characterize the role of neutrophils and neutrophil extracellular traps in severe burns. Front Immunol. 2023;14:1113948 pubmed publisher
Sivaraman K, Wrenger S, Liu B, Schaudien D, Hesse C, Gomez Mariano G, et al. Mice inflammatory responses to inhaled aerosolized LPS: effects of various forms of human alpha1-antitrypsin. J Leukoc Biol. 2023;113:58-70 pubmed publisher
Liu T, Gammon S, Yang P, Ma W, Wang J, Piwnica Worms D. Inhibition of myeloperoxidase enhances immune checkpoint therapy for melanoma. J Immunother Cancer. 2023;11: pubmed publisher
Lee M, Kim H, Lee S, Lee J. Curcumin Ameliorates Particulate Matter-Induced Pulmonary Injury through Bimodal Regulation of Macrophage Inflammation via NF-κB and Nrf2. Int J Mol Sci. 2023;24: pubmed publisher
James B, Weigel C, Green C, Brown R, Palladino E, Tharakan A, et al. Neutrophilia in severe asthma is reduced in Ormdl3 overexpressing mice. FASEB J. 2023;37:e22799 pubmed publisher
Kucsera D, T xf3 th V, Sayour N, Kov xe1 cs T, Gergely T, Ruppert M, et al. IL-1β neutralization prevents diastolic dysfunction development, but lacks hepatoprotective effect in an aged mouse model of NASH. Sci Rep. 2023;13:356 pubmed publisher
Zarban A, Chaudhry H, Maselli D, Kodji X, de Sousa Valente J, Joachim J, et al. Enhancing Techniques for Determining Inflammatory Edema Formation and Neutrophil Accumulation in Murine Skin. JID Innov. 2023;3:100154 pubmed publisher
Wang K, Liao Y, Li X, Wang R, Zeng Z, Cheng M, et al. Inhibition of neutrophil elastase prevents cigarette smoke exposure-induced formation of neutrophil extracellular traps and improves lung function in a mouse model of chronic obstructive pulmonary disease. Int Immunopharmacol. 2023;114:109537 pubmed publisher
Huang J, Tao H, Yancey P, Leuthner Z, May Zhang L, Jung J, et al. Scavenging dicarbonyls with 5'-O-pentyl-pyridoxamine increases HDL net cholesterol efflux capacity and attenuates atherosclerosis and insulin resistance. Mol Metab. 2023;67:101651 pubmed publisher
Zeller J, Cheung Tung Shing K, Nero T, McFadyen J, Krippner G, Bogner B, et al. A novel phosphocholine-mimetic inhibits a pro-inflammatory conformational change in C-reactive protein. EMBO Mol Med. 2023;15:e16236 pubmed publisher
Hou L, Voit R, Shibamura Fujiogi M, Koutsogiannaki S, Li Y, Chen Y, et al. CD11c regulates neutrophil maturation. Blood Adv. 2023;7:1312-1325 pubmed publisher
Carai P, Gonz xe1 lez L, Van Bruggen S, Spalart V, De Giorgio D, Geuens N, et al. Neutrophil inhibition improves acute inflammation in a murine model of viral myocarditis. Cardiovasc Res. 2023;118:3331-3345 pubmed publisher
Bounajem M, Denorme F, Rustad J, Campbell R, Grandhi R. Investigation of Neutrophil Extracellular Traps as Potential Mediators in the Pathogenesis of Non-Acute Subdural Hematomas: A Pilot Study. Diagnostics (Basel). 2022;12: pubmed publisher
Gjerstorff M, Traynor S, Gammelgaard O, Johansen S, Pedersen C, Ditzel H, et al. PDX Models: A Versatile Tool for Studying the Role of Myeloid-Derived Suppressor Cells in Breast Cancer. Cancers (Basel). 2022;14: pubmed publisher
Li Y, Jiang Q, Zhou X, Wu M, Chen J, Liu H, et al. A prospective marker for the prediction of postoperative deep venous thrombosis: Neutrophil extracellular traps. Front Cell Dev Biol. 2022;10:1071550 pubmed publisher
Aramburu I, Hoving D, Vernardis S, Tin M, Ioannou M, Temkin M, et al. Functional proteomic profiling links deficient DNA clearance with increased mortality in individuals with severe COVID-19 pneumonia. Immunity. 2022;55:2436-2453.e5 pubmed publisher
Pir G, Parray A, Ayadathil R, Pananchikkal S, Mir F, Muhammad I, et al. Platelet-Neutrophil Association in NETs-Rich Areas in the Retrieved AIS Patient Thrombi. Int J Mol Sci. 2022;23: pubmed publisher
Nakata K, Okazaki M, Sakaue T, Kinoshita R, Komoda Y, Shimizu D, et al. Functional Blockage of S100A8/A9 Ameliorates Ischemia-Reperfusion Injury in the Lung. Bioengineering (Basel). 2022;9: pubmed publisher
Yang J, Jin L, Kim H, Tian F, Yi Z, Bedi K, et al. KDM6A Loss Recruits Tumor-Associated Neutrophils and Promotes Neutrophil Extracellular Trap Formation in Pancreatic Cancer. Cancer Res. 2022;82:4247-4260 pubmed publisher
Chen H, Ho Y, Mezzadra R, Adrover J, Smolkin R, Zhu C, et al. Senescence rewires microenvironment sensing to facilitate anti-tumor immunity. Cancer Discov. 2022;: pubmed publisher
Hornigold K, Chu J, Chetwynd S, Machin P, Crossland L, Pantarelli C, et al. Age-related decline in the resistance of mice to bacterial infection and in LPS/TLR4 pathway-dependent neutrophil responses. Front Immunol. 2022;13:888415 pubmed publisher
Sung P, Peng Y, Yang S, Chiu C, Hsieh S. CLEC5A is critical in Pseudomonas aeruginosa-induced NET formation and acute lung injury. JCI Insight. 2022;7: pubmed publisher
Qu M, Chen Z, Qiu Z, Nan K, Wang Y, Shi Y, et al. Neutrophil extracellular traps-triggered impaired autophagic flux via METTL3 underlies sepsis-associated acute lung injury. Cell Death Discov. 2022;8:375 pubmed publisher
Li H, Qiao C, Zhao L, Jing Q, Xue D, Zhang Y. Epigallocatechin-3-gallate reduces neutrophil extracellular trap formation and tissue injury in severe acute pancreatitis. J Leukoc Biol. 2022;112:1427-1443 pubmed publisher
Yamamoto Y, Kadoya K, Terkawi M, Endo T, Konno K, Watanabe M, et al. Neutrophils delay repair process in Wallerian degeneration by releasing NETs outside the parenchyma. Life Sci Alliance. 2022;5: pubmed publisher
Gao F, Niu Y, Sun L, Li W, Xia H, Zhang Y, et al. Integrating network pharmacology and transcriptomic validation to investigate the efficacy and mechanism of Mufangji decoction preventing lung cancer. J Ethnopharmacol. 2022;298:115573 pubmed publisher
Janssen P, Tosi I, Hego A, Mar xe9 chal P, Marichal T, Radermecker C. Neutrophil Extracellular Traps Are Found in Bronchoalveolar Lavage Fluids of Horses With Severe Asthma and Correlate With Asthma Severity. Front Immunol. 2022;13:921077 pubmed publisher
Gupta A, Singh K, Fatima S, Ambreen S, Zimmermann S, Younis R, et al. Neutrophil Extracellular Traps Promote NLRP3 Inflammasome Activation and Glomerular Endothelial Dysfunction in Diabetic Kidney Disease. Nutrients. 2022;14: pubmed publisher
Chen W, Li B, Jia F, Li J, Huang H, Ni C, et al. High PANX1 Expression Leads to Neutrophil Recruitment and the Formation of a High Adenosine Immunosuppressive Tumor Microenvironment in Basal-like Breast Cancer. Cancers (Basel). 2022;14: pubmed publisher
Caporarello N, Lee J, Pham T, Jones D, Guan J, Link P, et al. Dysfunctional ERG signaling drives pulmonary vascular aging and persistent fibrosis. Nat Commun. 2022;13:4170 pubmed publisher
Sung P, Yang S, Peng Y, Sun C, Tao M, Hsieh S. CLEC5A and TLR2 are critical in SARS-CoV-2-induced NET formation and lung inflammation. J Biomed Sci. 2022;29:52 pubmed publisher
Le N, do Nascimento A, Schneberger D, Quach C, Zhang X, Aulakh G, et al. Deficiency of leukocyte-specific protein 1 (LSP1) alleviates asthmatic inflammation in a mouse model. Respir Res. 2022;23:165 pubmed publisher
Ye D, Yao J, Du W, Chen C, Yang Y, Yan K, et al. Neutrophil Extracellular Traps Mediate Acute Liver Failure in Regulation of miR-223/Neutrophil Elastase Signaling in Mice. Cell Mol Gastroenterol Hepatol. 2022;14:587-607 pubmed publisher
Arnholdt C, Kumaraswami K, G xf6 tz P, K xfc bler M, Lasch M, Deindl E. Depletion of γδ T Cells Leads to Reduced Angiogenesis and Increased Infiltration of Inflammatory M1-like Macrophages in Ischemic Muscle Tissue. Cells. 2022;11: pubmed publisher
M Ravindra V, Denorme F, D Alexander M, A Campbell R, Grandhi R. Endovascular mechanical thrombectomy in a child with COVID-19: Clot analysis reveals a novel pathway in the neuroinflammatory cascade resulting in large-vessel occlusion. Interv Neuroradiol. 2022;:15910199221094758 pubmed publisher
Jiang S, Chan C, Rovira Clav xe9 X, Chen H, Bai Y, Zhu B, et al. Combined protein and nucleic acid imaging reveals virus-dependent B cell and macrophage immunosuppression of tissue microenvironments. Immunity. 2022;55:1118-1134.e8 pubmed publisher
Denorme F, Portier I, Rustad J, Cody M, de Araujo C, Hoki C, et al. Neutrophil extracellular traps regulate ischemic stroke brain injury. J Clin Invest. 2022;132: pubmed publisher
Wang H, Tumes D, Hercus T, Yip K, Aloe C, Vlahos R, et al. Blocking the human common beta subunit of the GM-CSF, IL-5 and IL-3 receptors markedly reduces hyperinflammation in ARDS models. Cell Death Dis. 2022;13:137 pubmed publisher
Adrover J, Carrau L, Daßler Plenker J, Bram Y, Chandar V, Houghton S, et al. Disulfiram inhibits neutrophil extracellular trap formation and protects rodents from acute lung injury and SARS-CoV-2 infection. JCI Insight. 2022;7: pubmed publisher
Conrad C, Yildiz D, Cleary S, Margraf A, Cook L, Schlomann U, et al. ADAM8 signaling drives neutrophil migration and ARDS severity. JCI Insight. 2022;7: pubmed publisher
Staedtke V, Gray Bethke T, Liu G, Liapi E, Riggins G, Bai R. Neutrophil depletion enhanced the Clostridium novyi-NT therapy in mouse and rabbit tumor models. Neurooncol Adv. 2022;4:vdab184 pubmed publisher
Fujii Y, Monteiro N, Sah S, Javaheri H, Ueki Y, Fan Z, et al. Tlr2/4-Mediated Hyperinflammation Promotes Cherubism-Like Jawbone Expansion in Sh3bp2 (P416R) Knockin Mice. JBMR Plus. 2022;6:e10562 pubmed publisher
Stalder R, Brembilla N, Conrad C, Yawalkar N, Navarini A, Boehncke W, et al. Interleukin-17E, inducible nitric oxide synthase and arginase1 as new biomarkers in the identification of neutrophilic dermatoses. Clin Exp Dermatol. 2022;47:675-683 pubmed publisher
Namiguchi K, Sakaue T, Okazaki M, Kanno K, Komoda Y, Shikata F, et al. Unique Angiogenesis From Cardiac Arterioles During Pericardial Adhesion Formation. Front Cardiovasc Med. 2021;8:761591 pubmed publisher
Finelli R, Darbandi S, Pushparaj P, Henkel R, Ko E, Agarwal A. In Silico Sperm Proteome Analysis to Investigate DNA Repair Mechanisms in Varicocele Patients. Front Endocrinol (Lausanne). 2021;12:757592 pubmed publisher
Ngamsri K, Putri R, Jans C, Schindler K, Fuhr A, Zhang Y, et al. CXCR4 and CXCR7 Inhibition Ameliorates the Formation of Platelet-Neutrophil Complexes and Neutrophil Extracellular Traps through Adora2b Signaling. Int J Mol Sci. 2021;22: pubmed publisher
Ruhela D, Bhopale V, Kalakonda S, Thom S. Astrocyte-derived microparticles initiate a neuroinflammatory cycle due to carbon monoxide poisoning. Brain Behav Immun Health. 2021;18:100398 pubmed publisher
Cao W, Zhu M, Lee S, Lee S, Kim H, Park B, et al. Modulation of Cellular NAD+ Attenuates Cancer-Associated Hypercoagulability and Thrombosis via the Inhibition of Tissue Factor and Formation of Neutrophil Extracellular Traps. Int J Mol Sci. 2021;22: pubmed publisher
K xfc bler M, G xf6 tz P, Braumandl A, Beck S, Ishikawa Ankerhold H, Deindl E. Impact of C57BL/6J and SV-129 Mouse Strain Differences on Ischemia-Induced Postnatal Angiogenesis and the Associated Leukocyte Infiltration in a Murine Hindlimb Model of Ischemia. Int J Mol Sci. 2021;22: pubmed publisher
Lu Y, Huang Y, Li J, Huang J, Zhang L, Feng J, et al. Eosinophil extracellular traps drive asthma progression through neuro-immune signals. Nat Cell Biol. 2021;23:1060-1072 pubmed publisher
Harnischfeger F, O Connell F, Weiss M, Axelrod B, Hajnal A, Czaja K, et al. Sprague Dawley Rats Gaining Weight on a High Energy Diet Exhibit Damage to Taste Tissue Even after Return to a Healthy Diet. Nutrients. 2021;13: pubmed publisher
Tokuhiro T, Ishikawa A, Sato H, Takita S, Yoshikawa A, Anzai R, et al. Oxidized Phospholipids and Neutrophil Elastase Coordinately Play Critical Roles in NET Formation. Front Cell Dev Biol. 2021;9:718586 pubmed publisher
K xfc bler M, Beck S, Peffenk xf6 ver L, G xf6 tz P, Ishikawa Ankerhold H, Preissner K, et al. The Absence of Extracellular Cold-Inducible RNA-Binding Protein (eCIRP) Promotes Pro-Angiogenic Microenvironmental Conditions and Angiogenesis in Muscle Tissue Ischemia. Int J Mol Sci. 2021;22: pubmed publisher
Stackowicz J, Gaudenzio N, Serhan N, Conde E, Godon O, Marichal T, et al. Neutrophil-specific gain-of-function mutations in Nlrp3 promote development of cryopyrin-associated periodic syndrome. J Exp Med. 2021;218: pubmed publisher
Arandjelovic S, Perry J, Zhou M, Ceroi A, Smirnov I, Walk S, et al. ELMO1 signaling is a promoter of osteoclast function and bone loss. Nat Commun. 2021;12:4974 pubmed publisher
Kaiser R, Leunig A, Pekayvaz K, Popp O, Joppich M, Polewka V, et al. Self-sustaining IL-8 loops drive a prothrombotic neutrophil phenotype in severe COVID-19. JCI Insight. 2021;6: pubmed publisher
DORA D, Ferenczi S, Stavely R, Tóth V, Varga Z, Kovacs T, et al. Evidence of a Myenteric Plexus Barrier and Its Macrophage-Dependent Degradation During Murine Colitis: Implications in Enteric Neuroinflammation. Cell Mol Gastroenterol Hepatol. 2021;12:1617-1641 pubmed publisher
Deng J, Kang Y, Cheng C, Li X, Dai B, Katz M, et al. DDR1-induced neutrophil extracellular traps drive pancreatic cancer metastasis. JCI Insight. 2021;6: pubmed publisher
Vannitamby A, Saad M, Aloe C, Wang H, Kumar B, Vlahos R, et al. Aspirin-Triggered Resolvin D1 Reduces Proliferation and the Neutrophil to Lymphocyte Ratio in a Mutant KRAS-Driven Lung Adenocarcinoma Model. Cancers (Basel). 2021;13: pubmed publisher
Belforte N, Agostinone J, Alarcón Martínez L, Villafranca Baughman D, Dotigny F, Cueva Vargas J, et al. AMPK hyperactivation promotes dendrite retraction, synaptic loss, and neuronal dysfunction in glaucoma. Mol Neurodegener. 2021;16:43 pubmed publisher
Shibuya T, Kamiyama A, Sawada H, Kikuchi K, Maruyama M, Sawado R, et al. Immunoregulatory Monocyte Subset Promotes Metastasis Associated With Therapeutic Intervention for Primary Tumor. Front Immunol. 2021;12:663115 pubmed publisher
Götz P, Braumandl A, Kübler M, Kumaraswami K, Ishikawa Ankerhold H, Lasch M, et al. C3 Deficiency Leads to Increased Angiogenesis and Elevated Pro-Angiogenic Leukocyte Recruitment in Ischemic Muscle Tissue. Int J Mol Sci. 2021;22: pubmed publisher
Surolia R, Li F, Wang Z, Kashyap M, Srivastava R, Traylor A, et al. NETosis in the pathogenesis of acute lung injury following cutaneous chemical burns. JCI Insight. 2021;6: pubmed publisher
Kübler M, Beck S, Fischer S, Götz P, Kumaraswami K, Ishikawa Ankerhold H, et al. Absence of Cold-Inducible RNA-Binding Protein (CIRP) Promotes Angiogenesis and Regeneration of Ischemic Tissue by Inducing M2-Like Macrophage Polarization. Biomedicines. 2021;9: pubmed publisher
Klemke L, De Oliveira T, Witt D, Winkler N, Bohnenberger H, Bucala R, et al. Hsp90-stabilized MIF supports tumor progression via macrophage recruitment and angiogenesis in colorectal cancer. Cell Death Dis. 2021;12:155 pubmed publisher
Mehling R, Schwenck J, Lemberg C, Trautwein C, Zizmare L, Kramer D, et al. Immunomodulatory role of reactive oxygen species and nitrogen species during T cell-driven neutrophil-enriched acute and chronic cutaneous delayed-type hypersensitivity reactions. Theranostics. 2021;11:470-490 pubmed publisher
Thomas M, Major E, Benedek A, Horvath I, Mathe D, Bergmann R, et al. Suppression of Metastatic Melanoma Growth in Lung by Modulated Electro-Hyperthermia Monitored by a Minimally Invasive Heat Stress Testing Approach in Mice. Cancers (Basel). 2020;12: pubmed publisher
Lasch M, Kumaraswami K, Nasiscionyte S, Kircher S, van den Heuvel D, Meister S, et al. RNase A Treatment Interferes With Leukocyte Recruitment, Neutrophil Extracellular Trap Formation, and Angiogenesis in Ischemic Muscle Tissue. Front Physiol. 2020;11:576736 pubmed publisher
Kerber E, Padberg C, Koll N, Schuetzhold V, Fandrey J, Winning S. The Importance of Hypoxia-Inducible Factors (HIF-1 and HIF-2) for the Pathophysiology of Inflammatory Bowel Disease. Int J Mol Sci. 2020;21: pubmed publisher
Moreira Teixeira L, Stimpson P, Stavropoulos E, Hadebe S, Chakravarty P, Ioannou M, et al. Type I IFN exacerbates disease in tuberculosis-susceptible mice by inducing neutrophil-mediated lung inflammation and NETosis. Nat Commun. 2020;11:5566 pubmed publisher
Essig F, Kollikowski A, Pham M, Solymosi L, Stoll G, Haeusler K, et al. Immunohistological Analysis of Neutrophils and Neutrophil Extracellular Traps in Human Thrombemboli Causing Acute Ischemic Stroke. Int J Mol Sci. 2020;21: pubmed publisher
Ouwendijk W, van den Ham H, Delany M, van Kampen J, van Nierop G, Mehraban T, et al. Alveolar barrier disruption in varicella pneumonia is associated with neutrophil extracellular trap formation. JCI Insight. 2020;5: pubmed publisher
Peek V, Neumann E, Inoue T, Koenig S, Pflieger F, Gerstberger R, et al. Age-Dependent Changes of Adipokine and Cytokine Secretion From Rat Adipose Tissue by Endogenous and Exogenous Toll-Like Receptor Agonists. Front Immunol. 2020;11:1800 pubmed publisher
Radermecker C, Detrembleur N, Guiot J, Cavalier E, Henket M, D Emal C, et al. Neutrophil extracellular traps infiltrate the lung airway, interstitial, and vascular compartments in severe COVID-19. J Exp Med. 2020;217: pubmed publisher
Taylor S, Whitfield M, Barratt J, Didangelos A. The Metalloproteinase ADAMTS5 Is Expressed by Interstitial Inflammatory Cells in IgA Nephropathy and Is Proteolytically Active on the Kidney Matrix. J Immunol. 2020;205:2243-2254 pubmed publisher
Lin E, Lai H, Cheng Y, Leong K, Cheng L, Chou Y, et al. Neutrophil Extracellular Traps Impair Intestinal Barrier Function during Experimental Colitis. Biomedicines. 2020;8: pubmed publisher
Nicolai L, Leunig A, Brambs S, Kaiser R, Weinberger T, Weigand M, et al. Immunothrombotic Dysregulation in COVID-19 Pneumonia Is Associated With Respiratory Failure and Coagulopathy. Circulation. 2020;142:1176-1189 pubmed publisher
Vaibhav K, Braun M, Alverson K, Khodadadi H, Kutiyanawalla A, Ward A, et al. Neutrophil extracellular traps exacerbate neurological deficits after traumatic brain injury. Sci Adv. 2020;6:eaax8847 pubmed publisher
Tsourouktsoglou T, Warnatsch A, Ioannou M, Hoving D, Wang Q, Papayannopoulos V. Histones, DNA, and Citrullination Promote Neutrophil Extracellular Trap Inflammation by Regulating the Localization and Activation of TLR4. Cell Rep. 2020;31:107602 pubmed publisher
Somerville T, Biffi G, Da ler Plenker J, Hur S, He X, Vance K, et al. Squamous trans-differentiation of pancreatic cancer cells promotes stromal inflammation. elife. 2020;9: pubmed publisher
Chirivi R, van Rosmalen J, van der Linden M, Euler M, Schmets G, BOGATKEVICH G, et al. Therapeutic ACPA inhibits NET formation: a potential therapy for neutrophil-mediated inflammatory diseases. Cell Mol Immunol. 2021;18:1528-1544 pubmed publisher
Fonseca K, Maceiras A, Matos R, Simões Costa L, Sousa J, Cá B, et al. Deficiency in the glycosyltransferase Gcnt1 increases susceptibility to tuberculosis through a mechanism involving neutrophils. Mucosal Immunol. 2020;13:836-848 pubmed publisher
Zhang T, Yin C, Boyd D, Quarato G, Ingram J, Shubina M, et al. Influenza Virus Z-RNAs Induce ZBP1-Mediated Necroptosis. Cell. 2020;180:1115-1129.e13 pubmed publisher
Kovacs B, Tillmann J, Freund L, Nimmerjahn F, Sadik C, Bieber K, et al. Fcγ Receptor IIB Controls Skin Inflammation in an Active Model of Epidermolysis Bullosa Acquisita. Front Immunol. 2019;10:3012 pubmed publisher
Adrover J, Aroca Crevillén A, Crainiciuc G, Ostos F, Rojas Vega Y, Rubio Ponce A, et al. Programmed 'disarming' of the neutrophil proteome reduces the magnitude of inflammation. Nat Immunol. 2020;21:135-144 pubmed publisher
Takesue S, Ohuchida K, Shinkawa T, Otsubo Y, Matsumoto S, Sagara A, et al. Neutrophil extracellular traps promote liver micrometastasis in pancreatic ductal adenocarcinoma via the activation of cancer‑associated fibroblasts. Int J Oncol. 2020;56:596-605 pubmed publisher
Endig J, Unrau L, Sprezyna P, Rading S, Karsak M, Goltz D, et al. Acute Liver Injury after CCl4 Administration is Independent of Smad7 Expression in Myeloid Cells. Int J Mol Sci. 2019;20: pubmed publisher
Lorscheid S, Muller A, Löffler J, Resch C, Bucher P, Kurschus F, et al. Keratinocyte-derived IκBζ drives psoriasis and associated systemic inflammation. JCI Insight. 2019;4: pubmed publisher
Radermecker C, Sabatel C, Vanwinge C, Ruscitti C, Maréchal P, Perin F, et al. Locally instructed CXCR4hi neutrophils trigger environment-driven allergic asthma through the release of neutrophil extracellular traps. Nat Immunol. 2019;20:1444-1455 pubmed publisher
Ghosh S, Padmanabhan A, Vaidya T, Watson A, Bhutto I, Hose S, et al. Neutrophils homing into the retina trigger pathology in early age-related macular degeneration. Commun Biol. 2019;2:348 pubmed publisher
Chan S, Ng M, Zhao H, Ng G, De Foo C, Wong P, et al. Early and Sustained Increases in Leukotriene B4 Levels Are Associated with Poor Clinical Outcome in Ischemic Stroke Patients. Neurotherapeutics. 2020;17:282-293 pubmed publisher
Zhang J, Harada Y, Hayashi Y. A TLR-CXCL1 pathway in DRG neurons induces neutrophil accumulation in the DRG and mechanical allodynia in EAE mice. Sci Rep. 2019;9:12003 pubmed publisher
Bitschar K, Sauer B, Focken J, Dehmer H, Moos S, Konnerth M, et al. Lugdunin amplifies innate immune responses in the skin in synergy with host- and microbiota-derived factors. Nat Commun. 2019;10:2730 pubmed publisher
Tong M, Potter J, Mor G, Abrahams V. Lipopolysaccharide-Stimulated Human Fetal Membranes Induce Neutrophil Activation and Release of Vital Neutrophil Extracellular Traps. J Immunol. 2019;: pubmed publisher
Sung P, Huang T, Hsieh S. Extracellular vesicles from CLEC2-activated platelets enhance dengue virus-induced lethality via CLEC5A/TLR2. Nat Commun. 2019;10:2402 pubmed publisher
Harada Y, Zhang J, Imari K, Yamasaki R, Ni J, Wu Z, et al. Cathepsin E in neutrophils contributes to the generation of neuropathic pain in experimental autoimmune encephalomyelitis. Pain. 2019;: pubmed publisher
Cheng D, Talib J, Stanley C, Rashid I, Michaëlsson E, Lindstedt E, et al. Inhibition of MPO (Myeloperoxidase) Attenuates Endothelial Dysfunction in Mouse Models of Vascular Inflammation and Atherosclerosis. Arterioscler Thromb Vasc Biol. 2019;39:1448-1457 pubmed publisher
Szczerba B, Castro Giner F, Vetter M, Krol I, Gkountela S, Landin J, et al. Neutrophils escort circulating tumour cells to enable cell cycle progression. Nature. 2019;566:553-557 pubmed publisher
Simon N, Antignani A, Hewitt S, Gadina M, Alewine C, Fitzgerald D. Tofacitinib enhances delivery of antibody-based therapeutics to tumor cells through modulation of inflammatory cells. JCI Insight. 2019;4: pubmed publisher
Zeng Z, Zhang Y, Liang X, Wang F, Zhao J, Xu Z, et al. Qingnao dripping pills mediate immune-inflammatory response and MAPK signaling pathway after acute ischemic stroke in rats. J Pharmacol Sci. 2019;139:143-150 pubmed publisher
Dmitrieva Posocco O, Dzutsev A, Posocco D, Hou V, Yuan W, Thovarai V, et al. Cell-Type-Specific Responses to Interleukin-1 Control Microbial Invasion and Tumor-Elicited Inflammation in Colorectal Cancer. Immunity. 2019;50:166-180.e7 pubmed publisher
Weckbach L, Grabmaier U, Uhl A, Gess S, Boehm F, Zehrer A, et al. Midkine drives cardiac inflammation by promoting neutrophil trafficking and NETosis in myocarditis. J Exp Med. 2019;216:350-368 pubmed publisher
Rojas Quintero J, Wang X, Tipper J, Burkett P, Zuniga J, Ashtekar A, et al. Matrix metalloproteinase-9 deficiency protects mice from severe influenza A viral infection. JCI Insight. 2018;3: pubmed publisher
Wong R, Lénárt N, Hill L, Toms L, Coutts G, Martinecz B, et al. Interleukin-1 mediates ischaemic brain injury via distinct actions on endothelial cells and cholinergic neurons. Brain Behav Immun. 2019;76:126-138 pubmed publisher
Offenbacher S, Jiao Y, Kim S, Marchesan J, Moss K, Jing L, et al. GWAS for Interleukin-1β levels in gingival crevicular fluid identifies IL37 variants in periodontal inflammation. Nat Commun. 2018;9:3686 pubmed publisher
Cheng Z, Wang L, Qu M, Liang H, Li W, Li Y, et al. Mesenchymal stem cells attenuate blood-brain barrier leakage after cerebral ischemia in mice. J Neuroinflammation. 2018;15:135 pubmed publisher
Perrault D, Bramos A, Xu X, Shi S, Wong A. Local Administration of Interleukin-1 Receptor Antagonist Improves Diabetic Wound Healing. Ann Plast Surg. 2018;80:S317-S321 pubmed publisher
Lörchner H, Widera C, Hou Y, Elsasser A, Warnecke H, Giannitsis E, et al. Reg3β is associated with cardiac inflammation and provides prognostic information in patients with acute coronary syndrome. Int J Cardiol. 2018;258:7-13 pubmed publisher
Cheon S, Kim J, Kam E, Ho C, Kim E, Chung S, et al. Cell-penetrating interactomic inhibition of nuclear factor-kappa B in a mouse model of postoperative cognitive dysfunction. Sci Rep. 2017;7:13482 pubmed publisher
Johnson M, Pang B, Gardner D, Niknam Benia S, Soundarajan V, Bramos A, et al. Topical Fibronectin Improves Wound Healing of Irradiated Skin. Sci Rep. 2017;7:3876 pubmed publisher
Dougher C, Buffone A, Nemeth M, Nasirikenari M, Irons E, Bogner P, et al. The blood-borne sialyltransferase ST6Gal-1 is a negative systemic regulator of granulopoiesis. J Leukoc Biol. 2017;102:507-516 pubmed publisher
Toussaint M, Jackson D, Swieboda D, Guedán A, Tsourouktsoglou T, Ching Y, et al. Host DNA released by NETosis promotes rhinovirus-induced type-2 allergic asthma exacerbation. Nat Med. 2017;23:681-691 pubmed publisher
Silva F, Oliveira E, Gouveia A, Brugiolo A, Alves C, Correa J, et al. Obesity promotes prolonged ovalbumin-induced airway inflammation modulating T helper type 1 (Th1), Th2 and Th17 immune responses in BALB/c mice. Clin Exp Immunol. 2017;189:47-59 pubmed publisher
Erpenbeck L, Chowdhury C, Zsengellér Z, Gallant M, Burke S, Cifuni S, et al. PAD4 Deficiency Decreases Inflammation and Susceptibility to Pregnancy Loss in a Mouse Model. Biol Reprod. 2016;95:132 pubmed publisher
Floyd M, Winn M, Cullen C, Sil P, Chassaing B, Yoo D, et al. Swimming Motility Mediates the Formation of Neutrophil Extracellular Traps Induced by Flagellated Pseudomonas aeruginosa. PLoS Pathog. 2016;12:e1005987 pubmed publisher
Jellbauer S, Perez Lopez A, Behnsen J, Gao N, Nguyen T, Murphy C, et al. Beneficial Effects of Sodium Phenylbutyrate Administration during Infection with Salmonella enterica Serovar Typhimurium. Infect Immun. 2016;84:2639-52 pubmed publisher
Hopke A, Nicke N, Hidu E, Degani G, Popolo L, Wheeler R. Neutrophil Attack Triggers Extracellular Trap-Dependent Candida Cell Wall Remodeling and Altered Immune Recognition. PLoS Pathog. 2016;12:e1005644 pubmed publisher
product information
brand :
R&D Systems
master code :
AF3667
SKU :
AF3667
product name :
Human/Mouse Myeloperoxidase/MPO Antibody
unit size :
100 ug (also 25 ug)
seo description :
The Human/Mouse Myeloperoxidase/MPO Antibody from R&D Systems is a goat polyclonal antibody to Myeloperoxidase/MPO. This antibody reacts with hamster,human,mouse,primate,rat,transgenic mouse,xenograft. The Human/Mouse Myeloperoxidase/MPO Antibody has been validated for the following applications: Immunohistochemistry,Immunocytochemistry,Western Blot,IHC/IF,Flow Cytometry,ELISA Capture,ELISA Development,Functional Assay,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry/ Immunofluorescence,Simple Western,Dual RNAscope ISH-IHC Compatible.
target :
Myeloperoxidase/MPO
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. See Certificate of Analysis for details. *Small pack size (-SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Polyclonal
concentration :
LYOPH
conjugate :
Unconjugated
dilution :
Western Blot 0.5 ug/mL, Simple Western 5 ug/mL, Immunohistochemistry 1-15 ug/mL, Immunocytochemistry 5-15 ug/mL, Dual RNAscope ISH-IHC 5-15 ug/mL
host :
Goat
immunogen :
Mouse myeloma cell line NS0-derived recombinant mouse MPO, Met16-Thr718, Accession # P11247
isotype :
IgG
purity :
Antigen Affinity-purified
species :
Hamster,Human,Mouse,Primate,Rat,Transgenic Mouse,Xenograft
specificity :
Detects human and mouse Myeloperoxidase/MPO in Western blots. In direct ELISAs, less than 1% cross-reactivity with recombinant mouse EPPO is observed.
gene symbol :
MPO
top caption :
Detection of Human/Mouse Myeloperoxidase/MPO antibody by Western Blot.
accessionNumbers :
P11247
applications :
Simple Western,Dual RNAscope ISH-IHC Compatible,ELISA Development,IHC/IF,Flow Cytometry,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry,Functional Assay,Immunocytochemistry/ Immunofluorescence,ELISA Capture
USD :
509 USD
alt names :
EC 1.11.1, EC 1.11.1.7, MPO, myeloperoxidase
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.