product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human Snail Antibody
catalog :
AF3639
quantity :
100 ug (also 25 ug)
price :
519 USD
clonality :
polyclonal
host :
domestic goat
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, chromatin immunoprecipitation, immunohistochemistry - paraffin section
more info or order :
R&D Systems product webpage
citations: 22
Reference
Despin Guitard E, Rosa V, Plunder S, Mathiah N, Van Schoor K, Nehme E, et al. Non-apical mitoses contribute to cell delamination during mouse gastrulation. Nat Commun. 2024;15:7364 pubmed publisher
Twomey J, Zhang B. Exploring the Role of Hypoxia-Inducible Carbonic Anhydrase IX (CAIX) in Circulating Tumor Cells (CTCs) of Breast Cancer. Biomedicines. 2023;11: pubmed publisher
Nakashima Y, Miyagi Shiohira C, Saitoh I, Watanabe M, Matsushita M, Tsukahara M, et al. Induced hepatic stem cells are suitable for human hepatocyte production. iScience. 2022;25:105052 pubmed publisher
Simunovic M, Siggia E, Brivanlou A. In vitro attachment and symmetry breaking of a human embryo model assembled from primed embryonic stem cells. Cell Stem Cell. 2022;29:962-972.e4 pubmed publisher
Huang M, Yang F, Zhang D, Lin M, Duan H, El Mayta R, et al. Endothelial plasticity drives aberrant vascularization and impedes cardiac repair after myocardial infarction. Nat Cardiovasc Res. 2022;1:372-388 pubmed publisher
Morgani S, Su J, Nichols J, Massague J, Hadjantonakis A. The transcription factor Rreb1 regulates epithelial architecture, invasiveness, and vasculogenesis in early mouse embryos. elife. 2021;10: pubmed publisher
Li L, Liu Q, Shang T, Song W, Xu D, Allen T, et al. Aberrant Activation of Notch1 Signaling in Glomerular Endothelium Induces Albuminuria. Circ Res. 2021;128:602-618 pubmed publisher
Tian X, Yu H, Li D, Jin G, Dai S, Gong P, et al. The miR-5694/AF9/Snail Axis Provides Metastatic Advantages and a Therapeutic Target in Basal-like Breast Cancer. Mol Ther. 2021;29:1239-1257 pubmed publisher
Battistelli C, Garbo S, Riccioni V, Montaldo C, Santangelo L, Vandelli A, et al. Design and Functional Validation of a Mutant Variant of the LncRNA HOTAIR to Counteract Snail Function in Epithelial-to-Mesenchymal Transition. Cancer Res. 2021;81:103-113 pubmed publisher
Zanfi E, Fantini S, Lotti R, Bertesi M, Marconi A, Grande A, et al. Wnt/CTNNB1 Signal Transduction Pathway Inhibits the Expression of ZFP36 in Squamous Cell Carcinoma, by Inducing Transcriptional Repressors SNAI1, SLUG and TWIST. Int J Mol Sci. 2020;21: pubmed publisher
Skrzypek K, Kot M, Konieczny P, Nieszporek A, Kusienicka A, Lasota M, et al. SNAIL Promotes Metastatic Behavior of Rhabdomyosarcoma by Increasing EZRIN and AKT Expression and Regulating MicroRNA Networks. Cancers (Basel). 2020;12: pubmed publisher
Boles N, Fernandes M, Swigut T, Srinivasan R, Schiff L, Rada Iglesias A, et al. Epigenomic and Transcriptomic Changes During Human RPE EMT in a Stem Cell Model of Epiretinal Membrane Pathogenesis and Prevention by Nicotinamide. Stem Cell Reports. 2020;14:631-647 pubmed publisher
Hamidi S, Nakaya Y, Nagai H, Alev C, Kasukawa T, Chhabra S, et al. Mesenchymal-epithelial transition regulates initiation of pluripotency exit before gastrulation. Development. 2020;147: pubmed publisher
Zhang R, Liu J, Zhang W, Hua L, Qian L, Zhou S. EphA5 knockdown enhances the invasion and migration ability of esophageal squamous cell carcinoma via epithelial-mesenchymal transition through activating Wnt/β-catenin pathway. Cancer Cell Int. 2020;20:20 pubmed publisher
Fukuura K, Inoue Y, Miyajima C, Watanabe S, Tokugawa M, Morishita D, et al. The ubiquitin-specific protease USP17 prevents cellular senescence by stabilizing the methyltransferase SET8 and transcriptionally repressing p21. J Biol Chem. 2019;294:16429-16439 pubmed publisher
Rademaker G, Costanza B, Anania S, Agirman F, Maloujahmoum N, Di Valentin E, et al. Myoferlin Contributes to the Metastatic Phenotype of Pancreatic Cancer Cells by Enhancing Their Migratory Capacity through the Control of Oxidative Phosphorylation. Cancers (Basel). 2019;11: pubmed publisher
Oh J, Lee J, Im W, Chun S. Ginsenoside Rk1 Induces Apoptosis in Neuroblastoma Cells Through Loss of Mitochondrial Membrane Potential and Activation of Caspases. Int J Mol Sci. 2019;20: pubmed publisher
Kurihara Shimomura M, Sasahira T, Shimomura H, Nakashima C, Kirita T. The Oncogenic Activity of miR-29b-1-5p Induces the Epithelial-Mesenchymal Transition in Oral Squamous Cell Carcinoma. J Clin Med. 2019;8: pubmed publisher
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Chen Y, Wang D, Wu Y, Su D, Zhou T, Gai R, et al. MDM2 promotes epithelial-mesenchymal transition and metastasis of ovarian cancer SKOV3 cells. Br J Cancer. 2017;117:1192-1201 pubmed publisher
Rokavec M, Kaller M, Horst D, Hermeking H. Pan-cancer EMT-signature identifies RBM47 down-regulation during colorectal cancer progression. Sci Rep. 2017;7:4687 pubmed publisher
product information
brand :
R&D Systems
master code :
AF3639
SKU :
AF3639
product name :
Human Snail Antibody
unit size :
100 ug (also 25 ug)
seo description :
The Human Snail Antibody from R&D Systems is a goat polyclonal antibody to Snail. This antibody reacts with human,mouse. The Human Snail Antibody has been validated for the following applications: Immunohistochemistry,Immunoprecipitation,Western Blot,Immunohistochemistry-Paraffin,Immunofluorescence,Chromatin Immunoprecipitation (ChIP),Immunocytochemistry,Intracellular Staining by Flow Cytometry.
target :
Snail
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Polyclonal
concentration :
LYOPH
conjugate :
Unconjugated
dilution :
Western Blot 0.5 ug/mL, Intracellular Staining by Flow Cytometry 0.25 ug/10^6 cells, Chromatin Immunoprecipitation (ChIP) 5 ug/5 x 10^6 cells, Immunocytochemistry 5-15 ug/mL
host :
Goat
immunogen :
E. coli -derived recombinant human Snail, Pro2-Arg264, Accession # O95863
isotype :
IgG
purity :
Antigen Affinity-purified
species :
Human,Mouse
specificity :
Detects human Snail in direct ELISAs and Western blots.
gene symbol :
SNAI1
top caption :
Detection of Human Snail antibody by Western Blot.
accessionNumbers :
O95863
applications :
Intracellular Staining by Flow Cytometry,Immunohistochemistry,Immunoprecipitation,Western Blot,Immunohistochemistry-Paraffin,Immunofluorescence,Chromatin Immunoprecipitation (ChIP),Immunocytochemistry
USD :
519 USD
alt names :
dJ710H13.1, Protein sna, Protein snail homolog 1, SLUGH2, SNA, SNAH, SNAI1, SNAIL, snail 1 homolog, snail 1 zinc finger protein, snail family zinc finger 1, snail homolog 1, SNAIL1, zinc finger protein SNAI1
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.