product summary
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company name :
R&D Systems
product type :
antibody
product name :
Mouse KLF4 Antibody
catalog :
AF3158
quantity :
100 ug (also 25 ug)
price :
489 USD
clonality :
polyclonal
host :
domestic goat
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, chromatin immunoprecipitation, immunohistochemistry - paraffin section
more info or order :
citations: 53
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 8j
Sünderhauf A, Hicken M, Schlichting H, Skibbe K, Ragab M, Raschdorf A, et al. Loss of Mucosal p32/gC1qR/HABP1 Triggers Energy Deficiency and Impairs Goblet Cell Differentiation in Ulcerative Colitis. Cell Mol Gastroenterol Hepatol. 2021;12:229-250 pubmed publisher
Borrelli C, Roberts M, Eletto D, Hussherr M, Fazilaty H, Valenta T, et al. In vivo interaction screening reveals liver-derived constraints to metastasis. Nature. 2024;632:411-418 pubmed publisher
Chakraborty S, Singh A, Wang L, Wang X, Sanborn M, Ye Z, et al. Trained immunity of alveolar macrophages enhances injury resolution via KLF4-MERTK-mediated efferocytosis. J Exp Med. 2023;220: pubmed publisher
Banerjee K, Lin Y, Gahn J, Cordero J, Gupta P, Mohamed I, et al. SMAD4 maintains the fluid shear stress set point to protect against arterial-venous malformations. J Clin Invest. 2023;133: pubmed publisher
Sato S, Hishida T, Kinouchi K, Hatanaka F, Li Y, Nguyen Q, et al. The circadian clock CRY1 regulates pluripotent stem cell identity and somatic cell reprogramming. Cell Rep. 2023;42:112590 pubmed publisher
Brahma S, Henikoff S. RNA Polymerase II, the BAF remodeler and transcription factors synergize to evict nucleosomes. bioRxiv. 2023;: pubmed publisher
Yang X, Wu S, Gao R, Wang R, Wang Y, Dong Z, et al. Release of STK24/25 suppression on MEKK3 signaling in endothelial cells confers cerebral cavernous malformation. JCI Insight. 2023;8: pubmed publisher
Maeda H, Yao H, Go H, Huntington K, De Paepe M, Dennery P. Involvement of miRNA-34a regulated Krüppel-like factor 4 expression in hyperoxia-induced senescence in lung epithelial cells. Respir Res. 2022;23:340 pubmed publisher
Bi J, Wang W, Zhang M, Zhang B, Liu M, Su G, et al. KLF4 inhibits early neural differentiation of ESCs by coordinating specific 3D chromatin structure. Nucleic Acids Res. 2022;50:12235-50 pubmed publisher
Dai Z, Li J, Li Y, Wang R, Yan H, Xiong Z, et al. Role of pericytes in the development of cerebral cavernous malformations. iScience. 2022;25:105642 pubmed publisher
Yu S, Zhou C, He J, Yao Z, Huang X, Rong B, et al. BMP4 drives primed to naïve transition through PGC-like state. Nat Commun. 2022;13:2756 pubmed publisher
Guo L, Bian J, Davis A, Liu P, Kempton H, Zhang X, et al. Multiplexed genome regulation in vivo with hyper-efficient Cas12a. Nat Cell Biol. 2022;24:590-600 pubmed publisher
Zuo Z, Yang G, Wang H, Liu S, Zhang Y, Cai Y, et al. Klf4 methylated by Prmt1 restrains the commitment of primitive endoderm. Nucleic Acids Res. 2022;50:2005-2018 pubmed publisher
Langkabel J, Horne A, Bonaguro L, Holsten L, Hesse T, Knaus A, et al. Induction of Rosette-to-Lumen stage embryoids using reprogramming paradigms in ESCs. Nat Commun. 2021;12:7322 pubmed publisher
Festuccia N, Owens N, Chervova A, Dubois A, Navarro P. The combined action of Esrrb and Nr5a2 is essential for murine naïve pluripotency. Development. 2021;148: pubmed publisher
Liu Y, Yamane J, Tanaka A, Fujibuchi W, Yamashita J. AMPK activation reverts mouse epiblast stem cells to naive state. iScience. 2021;24:102783 pubmed publisher
Huang S, Kuri P, Aubert Y, Brewster M, Li N, Farrelly O, et al. Lgr6 marks epidermal stem cells with a nerve-dependent role in wound re-epithelialization. Cell Stem Cell. 2021;28:1582-1596.e6 pubmed publisher
Bayerl J, Ayyash M, Shani T, Manor Y, Gafni O, Massarwa R, et al. Principles of signaling pathway modulation for enhancing human naive pluripotency induction. Cell Stem Cell. 2021;: pubmed publisher
Ren A, Snellings D, Su Y, Hong C, Castro M, Tang A, et al. PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism. Nature. 2021;594:271-276 pubmed publisher
Avsec x, Weilert M, Shrikumar A, Krueger S, Alexandari A, Dalal K, et al. Base-resolution models of transcription-factor binding reveal soft motif syntax. Nat Genet. 2021;53:354-366 pubmed publisher
Lu Y, Brommer B, Tian X, Krishnan A, Meer M, Wang C, et al. Reprogramming to recover youthful epigenetic information and restore vision. Nature. 2020;588:124-129 pubmed publisher
Orzechowska E, Katano T, Bialkowska A, Yang V. Interplay among p21Waf1/Cip1, MUSASHI-1 and Krüppel-like factor 4 in activation of Bmi1-CreER reserve intestinal stem cells after gamma radiation-induced injury. Sci Rep. 2020;10:18300 pubmed publisher
Bustos F, Segarra Fas A, Nardocci G, Cassidy A, Antico O, Davidson L, et al. Functional Diversification of SRSF Protein Kinase to Control Ubiquitin-Dependent Neurodevelopmental Signaling. Dev Cell. 2020;55:629-647.e7 pubmed publisher
Hayashi Y, Asuzu D, Bardsley M, Gajdos G, Kvasha S, Linden D, et al. Wnt-induced, TRP53-mediated Cell Cycle Arrest of Precursors Underlies Interstitial Cell of Cajal Depletion During Aging. Cell Mol Gastroenterol Hepatol. 2021;11:117-145 pubmed publisher
Li Y, Song Y, Xu W, Li Q, Wang X, Li K, et al. R-loops coordinate with SOX2 in regulating reprogramming to pluripotency. Sci Adv. 2020;6:eaba0777 pubmed publisher
Ito S, Nada S, Yamazaki D, Kimura T, Kajiwara K, Miki H, et al. p18/Lamtor1-mTORC1 Signaling Controls Development of Mucin-producing Goblet Cells in the Intestine. Cell Struct Funct. 2020;45:93-105 pubmed publisher
He B, Johansson Percival A, Backhouse J, Li J, Lee G, Hamzah J, et al. Remodeling of Metastatic Vasculature Reduces Lung Colonization and Sensitizes Overt Metastases to Immunotherapy. Cell Rep. 2020;30:714-724.e5 pubmed publisher
Satoh T, Mellett M, Meier Schiesser B, Fenini G, Otsuka A, Beer H, et al. IL-36γ drives skin toxicity induced by EGFR/MEK inhibition and commensal Cutibacterium acnes. J Clin Invest. 2019;: pubmed publisher
Yang Y, Cha B, Motawe Z, Srinivasan R, Scallan J. VE-Cadherin Is Required for Lymphatic Valve Formation and Maintenance. Cell Rep. 2019;28:2397-2412.e4 pubmed publisher
Stuart H, Stirparo G, Lohoff T, Bates L, Kinoshita M, Lim C, et al. Distinct Molecular Trajectories Converge to Induce Naive Pluripotency. Cell Stem Cell. 2019;25:388-406.e8 pubmed publisher
Diéguez Hurtado R, Kato K, Giaimo B, Nieminen Kelhä M, Arf H, Ferrante F, et al. Loss of the transcription factor RBPJ induces disease-promoting properties in brain pericytes. Nat Commun. 2019;10:2817 pubmed publisher
Malinverno M, Maderna C, Abu Taha A, Corada M, Orsenigo F, Valentino M, et al. Endothelial cell clonal expansion in the development of cerebral cavernous malformations. Nat Commun. 2019;10:2761 pubmed publisher
Luo Z, Qing X, Benda C, Huang Z, Zhang M, Huang Y, et al. Nuclear-cytoplasmic shuttling of class IIa histone deacetylases regulates somatic cell reprogramming. Cell Regen (Lond). 2019;8:21-29 pubmed publisher
Samudyata -, Amaral P, Engström P, Robson S, Nielsen M, Kouzarides T, et al. Interaction of Sox2 with RNA binding proteins in mouse embryonic stem cells. Exp Cell Res. 2019;: pubmed publisher
Kalkan T, Bornelöv S, Mulas C, Diamanti E, Lohoff T, Ralser M, et al. Complementary Activity of ETV5, RBPJ, and TCF3 Drives Formative Transition from Naive Pluripotency. Cell Stem Cell. 2019;24:785-801.e7 pubmed publisher
Sastre Perona A, Hoang Phou S, Leitner M, Okuniewska M, Meehan S, Schober M. De Novo PITX1 Expression Controls Bi-Stable Transcriptional Circuits to Govern Self-Renewal and Differentiation in Squamous Cell Carcinoma. Cell Stem Cell. 2019;24:390-404.e8 pubmed publisher
Zeng Z, Xia L, Fan X, Ostriker A, Yarovinsky T, Su M, et al. Platelet-derived miR-223 promotes a phenotypic switch in arterial injury repair. J Clin Invest. 2019;129:1372-1386 pubmed publisher
Xiong X, Schober M, Tassone E, Khodadadi Jamayran A, Sastre Perona A, Zhou H, et al. KLF4, A Gene Regulating Prostate Stem Cell Homeostasis, Is a Barrier to Malignant Progression and Predictor of Good Prognosis in Prostate Cancer. Cell Rep. 2018;25:3006-3020.e7 pubmed publisher
Sardina J, Collombet S, Tian T, Gomez A, Di Stefano B, Berenguer C, et al. Transcription Factors Drive Tet2-Mediated Enhancer Demethylation to Reprogram Cell Fate. Cell Stem Cell. 2018;23:727-741.e9 pubmed publisher
Chuang H, Tsai C, Hsueh C, Tan T. GLK-IKKβ signaling induces dimerization and translocation of the AhR-RORγt complex in IL-17A induction and autoimmune disease. Sci Adv. 2018;4:eaat5401 pubmed publisher
Fajka Boja R, Marton A, Tóth A, Blazso P, Tubak V, Bálint B, et al. Increased insulin-like growth factor 1 production by polyploid adipose stem cells promotes growth of breast cancer cells. BMC Cancer. 2018;18:872 pubmed publisher
Estrada C, Paladugu P, Guo Y, Pace J, Revelo M, Salant D, et al. Krüppel-like factor 4 is a negative regulator of STAT3-induced glomerular epithelial cell proliferation. JCI Insight. 2018;3: pubmed publisher
Adachi K, Kopp W, Wu G, Heising S, Greber B, Stehling M, et al. Esrrb Unlocks Silenced Enhancers for Reprogramming to Naive Pluripotency. Cell Stem Cell. 2018;23:266-275.e6 pubmed publisher
Bustos F, Segarra Fas A, Chaugule V, Brandenburg L, Branigan E, Toth R, et al. RNF12 X-Linked Intellectual Disability Mutations Disrupt E3 Ligase Activity and Neural Differentiation. Cell Rep. 2018;23:1599-1611 pubmed publisher
Sheikh A, Saddouk F, Ntokou A, Mazurek R, Greif D. Cell Autonomous and Non-cell Autonomous Regulation of SMC Progenitors in Pulmonary Hypertension. Cell Rep. 2018;23:1152-1165 pubmed publisher
Antognelli C, Trapani E, Delle Monache S, Perrelli A, Fornelli C, Retta F, et al. Data in support of sustained upregulation of adaptive redox homeostasis mechanisms caused by KRIT1 loss-of-function. Data Brief. 2018;16:929-938 pubmed publisher
Kim J, Park D, Bae H, Park D, Kim D, Lee C, et al. Impaired angiopoietin/Tie2 signaling compromises Schlemm's canal integrity and induces glaucoma. J Clin Invest. 2017;127:3877-3896 pubmed publisher
Sainz de la Maza D, Moratilla A, Aparicio V, Lorca C, Alcaina Y, Martín D, et al. Metabolic Reprogramming, Autophagy, and Reactive Oxygen Species Are Necessary for Primordial Germ Cell Reprogramming into Pluripotency. Oxid Med Cell Longev. 2017;2017:4745252 pubmed publisher
Xu M, Horrell J, Snitow M, Cui J, Gochnauer H, Syrett C, et al. WNT10A mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and KLF4-mediated differentiation. Nat Commun. 2017;8:15397 pubmed publisher
Wang P, Lan C, Xiong S, Zhao X, Shan Y, Hu R, et al. HIF1α regulates single differentiated glioma cell dedifferentiation to stem-like cell phenotypes with high tumorigenic potential under hypoxia. Oncotarget. 2017;8:28074-28092 pubmed publisher
Wang P, Wan W, Xiong S, Feng H, Wu N. Cancer stem-like cells can be induced through dedifferentiation under hypoxic conditions in glioma, hepatoma and lung cancer. Cell Death Discov. 2017;3:16105 pubmed publisher
Gao S, Hou X, Jiang Y, Xu Z, Cai T, Chen J, et al. Integrated analysis of hematopoietic differentiation outcomes and molecular characterization reveals unbiased differentiation capacity and minor transcriptional memory in HPC/HSC-iPSCs. Stem Cell Res Ther. 2017;8:13 pubmed publisher
Ye S, Zhang D, Cheng F, Wilson D, Mackay J, He K, et al. Wnt/β-catenin and LIF-Stat3 signaling pathways converge on Sp5 to promote mouse embryonic stem cell self-renewal. J Cell Sci. 2016;129:269-76 pubmed publisher
product information
brand :
R&D Systems
master code :
AF3158
SKU :
AF3158
product name :
Mouse KLF4 Antibody
unit size :
100 ug (also 25 ug)
seo description :
The Mouse KLF4 Antibody from R&D Systems is a goat polyclonal antibody to KLF4. This antibody reacts with human,mouse,transgenic mouse. The Mouse KLF4 Antibody has been validated for the following applications: Western Blot,Immunohistochemistry,Immunocytochemistry,Co-Immunoprecipitation,Flow Cytometry,Immunoprecipitation,Immunohistochemistry-Paraffin,Chromatin Immunoprecipitation (ChIP),Immunocytochemistry/ Immunofluorescence.
target :
KLF4
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Polyclonal
concentration :
LYOPH
conjugate :
Unconjugated
dilution :
Western Blot 0.1 ug/mL, Immunohistochemistry 1-25 ug/mL, Chromatin Immunoprecipitation (ChIP) 5 ug/5 x 10^6 cells, Immunocytochemistry 5-15 ug/mL
host :
Goat
immunogen :
E. coli -derived recombinant mouse KLF4, Ala11-Phe483, Accession # Q60793
isotype :
IgG
purity :
Antigen Affinity-purified
species :
Human,Mouse,Transgenic Mouse
specificity :
Detects mouse KLF4 in direct ELISAs and Western blots.
gene symbol :
KLF4
top caption :
Detection of KLF4-regulated Genes antibody by Chromatin Immunoprecipitation.
accessionNumbers :
Q60793
applications :
Co-Immunoprecipitation,Flow Cytometry,Immunohistochemistry,Immunoprecipitation,Western Blot,Immunohistochemistry-Paraffin,Chromatin Immunoprecipitation (ChIP),Immunocytochemistry,Immunocytochemistry/ Immunofluorescence
USD :
489 USD
alt names :
Epithelial zinc finger protein EZF, EZF, EZFendothelial Kruppel-like zinc finger protein, GKLFKrueppel-like factor 4, Gut-enriched krueppel-like factor, Kruppel-like factor 4 (gut)
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.