product summary
Loading...
company name :
R&D Systems
product type :
antibody
product name :
Human Sortilin Antibody
catalog :
AF3154
quantity :
100 ug (also 25 ug)
price :
519 USD
clonality :
polyclonal
host :
domestic goat
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, neutralization, flow cytometry, immunohistochemistry - paraffin section
more info or order :
R&D Systems product webpage
citations: 6
Reference
Ullgren A, xd6 ijerstedt L, Olofsson J, Bergstr xf6 m S, Remnest xe5 l J, van Swieten J, et al. Altered plasma protein profiles in genetic FTD - a GENFI study. Mol Neurodegener. 2023;18:85 pubmed publisher
Jiang J, Yang C, Ai J, Zhang Q, Cai X, Tu T, et al. Intraneuronal sortilin aggregation relative to granulovacuolar degeneration, tau pathogenesis and sorfra plaque formation in human hippocampal formation. Front Aging Neurosci. 2022;14:926904 pubmed publisher
Xu S, Zhang Q, Zhang Q, Wan L, Jiang J, Tu T, et al. Regional and Cellular Mapping of Sortilin Immunoreactivity in Adult Human Brain. Front Neuroanat. 2019;13:31 pubmed publisher
Fleitas C, Piñol Ripoll G, Marfull P, Rocandio D, Ferrer I, Rampon C, et al. proBDNF is modified by advanced glycation end products in Alzheimer's disease and causes neuronal apoptosis by inducing p75 neurotrophin receptor processing. Mol Brain. 2018;11:68 pubmed publisher
Hagita S, Rogers M, Pham T, Wen J, Mlynarchik A, Aikawa M, et al. Transcriptional control of intestinal cholesterol absorption, adipose energy expenditure and lipid handling by Sortilin. Sci Rep. 2018;8:9006 pubmed publisher
Zhou F, Jiang J, Griffith C, Patrylo P, Cai H, Chu Y, et al. Lack of human-like extracellular sortilin neuropathology in transgenic Alzheimer's disease model mice and macaques. Alzheimers Res Ther. 2018;10:40 pubmed publisher
product information
brand :
R&D Systems
master code :
AF3154
SKU :
AF3154
product name :
Human Sortilin Antibody
unit size :
100 ug (also 25 ug)
seo description :
The Human Sortilin Antibody from R&D Systems is a goat polyclonal antibody to Sortilin. This antibody reacts with human,mouse,primate,transgenic mouse. The Human Sortilin Antibody has been validated for the following applications: Immunohistochemistry,Bioassay,Western Blot,Neutralization,Immunohistochemistry-Paraffin,Immunocytochemistry,Flow Cytometry,Simple Western,Blockade of Receptor-ligand Interaction.
target :
Sortilin
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Polyclonal
concentration :
LYOPH
conjugate :
Unconjugated
dilution :
Western Blot 2 ug/mL, Simple Western 10 ug/mL, Flow Cytometry 0.25 ug/10^6 cells, Immunohistochemistry 5-15 ug/mL, Blockade of Receptor-ligand Interaction
host :
Goat
immunogen :
Mouse myeloma cell line NS0-derived recombinant human Sortilin, Ser78-Asn755, Accession # Q99523
isotype :
IgG
purity :
Antigen Affinity-purified
species :
Human,Mouse,Primate,Transgenic Mouse
specificity :
Detects human and mouse Sortilin in direct ELISAs and Western blots.
gene symbol :
SORT1
endotoxin note :
<0.10 EU per 1 ╡g of the antibody by the LAL method.
top caption :
Detection of Human Sortilin antibody by Western Blot.
accessionNumbers :
Q99523
applications :
Flow Cytometry,Simple Western,Blockade of Receptor-ligand Interaction,Bioassay,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Neutralization,Immunocytochemistry
USD :
519 USD
alt names :
100 kDa NT receptor, Glycoprotein 95, Gp95, Gp95LDLCQ6, Neurotensin receptor 3, NT3NTR3, Ntr3, SORT1, sortilin, sortilin 1
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.