Human EphB4 Antibody | R&D Systems AF3038 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human EphB4 Antibody

catalog :

AF3038

quantity :

100 ug (also 25 ug)

price :

489 USD

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - frozen section

more info or order :

R&D Systems product webpage

citations: 8

Reference
Chen D, Wiggins D, Sevick E, Davis M, King P. An EPHB4-RASA1 signaling complex inhibits shear stress-induced Ras-MAPK activation in lymphatic endothelial cells to promote the development of lymphatic vessel valves. bioRxiv. 2023;: pubmed publisher
Schwickert A, Henrich W, Vogel M, Melchior K, Ehrlich L, Ochs M, et al. Placenta Percreta Presents with Neoangiogenesis of Arteries with Von Willebrand Factor-Negative Endothelium. Reprod Sci. 2022;29:1136-1144 pubmed publisher
Martin Almedina S, Ogmen K, Sackey E, Grigoriadis D, Karapouliou C, Nadarajah N, et al. Janus-faced EPHB4-associated disorders: novel pathogenic variants and unreported intrafamilial overlapping phenotypes. Genet Med. 2021;23:1315-1324 pubmed publisher
Donato C, Kunz L, Castro Giner F, Paasinen Sohns A, Strittmatter K, Szczerba B, et al. Hypoxia Triggers the Intravasation of Clustered Circulating Tumor Cells. Cell Rep. 2020;32:108105 pubmed publisher
Frye M, Stritt S, Ortsäter H, Hernandez Vasquez M, Kaakinen M, Vicente A, et al. EphrinB2-EphB4 signalling provides Rho-mediated homeostatic control of lymphatic endothelial cell junction integrity. elife. 2020;9: pubmed publisher
de Muijnck C, van Gorkom Y, van Duijvenvoorde M, Eghtesadi M, Dekker Ensink G, Bhairosingh S, et al. Evaluation of EphB4 as Target for Image-Guided Surgery of Breast Cancer. Pharmaceuticals (Basel). 2020;13: pubmed publisher
Fuggetta M, Bordignon V, Cottarelli A, Macchi B, Frezza C, Cordiali Fei P, et al. Downregulation of proinflammatory cytokines in HTLV-1-infected T cells by Resveratrol. J Exp Clin Cancer Res. 2016;35:118 pubmed publisher
Martin Almedina S, Martínez Corral I, Holdhus R, Vicente A, Fotiou E, Lin S, et al. EPHB4 kinase-inactivating mutations cause autosomal dominant lymphatic-related hydrops fetalis. J Clin Invest. 2016;126:3080-8 pubmed publisher

product information

master code :

AF3038

SKU :

AF3038

product name :

Human EphB4 Antibody

unit size :

100 ug (also 25 ug)

description :

The Human EphB4 Antibody from R&D Systems is a goat polyclonal antibody to EphB4. This antibody reacts with human,mouse. The Human EphB4 Antibody has been validated for the following applications: Immunohistochemistry,Immunoprecipitation,Western Blot,Immunohistochemistry-Frozen,Immunocytochemistry,Flow Cytometry,Simple Western,CyTOF-ready,Knockout Validated.

target :

EphB4

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Polyclonal

concentration :

LYOPH

conjugate :

Unconjugated

host :

Goat

immunogen :

Mouse myeloma cell line NS0-derived recombinant human EphB4, Leu16-Ala539, Accession # P54760

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Human,Mouse

specificity :

Detects human EphB4 in direct ELISAs and Western blots. In direct ELISAs, less than 10% cross-reactivity with recombinant mouse (rm) EphB4 is observed and less than 1% cross-reactivity with recombinant human (rh) EphA4, rhEphA3, rhEphB2, and rhEphB3 is observed.

gene symbol :

EPHB4

Antibody validation :

Knockout/Knockdown

top caption :

Detection of Human EphB4 antibody by Western Blot.

accessionNumbers :

P54760

applications :

Immunoprecipitation,Western Blot,Immunohistochemistry,Immunohistochemistry-Frozen,Immunocytochemistry,Flow Cytometry,Simple Western,CyTOF-ready,Knockout Validated

USD :

489 USD

alt names :

EC 2.7.10, EC 2.7.10.1, EPH receptor B4, EphB4, ephrin type-B receptor 4, hepatoma transmembrane kinase, Htk, HTKephrin receptor EphB4, Mdk2, Myk1, soluble EPHB4 variant 1, soluble EPHB4 variant 2, soluble EPHB4 variant 3, Tyro11, Tyrosine-protein kinase receptor HTK, Tyrosine-protein kinase TYRO11

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage