Human/Mouse/Rat HIF-2 alpha /EPAS1 Antibody | R&D Systems AF2997 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human/Mouse/Rat HIF-2 alpha /EPAS1 Antibody

catalog :

AF2997

quantity :

100 ug (also 25 ug)

price :

479 USD

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

R&D Systems product webpage

citations: 18

Reference
Seidel L, Thudium J, Smith C, Sapehia V, Sommer N, Wujak M, et al. Death-associated protein kinase 1 prevents hypoxia-induced metabolic shift and pulmonary arterial smooth muscle cell proliferation in PAH. Cell Signal. 2025;127:111527 pubmed publisher
Wulf S, Mizko L, Herrmann K, S xe1 nchez Carbonell M, Urbach A, Lemke C, et al. Targeted Disruption of the MORG1 Gene in Mice Causes Embryonic Resorption in Early Phase of Development. Biomolecules. 2023;13: pubmed publisher
Mello A, Ngodup T, Lee Y, Donahue K, Li J, Rao A, et al. Hypoxia promotes an inflammatory phenotype of fibroblasts in pancreatic cancer. Oncogenesis. 2022;11:56 pubmed publisher
Jatho A, Zieseniss A, Brechtel Curth K, Guo J, Böker K, Salinas G, et al. The HIFα-Stabilizing Drug Roxadustat Increases the Number of Renal Epo-Producing Sca-1+ Cells. Cells. 2022;11: pubmed publisher
Protze J, Naas S, Kr xfc ger R, St xf6 hr C, Kraus A, Grampp S, et al. The renal cancer risk allele at 14q24.2 activates a novel hypoxia-inducible transcription factor-binding enhancer of DPF3 expression. J Biol Chem. 2022;298:101699 pubmed publisher
Wujak M, Veith C, Wu C, Wilke T, Kanbagli Z, Novoyatleva T, et al. Adenylate Kinase 4-A Key Regulator of Proliferation and Metabolic Shift in Human Pulmonary Arterial Smooth Muscle Cells via Akt and HIF-1α Signaling Pathways. Int J Mol Sci. 2021;22: pubmed publisher
Kaluz S, Zhang Q, Kuranaga Y, Yang H, Osuka S, Bhattacharya D, et al. Targeting HIF-activated collagen prolyl 4-hydroxylase expression disrupts collagen deposition and blocks primary and metastatic uveal melanoma growth. Oncogene. 2021;40:5182-5191 pubmed publisher
Veliça P, Cunha P, Vojnovic N, Foskolou I, Bargiela D, Gojkovic M, et al. Modified Hypoxia-Inducible Factor Expression in CD8+ T Cells Increases Antitumor Efficacy. Cancer Immunol Res. 2021;9:401-414 pubmed publisher
Yang W, Yu T, Huang X, Bilotta A, Xu L, Lu Y, et al. Intestinal microbiota-derived short-chain fatty acids regulation of immune cell IL-22 production and gut immunity. Nat Commun. 2020;11:4457 pubmed publisher
Burrows N, Bashford Rogers R, Bhute V, Peñalver A, Ferdinand J, Stewart B, et al. Dynamic regulation of hypoxia-inducible factor-1α activity is essential for normal B cell development. Nat Immunol. 2020;21:1408-1420 pubmed publisher
Toriuchi K, Kakita H, Tamura T, Takeshita S, Yamada Y, Aoyama M. Prolonged astrocyte-derived erythropoietin expression attenuates neuronal damage under hypothermic conditions. J Neuroinflammation. 2020;17:141 pubmed publisher
Morin A, Goncalves J, Moog S, Castro Vega L, Job S, Buffet A, et al. TET-Mediated Hypermethylation Primes SDH-Deficient Cells for HIF2α-Driven Mesenchymal Transition. Cell Rep. 2020;30:4551-4566.e7 pubmed publisher
Wohlrab C, Kuiper C, Vissers M, Phillips E, Robinson B, Dachs G. Ascorbate modulates the hypoxic pathway by increasing intracellular activity of the HIF hydroxylases in renal cell carcinoma cells. Hypoxia (Auckl). 2019;7:17-31 pubmed publisher
Zhang P, Cao L, Zhou R, Yang X, Wu M. The lncRNA Neat1 promotes activation of inflammasomes in macrophages. Nat Commun. 2019;10:1495 pubmed publisher
Dao D, Anez Bustillos L, Jabbouri S, Pan A, Kishikawa H, Mitchell P, et al. A paradoxical method to enhance compensatory lung growth: Utilizing a VEGF inhibitor. PLoS ONE. 2018;13:e0208579 pubmed publisher
Schwartz A, Das N, Ramakrishnan S, Jain C, Jurkovic M, Wu J, et al. Hepatic hepcidin/intestinal HIF-2α axis maintains iron absorption during iron deficiency and overload. J Clin Invest. 2019;129:336-348 pubmed publisher
Jiang B, Zhao W, Shi M, Zhang J, Chen A, Ma H, et al. IDH1 Arg-132 mutant promotes tumor formation through down-regulating p53. J Biol Chem. 2018;293:9747-9758 pubmed publisher
Kobayashi H, Liu Q, Binns T, Urrutia A, Davidoff O, Kapitsinou P, et al. Distinct subpopulations of FOXD1 stroma-derived cells regulate renal erythropoietin. J Clin Invest. 2016;126:1926-38 pubmed publisher

product information

master code :

AF2997

SKU :

AF2997

product name :

Human/Mouse/Rat HIF-2 alpha /EPAS1 Antibody

unit size :

100 ug (also 25 ug)

description :

The Human/Mouse/Rat HIF-2 alpha /EPAS1 Antibody from R&D Systems is a goat polyclonal antibody to HIF-2 alpha/EPAS1. This antibody reacts with human,mouse,rat. The Human/Mouse/Rat HIF-2 alpha /EPAS1 Antibody has been validated for the following applications: Western Blot,ELISA Development,Immunohistochemistry,Immunohistochemistry-Paraffin,Immunocytochemistry.

target :

HIF-2 alpha/EPAS1

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Polyclonal

conjugate :

Unconjugated

host :

Goat

immunogen :

E. coli -derived recombinant mouse HIF-2 alpha /EPAS1, Ser542-Thr874, Accession # AAH57870

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Human,Mouse,Rat

specificity :

Detects human, mouse, and rat HIF-2 alpha /EPAS1 in Western blots.

gene symbol :

EPAS1

top caption :

HIF-2a/EPAS1 antibody in Human Prostate Cancer Tissue by Immunohistochemistry (IHC-P).

accessionNumbers :

AAH57870

applications :

Western Blot,ELISA Development,Immunohistochemistry,Immunohistochemistry-Paraffin,Immunocytochemistry

USD :

479 USD

alt names :

Basic-helix-loop-helix-PAS protein MOP2, BHLHE73, Class E basic helix-loop-helix protein 73, ECYT4, endothelial PAS domain protein 1, endothelial PAS domain-containing protein 1, EPAS1, EPAS-1, HIF 2A, HIF-1-alpha-like factor, HIF-1alpha-like factor, HIF2 alpha, HIF-2 alpha, HIF2A, hif2a angiogenesis, HIF-2-alpha, HIF2-alpha, HLF, hypoxia-inducible factor 2 alpha, Hypoxia-inducible factor 2-alpha, Member of PAS protein 2, MOP2, PAS domain-containing protein 2, PASD2

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage