Mouse Sortilin Antibody | R&D Systems AF2934 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Mouse Sortilin Antibody

catalog :

AF2934

quantity :

100 ug (also 25 ug)

price :

499 USD

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry

more info or order :

R&D Systems product webpage

citations: 10

Reference
Overby M, Serrano Rodriguez A, Dadras S, Christiansen A, Ozcelik G, Lichtenthaler S, et al. Neuron-specific gene NSG1 binds to and positively regulates sortilin ectodomain shedding via a metalloproteinase-dependent mechanism. J Biol Chem. 2023;299:105446 pubmed publisher
Richter E, Lohmann C, Dell accio F, Goettsch C, Bertrand J. Sortilin Is Upregulated in Osteoarthritis-Dependent Cartilage Calcification and Associated with Cellular Senescence. Int J Mol Sci. 2023;24: pubmed publisher
Jakobsen T, xd8 stergaard J, Kjolby M, Birch E, Bek T, Nykjaer A, et al. Sortilin Inhibition Protects Neurons From Degeneration in the Diabetic Retina. Invest Ophthalmol Vis Sci. 2023;64:8 pubmed publisher
Tóth A, Nielsen M. Sortilins in the blood-brain barrier: impact on barrier integrity. Neural Regen Res. 2023;18:549-550 pubmed publisher
Ulrichsen M, Gon xe7 alves N, Mohseni S, Hj xe6 resen S, Lisle T, Molgaard S, et al. Sortilin Modulates Schwann Cell Signaling and Remak Bundle Regeneration Following Nerve Injury. Front Cell Neurosci. 2022;16:856734 pubmed publisher
Asaro A, Sinha R, Bakun M, Kalnytska O, Carlo Spiewok A, Rubel T, et al. ApoE4 disrupts interaction of sortilin with fatty acid-binding protein 7 essential to promote lipid signaling. J Cell Sci. 2021;134: pubmed publisher
Zhou X, Tao L, Zhao M, Wu S, Obeng E, Wang D, et al. Wnt/β-catenin signaling regulates brain-derived neurotrophic factor release from spinal microglia to mediate HIV1 gp120-induced neuropathic pain. Mol Pain. 2020;16:1744806920922100 pubmed publisher
Richner M, Pallesen L, Ulrichsen M, Poulsen E, Holm T, Login H, et al. Sortilin gates neurotensin and BDNF signaling to control peripheral neuropathic pain. Sci Adv. 2019;5:eaav9946 pubmed publisher
Uchiyama K, Tomita M, Yano M, Chida J, Hara H, Das N, et al. Prions amplify through degradation of the VPS10P sorting receptor sortilin. PLoS Pathog. 2017;13:e1006470 pubmed publisher
Zhou X, Sun L, Bracko O, Choi J, Jia Y, Nana A, et al. Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations. Nat Commun. 2017;8:15277 pubmed publisher

product information

brand :

R&D Systems

master code :

AF2934

SKU :

AF2934

product name :

Mouse Sortilin Antibody

unit size :

100 ug (also 25 ug)

seo description :

The Mouse Sortilin Antibody from R&D Systems is a goat polyclonal antibody to Sortilin. This antibody reacts with human,mouse. The Mouse Sortilin Antibody has been validated for the following applications: Immunohistochemistry,Western Blot,In vivo assay,Immunocytochemistry,Simple Western,Blockade of Receptor-ligand Interaction.

target :

Sortilin

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Polyclonal

concentration :

LYOPH

conjugate :

Unconjugated

dilution :

Western Blot 1 ug/mL, Simple Western 10 ug/mL, Immunohistochemistry 1-15 ug/mL, Blockade of Receptor-ligand Interaction

host :

Goat

immunogen :

Mouse myeloma cell line NS0-derived recombinant mouse Sortilin, Gly76-Asn753, Accession # Q6PHU5

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Human,Mouse

specificity :

Detects mouse Sortilin in direct ELISAs and Western blots. In direct ELISAs and Western blots, approximately 30% cross-reactivity with recombinant human Sortilin is observed.

gene symbol :

SORT1

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

top caption :

Detection of Mouse Sortilin antibody by Western Blot.

accessionNumbers :

Q6PHU5

applications :

Simple Western,Blockade of Receptor-ligand Interaction,Immunohistochemistry,Western Blot,In vivo assay,Immunocytochemistry

USD :

499 USD

alt names :

100 kDa NT receptor, Glycoprotein 95, Gp95, Gp95LDLCQ6, Neurotensin receptor 3, NT3NTR3, Ntr3, SORT1, sortilin, sortilin 1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage