product summary
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company name :
R&D Systems
product type :
antibody
product name :
Mouse Alkaline Phosphatase/ALPL Antibody
catalog :
AF2910
quantity :
100 ug (also 25 ug)
price :
499 USD
clonality :
polyclonal
host :
domestic goat
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 36
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 7e
Yu S, Guo J, Sun Z, Lin C, Tao H, Zhang Q, et al. BMP2-dependent gene regulatory network analysis reveals Klf4 as a novel transcription factor of osteoblast differentiation. Cell Death Dis. 2021;12:197 pubmed publisher
Moskowitzova K, Naus A, Kycia I, Dang T, Shroff Y, Bletsas E, et al. Comparative Effects on Fetal Hematopoiesis and Placental Inflammation From Mesenchymal and Hematopoietic Stem Cells as Agents of Transamniotic Stem Cell Therapy (TRASCET) in a Syngeneic Model of Intrauterine Growth Restriction. J Pediatr Surg. 2024;59:1277-1281 pubmed publisher
Overeem A, Chang Y, Moustakas I, Roelse C, Hillenius S, Helm T, et al. Efficient and scalable generation of primordial germ cells in 2D culture using basement membrane extract overlay. Cell Rep Methods. 2023;3:100488 pubmed publisher
Yu Y, Rong K, Yao D, Zhang Q, Cao X, Rao B, et al. The structural pathology for hypophosphatasia caused by malfunctional tissue non-specific alkaline phosphatase. Nat Commun. 2023;14:4048 pubmed publisher
Sun L, Zhang X, Wu S, Liu Y, Guerrero Juarez C, Liu W, et al. Dynamic interplay between IL-1 and WNT pathways in regulating dermal adipocyte lineage cells during skin development and wound regeneration. Cell Rep. 2023;42:112647 pubmed publisher
Wang C, Zhao Q, Chen C, Li J, Zhang J, Qu S, et al. CD301b+ macrophage: the new booster for activating bone regeneration in periodontitis treatment. Int J Oral Sci. 2023;15:19 pubmed publisher
Doolittle M, Saul D, Kaur J, Rowsey J, Vos S, Pavelko K, et al. Multiparametric senescent cell phenotyping reveals CD24 osteolineage cells as targets of senolytic therapy in the aged murine skeleton. bioRxiv. 2023;: pubmed publisher
Awida Z, Hiram Bab S, Bachar A, Saed H, Zyc D, Gorodov A, et al. Erythropoietin Receptor (EPOR) Signaling in the Osteoclast Lineage Contributes to EPO-Induced Bone Loss in Mice. Int J Mol Sci. 2022;23: pubmed publisher
Puissant E, Gilis F, Tevel V, Vandeweerd J, Flamion B, Jadot M, et al. Hyaluronidase 1 deficiency decreases bone mineral density in mice. Sci Rep. 2022;12:10142 pubmed publisher
Lin S, Yin S, Shi J, Yang G, Wen X, Zhang W, et al. Orchestration of energy metabolism and osteogenesis by Mg2+ facilitates low-dose BMP-2-driven regeneration. Bioact Mater. 2022;18:116-127 pubmed publisher
Chen Y, Wang H, Yang Q, Zhao W, Chen Y, Ni Q, et al. Single-cell RNA landscape of the osteoimmunology microenvironment in periodontitis. Theranostics. 2022;12:1074-1096 pubmed publisher
Awida Z, Bachar A, Saed H, Gorodov A, Ben Califa N, Ibrahim M, et al. The Non-Erythropoietic EPO Analogue Cibinetide Inhibits Osteoclastogenesis In Vitro and Increases Bone Mineral Density in Mice. Int J Mol Sci. 2021;23: pubmed publisher
Chen L, Zhang M, Chen P, Xiong X, Liu P, Wang H, et al. The m6A demethylase FTO promotes the osteogenesis of mesenchymal stem cells by downregulating PPARG. Acta Pharmacol Sin. 2021;: pubmed publisher
Sun Y, Rahbani J, Jedrychowski M, Riley C, Vidoni S, Bogoslavski D, et al. Mitochondrial TNAP controls thermogenesis by hydrolysis of phosphocreatine. Nature. 2021;593:580-585 pubmed publisher
Droujinine I, Meyer A, Wang D, Udeshi N, Hu Y, Rocco D, et al. Proteomics of protein trafficking by in vivo tissue-specific labeling. Nat Commun. 2021;12:2382 pubmed publisher
Yang X, Zhou F, Yuan P, Dou G, Liu X, Liu S, et al. T cell-depleting nanoparticles ameliorate bone loss by reducing activated T cells and regulating the Treg/Th17 balance. Bioact Mater. 2021;6:3150-3163 pubmed publisher
Hu L, Liu J, Xue H, Panayi A, Xie X, Lin Z, et al. miRNA-92a-3p regulates osteoblast differentiation in patients with concomitant limb fractures and TBI via IBSP/PI3K-AKT inhibition. Mol Ther Nucleic Acids. 2021;23:1345-1359 pubmed publisher
Pajarinen J, Lin T, Nabeshima A, Sato T, Gibon E, Jämsen E, et al. Interleukin-4 repairs wear particle induced osteolysis by modulating macrophage polarization and bone turnover. J Biomed Mater Res A. 2021;109:1512-1520 pubmed publisher
Takeyari S, Kubota T, Ohata Y, Fujiwara M, Kitaoka T, Taga Y, et al. 4-Phenylbutyric acid enhances the mineralization of osteogenesis imperfecta iPSC-derived osteoblasts. J Biol Chem. 2021;296:100027 pubmed publisher
Zhang L, Qi M, Chen J, Zhao J, Li L, Hu J, et al. Impaired autophagy triggered by HDAC9 in mesenchymal stem cells accelerates bone mass loss. Stem Cell Res Ther. 2020;11:269 pubmed publisher
Qiu X, Liu J, Zheng C, Su Y, Bao L, Zhu B, et al. Exosomes released from educated mesenchymal stem cells accelerate cutaneous wound healing via promoting angiogenesis. Cell Prolif. 2020;53:e12830 pubmed publisher
Voicu G, Rebleanu D, Constantinescu C, Fuior E, Ciortan L, Droc I, et al. Nano-Polyplexes Mediated Transfection of Runx2-shRNA Mitigates the Osteodifferentiation of Human Valvular Interstitial Cells. Pharmaceutics. 2020;12: pubmed publisher
Casas Fraile L, Cornelis F, Costamagna D, Rico A, Duelen R, Sampaolesi M, et al. Frizzled related protein deficiency impairs muscle strength, gait and calpain 3 levels. Orphanet J Rare Dis. 2020;15:119 pubmed publisher
Chen M, Yang A, Yousef H, Lee D, Chen W, Schaum N, et al. Brain Endothelial Cells Are Exquisite Sensors of Age-Related Circulatory Cues. Cell Rep. 2020;30:4418-4432.e4 pubmed publisher
Engelbrecht E, Lévesque M, He L, Vanlandewijck M, Nitzsche A, Niazi H, et al. Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta. elife. 2020;9: pubmed publisher
Sun X, Wei B, Peng Z, Chen X, Fu Q, Wang C, et al. A polysaccharide from the dried rhizome of Drynaria fortunei (Kunze) J. Sm. prevents ovariectomized (OVX)-induced osteoporosis in rats. J Cell Mol Med. 2020;24:3692-3700 pubmed publisher
Wei Q, Wang B, Hu H, Xie C, Ling L, Gao J, et al. Icaritin promotes the osteogenesis of bone marrow mesenchymal stem cells via the regulation of sclerostin expression. Int J Mol Med. 2020;45:816-824 pubmed publisher
Yin L, Zhou Z, Shen M, Chen N, Jiang F, Wang S. The Human Amniotic Mesenchymal Stem Cells (hAMSCs) Improve the Implant Osseointegration and Bone Regeneration in Maxillary Sinus Floor Elevation in Rabbits. Stem Cells Int. 2019;2019:9845497 pubmed publisher
Kazi T, Niibe I, Nishikawa A, Matsuzaki T. Optimal stimulation toward the dermal papilla lineage can be promoted by combined use of osteogenic and adipogenic inducers. FEBS Open Bio. 2019;: pubmed publisher
Charoenphandhu N, Aeimlapa R, Sooksawanwit S, Thongbunchoo J, Teerapornpuntakit J, Svasti S, et al. Responses of primary osteoblasts and osteoclasts from hemizygous β-globin knockout thalassemic mice with elevated plasma glucose to 1,25-dihydroxyvitamin D3. Sci Rep. 2019;9:13963 pubmed publisher
Liu W, Zhang L, Xuan K, Hu C, Li L, Zhang Y, et al. Alkaline Phosphatase Controls Lineage Switching of Mesenchymal Stem Cells by Regulating the LRP6/GSK3β Complex in Hypophosphatasia. Theranostics. 2018;8:5575-5592 pubmed publisher
Carr M, Toma J, Johnston A, Steadman P, Yuzwa S, Mahmud N, et al. Mesenchymal Precursor Cells in Adult Nerves Contribute to Mammalian Tissue Repair and Regeneration. Cell Stem Cell. 2019;24:240-256.e9 pubmed publisher
Sterner R, Kremer K, Dudakovic A, Westendorf J, Van Wijnen A, Hedin K. Tissue-Nonspecific Alkaline Phosphatase Is Required for MC3T3 Osteoblast-Mediated Protection of Acute Myeloid Leukemia Cells from Apoptosis. J Immunol. 2018;201:1086-1096 pubmed publisher
Giovannelli G, Giacomazzi G, Grosemans H, Sampaolesi M. Morphological and functional analyses of skeletal muscles from an immunodeficient animal model of limb-girdle muscular dystrophy type 2E. Muscle Nerve. 2018;: pubmed publisher
Coutu D, Kokkaliaris K, Kunz L, Schroeder T. Multicolor quantitative confocal imaging cytometry. Nat Methods. 2018;15:39-46 pubmed publisher
Pillai I, Li S, Romay M, Lam L, Lu Y, Huang J, et al. Cardiac Fibroblasts Adopt Osteogenic Fates and Can Be Targeted to Attenuate Pathological Heart Calcification. Cell Stem Cell. 2017;20:218-232.e5 pubmed publisher
product information
master code :
AF2910
SKU :
AF2910
product name :
Mouse Alkaline Phosphatase/ALPL Antibody
unit size :
100 ug (also 25 ug)
description :
The Mouse Alkaline Phosphatase/ALPL Antibody from R&D Systems is a goat polyclonal antibody to Alkaline Phosphatase/ALPL. This antibody reacts with human,mouse,rat. The Mouse Alkaline Phosphatase/ALPL Antibody has been validated for the following applications: Immunohistochemistry,Western Blot,Immunocytochemistry,CyTof,Flow Cytometry,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunoprecipitation,CyTOF-ready.
target :
Alkaline Phosphatase/ALPL
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Polyclonal
concentration :
LYOPH
conjugate :
Unconjugated
host :
Goat
immunogen :
Mouse myeloma cell line NS0-derived recombinant mouse Alkaline Phosphatase/ALPL, Phe18-Gly503, Accession # P09242
isotype :
IgG
purity :
Antigen Affinity-purified
species :
Human,Mouse,Rat
specificity :
Detects mouse Alkaline Phosphatase/ALPL in direct ELISAs and Western blots.
gene symbol :
ALPL
top caption :
Detection of Mouse Alkaline Phosphatase/ALPL antibody by Western Blot.
accessionNumbers :
P09242
applications :
Western Blot,Immunohistochemistry,Immunocytochemistry,CyTof,Flow Cytometry,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunoprecipitation,CyTOF-ready
USD :
499 USD
alt names :
Akp2, Alkaline phosphatase liver/bone/kidney isozyme, alkaline phosphatase, liver/bone/kidney, alkaline phosphatase, tissue-nonspecific isozyme, alkaline phosphomonoesterase, APTNAP, AP-TNAP, EC 3.1.3.1, FLJ40094, FLJ93059, glycerophosphatase, HOPS, liver/bone/kidney-type alkaline phosphatase, MGC161443, tissue-nonspecific ALP, TNAP, TNSALP, TNSALPMGC167935
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.