Human/Rat HIF-2 alpha /EPAS1 Antibody | R&D Systems AF2886 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human/Rat HIF-2 alpha /EPAS1 Antibody

catalog :

AF2886

quantity :

100 ug (also 25 ug)

price :

469 USD

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human, rat

application :

western blot, chromatin immunoprecipitation

more info or order :

R&D Systems product webpage

citations: 9

Reference
Militaru I, Rus A, Munteanu C, Manica G, Petrescu S. New panel of biomarkers to discriminate between amelanotic and melanotic metastatic melanoma. Front Oncol. 2022;12:1061832 pubmed publisher
Ma X, Tan Z, Zhang Q, Ma K, Xiao J, Wang X, et al. VHL Ser65 mutations enhance HIF2α signaling and promote epithelial-mesenchymal transition of renal cancer cells. Cell Biosci. 2022;12:52 pubmed publisher
Uchenunu O, Zhdanov A, Hutton P, Jovanovic P, Wang Y, Andreev D, et al. Mitochondrial complex IV defects induce metabolic and signaling perturbations that expose potential vulnerabilities in HCT116 cells. FEBS Open Bio. 2022;12:959-982 pubmed publisher
Clees A, Stolp V, Häupl B, Fuhrmann D, Wempe F, Seibert M, et al. Identification of the Cysteine Protease Legumain as a Potential Chronic Hypoxia-Specific Multiple Myeloma Target Gene. Cells. 2022;11: pubmed publisher
Del Balzo U, Signore P, Walkinshaw G, Seeley T, Brenner M, Wang Q, et al. Nonclinical Characterization of the Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor Roxadustat, a Novel Treatment of Anemia of Chronic Kidney Disease. J Pharmacol Exp Ther. 2020;374:342-353 pubmed publisher
Ghosh M, Zhang D, Ollivierre H, Eckhaus M, Rouault T. Translational repression of HIF2? expression in mice with Chuvash polycythemia reverses polycythemia. J Clin Invest. 2018;128:1317-1325 pubmed publisher
Martín Aragón Baudel M, Rae M, Darlison M, Poole A, Fraser J. Preferential activation of HIF-2? adaptive signalling in neuronal-like cells in response to acute hypoxia. PLoS ONE. 2017;12:e0185664 pubmed publisher
Li X, Lu J, Kan Q, Li X, Fan Q, Li Y, et al. Metabolic reprogramming is associated with flavopiridol resistance in prostate cancer DU145 cells. Sci Rep. 2017;7:5081 pubmed publisher
Bigot P, Colli L, Machiela M, Jessop L, Myers T, Carrouget J, et al. Functional characterization of the 12p12.1 renal cancer-susceptibility locus implicates BHLHE41. Nat Commun. 2016;7:12098 pubmed publisher

product information

brand :

R&D Systems

master code :

AF2886

SKU :

AF2886

product name :

Human/Rat HIF-2 alpha /EPAS1 Antibody

unit size :

100 ug (also 25 ug)

seo description :

The Human/Rat HIF-2 alpha /EPAS1 Antibody from R&D Systems is a goat polyclonal antibody to HIF-2 alpha/EPAS1. This antibody reacts with human,rat. The Human/Rat HIF-2 alpha /EPAS1 Antibody has been validated for the following applications: Western Blot,Chromatin Immunoprecipitation (ChIP).

target :

HIF-2 alpha/EPAS1

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Polyclonal

concentration :

LYOPH

conjugate :

Unconjugated

dilution :

Western Blot 1 ug/mL, Chromatin Immunoprecipitation (ChIP) 5 ug/5 x 10^6 cells

host :

Goat

immunogen :

E. coli -derived recombinant human HIF-2 alpha /EPAS1, Ser543-Thr870, Accession # Q99814

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Human,Rat

specificity :

Detects human and rat HIF-2 alpha /EPAS1.

gene symbol :

EPAS1

top caption :

Detection of Human and Rat HIF-2a/EPAS1 antibody by Western Blot.

accessionNumbers :

Q99814

applications :

Western Blot,Chromatin Immunoprecipitation (ChIP)

USD :

469 USD

alt names :

Basic-helix-loop-helix-PAS protein MOP2, BHLHE73, Class E basic helix-loop-helix protein 73, ECYT4, endothelial PAS domain protein 1, endothelial PAS domain-containing protein 1, EPAS1, EPAS-1, HIF 2A, HIF-1-alpha-like factor, HIF-1alpha-like factor, HIF2 alpha, HIF-2 alpha, HIF2A, hif2a angiogenesis, HIF-2-alpha, HIF2-alpha, HLF, hypoxia-inducible factor 2 alpha, Hypoxia-inducible factor 2-alpha, Member of PAS protein 2, MOP2, PAS domain-containing protein 2, PASD2

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage