product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human SOX10 Antibody
catalog :
AF2864
quantity :
100 ug (also 25 ug)
price :
519 USD
clonality :
polyclonal
host :
domestic goat
conjugate :
nonconjugated
reactivity :
human, mouse, rat, chicken
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, FACS, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, proximity ligation assay, immunohistochemistry knockout validation
more info or order :
citations: 98
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry knockout validation; chicken; 1:200; loading ...; fig 3d
Gandhi S, Li Y, Tang W, Christensen J, Urrutia H, Vieceli F, et al. A single-plasmid approach for genome editing coupled with long-term lineage analysis in chick embryos. Development. 2021;148: pubmed publisher
  • immunohistochemistry; mouse; 1:200; loading ...; fig 6e
Lohraseb I, McCarthy P, Secker G, Marchant C, Wu J, Ali N, et al. Global ubiquitinome profiling identifies NEDD4 as a regulator of Profilin 1 and actin remodelling in neural crest cells. Nat Commun. 2022;13:2018 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:500; loading ...; fig 1p
Kaucka M, Szarowska B, Kavkova M, Kastriti M, Kameneva P, Schmidt I, et al. Nerve-associated Schwann cell precursors contribute extracutaneous melanocytes to the heart, inner ear, supraorbital locations and brain meninges. Cell Mol Life Sci. 2021;78:6033-6049 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:300; loading ...; fig 2b, 3a
Paredes I, Vieira J, Shah B, Ramunno C, Dyckow J, Adler H, et al. Oligodendrocyte precursor cell specification is regulated by bidirectional neural progenitor-endothelial cell crosstalk. Nat Neurosci. 2021;24:478-488 pubmed publisher
Verstraelen P, Van Remoortel S, De Loose N, Verboven R, Garcia Díaz Barriga G, Christmann A, et al. Serum Amyloid A3 Fuels a Feed-Forward Inflammatory Response to the Bacterial Amyloid Curli in the Enteric Nervous System. Cell Mol Gastroenterol Hepatol. 2024;18:89-104 pubmed publisher
Tsartsalis S, Sleven H, Fancy N, Wessely F, Smith A, Willumsen N, et al. A single nuclear transcriptomic characterisation of mechanisms responsible for impaired angiogenesis and blood-brain barrier function in Alzheimer's disease. Nat Commun. 2024;15:2243 pubmed publisher
Robinson B, Oster B, Robertson K, Kaltschmidt J. Loss of ASD-related molecule Cntnap2 affects colonic motility in mice. Front Neurosci. 2023;17:1287057 pubmed publisher
Guo R, Han D, Song X, Gao Y, Li Z, Li X, et al. Context-dependent regulation of Notch signaling in glial development and tumorigenesis. Sci Adv. 2023;9:eadi2167 pubmed publisher
Li J, Jaiswal M, Chien J, Kozlenkov A, Jung J, Zhou P, et al. Divergent single cell transcriptome and epigenome alterations in ALS and FTD patients with C9orf72 mutation. Nat Commun. 2023;14:5714 pubmed publisher
Frazel P, Labib D, Fisher T, Brosh R, Pirjanian N, Marchildon A, et al. Longitudinal scRNA-seq analysis in mouse and human informs optimization of rapid mouse astrocyte differentiation protocols. Nat Neurosci. 2023;26:1726-1738 pubmed publisher
Clayton B, Barbar L, Sapar M, Rusielewicz T, Kalpana K, Migliori B, et al. Patient iPSC models reveal glia-intrinsic phenotypes in multiple sclerosis. bioRxiv. 2023;: pubmed publisher
Liu Z, Chao J, Wang C, Sun G, Roeth D, Liu W, et al. Astrocytic response mediated by the CLU risk allele inhibits OPC proliferation and myelination in a human iPSC model. Cell Rep. 2023;42:112841 pubmed publisher
Werner L, Gliem M, Rychlik N, Pavic G, Reiche L, Kirchhoff F, et al. A Novel Ex Vivo Model to Study Therapeutic Treatments for Myelin Repair following Ischemic Damage. Int J Mol Sci. 2023;24: pubmed publisher
Scavuzzo M, Letai K, Maeno Hikichi Y, Wulftange W, Shah I, Rameshbabu J, et al. Enteric glial hub cells coordinate intestinal motility. bioRxiv. 2023;: pubmed publisher
Seixas A, Morais M, Brakebusch C, Relvas J. A RhoA-mediated biomechanical response in Schwann cells modulates peripheral nerve myelination. Prog Neurobiol. 2023;227:102481 pubmed publisher
Huang Z, Lin J, Jiang H, Lin W, Huang Z, Chen J, et al. Metformin promotes Schwann cell remyelination, preserves neural tissue and improves functional recovery after spinal cord injury. Neuropeptides. 2023;100:102348 pubmed publisher
Robinson B, Oster B, Robertson K, Kaltschmidt J. Loss of ASD-Related Molecule Cntnap2 Affects Colonic Motility in Mice. bioRxiv. 2023;: pubmed publisher
Fazal S, Mutschler C, Chen C, Turmaine M, Chen C, Hsueh Y, et al. SARM1 detection in myelinating glia: sarm1/Sarm1 is dispensable for PNS and CNS myelination in zebrafish and mice. Front Cell Neurosci. 2023;17:1158388 pubmed publisher
Rockel A, Wagner N, Spenger P, Erg xfc n S, W xf6 rsd xf6 rfer P. Neuro-mesodermal assembloids recapitulate aspects of peripheral nervous system development in vitro. Stem Cell Reports. 2023;18:1155-1165 pubmed publisher
Xing Y, Poh J, Chuang B, Moradi K, Mitew S, Richardson W, et al. High-efficiency pharmacogenetic ablation of oligodendrocyte progenitor cells in the adult mouse CNS. Cell Rep Methods. 2023;3:100414 pubmed publisher
Chen Y, Wu C, Peng S, Guo D, Ouyang H, Wei Y, et al. Single-Cell Characterization of the Frizzled 5 (Fz5) Mutant Mouse and Human Persistent Fetal Vasculature (PFV). Invest Ophthalmol Vis Sci. 2023;64:8 pubmed publisher
Li W, Berlinicke C, Huang Y, Giera S, McGrath A, Fang W, et al. High-throughput screening for myelination promoting compounds using human stem cell-derived oligodendrocyte progenitor cells. iScience. 2023;26:106156 pubmed publisher
Cohn E, Clayton B, Madhavan M, Yacoub S, Federov Y, Paul Friedman K, et al. Pervasive environmental chemicals impair oligodendrocyte development. bioRxiv. 2023;: pubmed publisher
Buller S, Kohnke S, Hansford R, Shimizu T, Richardson W, Blouet C. Median eminence myelin continuously turns over in adult mice. Mol Metab. 2023;69:101690 pubmed publisher
Li Z, Chen K, Shao Q, Lu H, Zhang X, Pu Y, et al. Nanoparticulate MgH2 ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress. J Neuroinflammation. 2023;20:16 pubmed publisher
G xf6 ttle P, Groh J, Reiche L, Gruchot J, Rychlik N, Werner L, et al. Teriflunomide as a therapeutic means for myelin repair. J Neuroinflammation. 2023;20:7 pubmed publisher
Levy M, García Diaz B, Sedel F, Baron van Evercooren A, Mozafari S. High Dose Pharmaceutical Grade Biotin (MD1003) Accelerates Differentiation of Murine and Grafted Human Oligodendrocyte Progenitor Cells In Vivo. Int J Mol Sci. 2022;23: pubmed publisher
Galante C, Marichal N, Scarante F, Ghayad L, Shi Y, Schuurmans C, et al. Enhanced proliferation of oligodendrocyte progenitor cells following retrovirus mediated Achaete-scute complex-like 1 overexpression in the postnatal cerebral cortex in vivo. Front Neurosci. 2022;16:919462 pubmed publisher
Zhao X, Huffman L, Hafner H, Athaiya M, Finneran M, Kalinski A, et al. The injured sciatic nerve atlas (iSNAT), insights into the cellular and molecular basis of neural tissue degeneration and regeneration. elife. 2022;11: pubmed publisher
Raja W, Neves E, Burke C, Jiang X, Xu P, Rhodes K, et al. Patient-derived three-dimensional cortical neurospheres to model Parkinson's disease. PLoS ONE. 2022;17:e0277532 pubmed publisher
Ideno H, Imaizumi K, Shimada H, Sanosaka T, Nemoto A, Kohyama J, et al. Human PSCs determine the competency of cerebral organoid differentiation via FGF signaling and epigenetic mechanisms. iScience. 2022;25:105140 pubmed publisher
Karras P, Bordeu I, Poźniak J, Nowosad A, Pazzi C, Van Raemdonck N, et al. A cellular hierarchy in melanoma uncouples growth and metastasis. Nature. 2022;610:190-198 pubmed publisher
Mapps A, Boehm E, Beier C, Keenan W, Langel J, Liu M, et al. Satellite glia modulate sympathetic neuron survival, activity, and autonomic function. elife. 2022;11: pubmed publisher
Kastriti M, Faure L, Von Ahsen D, Bouderlique T, Bostr xf6 m J, Solovieva T, et al. Schwann cell precursors represent a neural crest-like state with biased multipotency. EMBO J. 2022;41:e108780 pubmed publisher
Hu X, Agarwal N, Zhang M, Ernfors P, Kuner R, Nyengaard J, et al. Identification and quantification of nociceptive Schwann cells in mice with and without Streptozotocin-induced diabetes. J Chem Neuroanat. 2022;123:102118 pubmed publisher
Kameneva P, Melnikova V, Kastriti M, Kurtova A, Kryukov E, Murtazina A, et al. Serotonin limits generation of chromaffin cells during adrenal organ development. Nat Commun. 2022;13:2901 pubmed publisher
Piccolo F, Kastan N, Haremaki T, Tian Q, Laundos T, De Santis R, et al. Role of YAP in early ectodermal specification and a Huntington's Disease model of human neurulation. elife. 2022;11: pubmed publisher
Khandker L, Jeffries M, Chang Y, Mather M, Evangelou A, Bourne J, et al. Cholesterol biosynthesis defines oligodendrocyte precursor heterogeneity between brain and spinal cord. Cell Rep. 2022;38:110423 pubmed publisher
Donega V, van der Geest A, Sluijs J, van Dijk R, Wang C, Basak O, et al. Single-cell profiling of human subventricular zone progenitors identifies SFRP1 as a target to re-activate progenitors. Nat Commun. 2022;13:1036 pubmed publisher
Dady A, Davidson L, Halley P, Storey K. Human spinal cord in vitro differentiation pace is initially maintained in heterologous embryonic environments. elife. 2022;11: pubmed publisher
Velasco Aviles S, Patel N, Casillas Bajo A, Frutos Rinc xf3 n L, Velasco E, Gallar J, et al. A genetic compensatory mechanism regulated by Jun and Mef2d modulates the expression of distinct class IIa Hdacs to ensure peripheral nerve myelination and repair. elife. 2022;11: pubmed publisher
Manos J, Preiss C, Venkat N, Tamm J, Reinhardt P, Kwon T, et al. Uncovering specificity of endogenous TAU aggregation in a human iPSC-neuron TAU seeding model. iScience. 2022;25:103658 pubmed publisher
Zyner K, Simeone A, Flynn S, Doyle C, Marsico G, Adhikari S, et al. G-quadruplex DNA structures in human stem cells and differentiation. Nat Commun. 2022;13:142 pubmed publisher
Yang L, Li Z, Liu G, Li X, Yang Z. Developmental Origins of Human Cortical Oligodendrocytes and Astrocytes. Neurosci Bull. 2022;38:47-68 pubmed publisher
Paton K, Robichon K, Templeton N, Denny L, Al Abadey A, Luo D, et al. The Salvinorin Analogue, Ethoxymethyl Ether Salvinorin B, Promotes Remyelination in Preclinical Models of Multiple Sclerosis. Front Neurol. 2021;12:782190 pubmed publisher
Li R, Walsh P, Truong V, Petersen A, Dutton J, Hubel A. Differentiation of Human iPS Cells Into Sensory Neurons Exhibits Developmental Stage-Specific Cryopreservation Challenges. Front Cell Dev Biol. 2021;9:796960 pubmed publisher
Wang F, Ma X, Wu Y, Xu Y, Gu H, Wang D, et al. Neutralization of Hv1/HVCN1 With Antibody Enhances Microglia/Macrophages Myelin Clearance by Promoting Their Migration in the Brain. Front Cell Neurosci. 2021;15:768059 pubmed publisher
Kovler M, Gonzalez Salazar A, Fulton W, Lu P, Yamaguchi Y, Zhou Q, et al. Toll-like receptor 4-mediated enteric glia loss is critical for the development of necrotizing enterocolitis. Sci Transl Med. 2021;13:eabg3459 pubmed publisher
Kohnke S, Buller S, Nuzzaci D, Ridley K, Lam B, Pivonkova H, et al. Nutritional regulation of oligodendrocyte differentiation regulates perineuronal net remodeling in the median eminence. Cell Rep. 2021;36:109362 pubmed publisher
Duong P, Ma K, Ramesh R, Moran J, Won S, Svaren J. H3K27 demethylases are dispensable for activation of Polycomb-regulated injury response genes in peripheral nerve. J Biol Chem. 2021;297:100852 pubmed publisher
Kim K, Li C, Bunina D, Jeong H, Ghelman J, Yoon J, et al. Donor cell memory confers a metastable state of directly converted cells. Cell Stem Cell. 2021;28:1291-1306.e10 pubmed publisher
Gao T, Wright Jin E, Sengupta R, Anderson J, Heuckeroth R. Cell-autonomous retinoic acid receptor signaling has stage-specific effects on mouse enteric nervous system. JCI Insight. 2021;6: pubmed publisher
Kameneva P, Artemov A, Kastriti M, Faure L, Olsen T, Otte J, et al. Single-cell transcriptomics of human embryos identifies multiple sympathoblast lineages with potential implications for neuroblastoma origin. Nat Genet. 2021;53:694-706 pubmed publisher
Fang J, Sia J, Soto J, Wang P, Li L, Hsueh Y, et al. Skeletal muscle regeneration via the chemical induction and expansion of myogenic stem cells in situ or in vitro. Nat Biomed Eng. 2021;5:864-879 pubmed publisher
Chang K, Agrawal I, Vainshtein A, Ho W, Xin W, Tucker Kellogg G, et al. TDP-43 maximizes nerve conduction velocity by repressing a cryptic exon for paranodal junction assembly in Schwann cells. elife. 2021;10: pubmed publisher
Maas D, Eijsink V, van Hulten J, Panic R, De Weerd P, Homberg J, et al. Antioxidant treatment ameliorates prefrontal hypomyelination and cognitive deficits in a rat model of schizophrenia. Neuropsychopharmacology. 2021;46:1161-1171 pubmed publisher
Wagstaff L, Gomez Sanchez J, Fazal S, Otto G, Kilpatrick A, Michael K, et al. Failures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun. elife. 2021;10: pubmed publisher
Kaneko A, Naito K, Nakamura S, Miyahara K, Goto K, Obata H, et al. Influence of aging on the peripheral nerve repair process using an artificial nerve conduit. Exp Ther Med. 2021;21:168 pubmed publisher
Hulme A, McArthur J, Maksour S, Miellet S, Ooi L, Adams D, et al. Molecular and Functional Characterization of Neurogenin-2 Induced Human Sensory Neurons. Front Cell Neurosci. 2020;14:600895 pubmed publisher
García León J, García Diaz B, Eggermont K, Cáceres Palomo L, Neyrinck K, Madeiro da Costa R, et al. Generation of oligodendrocytes and establishment of an all-human myelinating platform from human pluripotent stem cells. Nat Protoc. 2020;15:3716-3744 pubmed publisher
Allan K, Hu L, Scavuzzo M, Morton A, Gevorgyan A, Cohn E, et al. Non-canonical Targets of HIF1a Impair Oligodendrocyte Progenitor Cell Function. Cell Stem Cell. 2021;28:257-272.e11 pubmed publisher
Chalfouh C, Guillou C, Hardouin J, Delarue Q, Li X, Duclos C, et al. The Regenerative Effect of Trans-spinal Magnetic Stimulation After Spinal Cord Injury: Mechanisms and Pathways Underlying the Effect. Neurotherapeutics. 2020;17:2069-2088 pubmed publisher
Walsh P, Truong V, Nayak S, Sald xed as Montivero M, Low W, Parr A, et al. Accelerated differentiation of human pluripotent stem cells into neural lineages via an early intermediate ectoderm population. Stem Cells. 2020;38:1400-1408 pubmed publisher
Catignas K, Frick L, Pellegatta M, Hurley E, Kolb Z, Addabbo K, et al. αV integrins in Schwann cells promote attachment to axons, but are dispensable in vivo. Glia. 2020;: pubmed publisher
Wang Z, Jung J, Inbar T, Rangoussis K, Faaborg Andersen C, Coate T. The Purinergic Receptor P2rx3 is Required for Spiral Ganglion Neuron Branch Refinement during Development. Eneuro. 2020;7: pubmed publisher
Elitt M, Barbar L, Shick H, Powers B, Maeno Hikichi Y, Madhavan M, et al. Suppression of proteolipid protein rescues Pelizaeus-Merzbacher disease. Nature. 2020;585:397-403 pubmed publisher
Vue T, Kollipara R, Borromeo M, Smith T, Mashimo T, Burns D, et al. ASCL1 regulates neurodevelopmental transcription factors and cell cycle genes in brain tumors of glioma mouse models. Glia. 2020;68:2613-2630 pubmed publisher
Maas D, Eijsink V, Spoelder M, van Hulten J, De Weerd P, Homberg J, et al. Interneuron hypomyelination is associated with cognitive inflexibility in a rat model of schizophrenia. Nat Commun. 2020;11:2329 pubmed publisher
Nagy C, Maitra M, Tanti A, Suderman M, Théroux J, Davoli M, et al. Single-nucleus transcriptomics of the prefrontal cortex in major depressive disorder implicates oligodendrocyte precursor cells and excitatory neurons. Nat Neurosci. 2020;23:771-781 pubmed publisher
Factor D, Barbeau A, Allan K, Hu L, Madhavan M, Hoang A, et al. Cell Type-Specific Intralocus Interactions Reveal Oligodendrocyte Mechanisms in MS. Cell. 2020;181:382-395.e21 pubmed publisher
Alshehri B, Pagnin M, Lee J, Petratos S, Richardson S. The Role of Transthyretin in Oligodendrocyte Development. Sci Rep. 2020;10:4189 pubmed publisher
Brooks P, Rose K, MacRae M, Rangoussis K, Gurjar M, Hertzano R, et al. Pou3f4-expressing otic mesenchyme cells promote spiral ganglion neuron survival in the postnatal mouse cochlea. J Comp Neurol. 2020;528:1967-1985 pubmed publisher
Tripathi A, Volsko C, Garcia J, Agirre E, Allan K, Tesar P, et al. Oligodendrocyte Intrinsic miR-27a Controls Myelination and Remyelination. Cell Rep. 2019;29:904-919.e9 pubmed publisher
Wang Q, Kurosaka H, Kikuchi M, Nakaya A, Trainor P, Yamashiro T. Perturbed development of cranial neural crest cells in association with reduced sonic hedgehog signaling underlies the pathogenesis of retinoic-acid-induced cleft palate. Dis Model Mech. 2019;12: pubmed publisher
Ommer A, Figlia G, Pereira J, Datwyler A, Gerber J, Degeer J, et al. Ral GTPases in Schwann cells promote radial axonal sorting in the peripheral nervous system. J Cell Biol. 2019;: pubmed publisher
Wiszniak S, Schwarz Q. Notch signalling defines dorsal root ganglia neuroglial fate choice during early neural crest cell migration. BMC Neurosci. 2019;20:21 pubmed publisher
García Diaz B, Bachelin C, Coulpier F, Gerschenfeld G, Deboux C, Zujovic V, et al. Blood vessels guide Schwann cell migration in the adult demyelinated CNS through Eph/ephrin signaling. Acta Neuropathol. 2019;: pubmed publisher
Yeung M, Djelloul M, Steiner E, Bernard S, Salehpour M, Possnert G, et al. Dynamics of oligodendrocyte generation in multiple sclerosis. Nature. 2019;566:538-542 pubmed publisher
Gerber D, Ghidinelli M, Tinelli E, Somandin C, Gerber J, Pereira J, et al. Schwann cells, but not Oligodendrocytes, Depend Strictly on Dynamin 2 Function. elife. 2019;8: pubmed publisher
Kozlenkov A, Li J, Apontes P, Hurd Y, BYNE W, Koonin E, et al. A unique role for DNA (hydroxy)methylation in epigenetic regulation of human inhibitory neurons. Sci Adv. 2018;4:eaau6190 pubmed publisher
Lager A, Corradin O, Cregg J, Elitt M, Shick H, Clayton B, et al. Rapid functional genetics of the oligodendrocyte lineage using pluripotent stem cells. Nat Commun. 2018;9:3708 pubmed publisher
Piacentino M, Bronner M. Intracellular attenuation of BMP signaling via CKIP-1/Smurf1 is essential during neural crest induction. PLoS Biol. 2018;16:e2004425 pubmed publisher
Zhao C, Dong C, Frah M, Deng Y, Marie C, Zhang F, et al. Dual Requirement of CHD8 for Chromatin Landscape Establishment and Histone Methyltransferase Recruitment to Promote CNS Myelination and Repair. Dev Cell. 2018;45:753-768.e8 pubmed publisher
Winkler C, Yabut O, Fregoso S, Gomez H, Dwyer B, Pleasure S, et al. The Dorsal Wave of Neocortical Oligodendrogenesis Begins Embryonically and Requires Multiple Sources of Sonic Hedgehog. J Neurosci. 2018;38:5237-5250 pubmed publisher
Kelenis D, Hart E, Edwards Fligner M, Johnson J, Vue T. ASCL1 regulates proliferation of NG2-glia in the embryonic and adult spinal cord. Glia. 2018;66:1862-1880 pubmed publisher
Choi S, Bin B, Kim W, Lee E, Lee T, Cho E. Exposure of human melanocytes to UVB twice and subsequent incubation leads to cellular senescence and senescence-associated pigmentation through the prolonged p53 expression. J Dermatol Sci. 2018;90:303-312 pubmed publisher
Chen M, Laursen S, Habekost M, Knudsen C, Buchholdt S, Huang J, et al. Central and Peripheral Nervous System Progenitors Derived from Human Pluripotent Stem Cells Reveal a Unique Temporal and Cell-Type Specific Expression of PMCAs. Front Cell Dev Biol. 2018;6:5 pubmed publisher
Abu Bonsrah K, Zhang D, Bjorksten A, Dottori M, Newgreen D. Generation of Adrenal Chromaffin-like Cells from Human Pluripotent Stem Cells. Stem Cell Reports. 2018;10:134-150 pubmed publisher
Gandhi S, Piacentino M, Vieceli F, Bronner M. Optimization of CRISPR/Cas9 genome editing for loss-of-function in the early chick embryo. Dev Biol. 2017;432:86-97 pubmed publisher
Fazal S, Gomez Sanchez J, Wagstaff L, Musner N, Otto G, Janz M, et al. Graded Elevation of c-Jun in Schwann Cells In Vivo: Gene Dosage Determines Effects on Development, Remyelination, Tumorigenesis, and Hypomyelination. J Neurosci. 2017;37:12297-12313 pubmed publisher
Mori T, Sukeda A, Sekine S, Shibata S, Ryo E, Okano H, et al. SOX10 Expression as Well as BRAF and GNAQ/11 Mutations Distinguish Pigmented Ciliary Epithelium Neoplasms From Uveal Melanomas. Invest Ophthalmol Vis Sci. 2017;58:5445-5451 pubmed publisher
Figlia G, Norrmen C, Pereira J, Gerber D, Suter U. Dual function of the PI3K-Akt-mTORC1 axis in myelination of the peripheral nervous system. elife. 2017;6: pubmed publisher
Clayton B, Huang A, Kunjamma R, Solanki A, Popko B. The integrated stress response in hypoxia-induced diffuse white matter injury. J Neurosci. 2017;: pubmed publisher
McLane L, Bourne J, Evangelou A, Khandker L, Macklin W, Wood T. Loss of Tuberous Sclerosis Complex1 in Adult Oligodendrocyte Progenitor Cells Enhances Axon Remyelination and Increases Myelin Thickness after a Focal Demyelination. J Neurosci. 2017;37:7534-7546 pubmed publisher
Nevin Z, Factor D, Karl R, Douvaras P, Laukka J, Windrem M, et al. Modeling the Mutational and Phenotypic Landscapes of Pelizaeus-Merzbacher Disease with Human iPSC-Derived Oligodendrocytes. Am J Hum Genet. 2017;100:617-634 pubmed publisher
Toyoshima M, Akamatsu W, Okada Y, Ohnishi T, Balan S, Hisano Y, et al. Analysis of induced pluripotent stem cells carrying 22q11.2 deletion. Transl Psychiatry. 2016;6:e934 pubmed publisher
Poitelon Y, Lopez Anido C, Catignas K, Berti C, Palmisano M, Williamson C, et al. YAP and TAZ control peripheral myelination and the expression of laminin receptors in Schwann cells. Nat Neurosci. 2016;19:879-87 pubmed publisher
Blokzijl A, Chen L, Gustafsdottir S, Vuu J, Ullenhag G, Kämpe O, et al. Elevated Levels of SOX10 in Serum from Vitiligo and Melanoma Patients, Analyzed by Proximity Ligation Assay. PLoS ONE. 2016;11:e0154214 pubmed publisher
product information
brand :
R&D Systems
master code :
AF2864
SKU :
AF2864
product name :
Human SOX10 Antibody
unit size :
100 ug (also 25 ug)
seo description :
The Human SOX10 Antibody from R&D Systems is a goat polyclonal antibody to SOX10. This antibody reacts with avian - chicken,human,mouse,rat,transgenic mouse,xenograft. The Human SOX10 Antibody has been validated for the following applications: Immunohistochemistry,Immunocytochemistry,In Situ,Flow Cytometry,FACS,IHC/IF,IHC-F,Proximity Ligation Assay (PLA),Immunoprecipitation,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry/ Immunofluorescence.
target :
SOX10
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Polyclonal
concentration :
LYOPH
conjugate :
Unconjugated
dilution :
Western Blot 0.1 ug/mL, Immunohistochemistry 5-15 ug/mL, Immunocytochemistry 5-15 ug/mL
host :
Goat
immunogen :
E. coli -derived recombinant human SOX10, Met1-Ala118, Accession # P56693
isotype :
IgG
purity :
Antigen Affinity-purified
species :
Avian - Chicken,Human,Mouse,Rat,Transgenic Mouse,Xenograft
specificity :
Detects human SOX10 in direct ELISAs and Western blots.
gene symbol :
SOX10
accessionNumbers :
P56693
applications :
FACS,IHC/IF,IHC-F,In Situ,Proximity Ligation Assay (PLA),Flow Cytometry,Immunohistochemistry,Immunoprecipitation,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry,Immunocytochemistry/ Immunofluorescence
USD :
519 USD
alt names :
DOM, MGC15649, PCWH, SRY (sex determining region Y)-box 10, SRY-related HMG-box gene 10, transcription factor SOX-10, WS4, WS4C, WS4mouse, human homolog of
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.