Human HGFR/c-MET Antibody | R&D Systems AF276 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human HGFR/c-MET Antibody

catalog :

AF276

quantity :

100 ug (also 25 ug)

price :

499 USD

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human, dogs

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, neutralization, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section

more info or order :

R&D Systems product webpage

citations: 27

Reference
Tarvestad Laise K, Ceresa B. Knockout of c-Cbl/Cbl-b slows c-Met trafficking resulting in enhanced signaling in corneal epithelial cells. J Biol Chem. 2023;299:105233 pubmed publisher
Phan Q, Solis N, Cravener M, Swidergall M, Lin J, Huang M, et al. Candida albicans stimulates formation of a multi-receptor complex that mediates epithelial cell invasion during oropharyngeal infection. PLoS Pathog. 2023;19:e1011579 pubmed publisher
Song K, Han Y, Roehrich H, Brown M, Torres Cabala C, Giubellino A. MET Receptor Tyrosine Kinase Inhibition Reduces Interferon-Gamma (IFN-γ)-Stimulated PD-L1 Expression through the STAT3 Pathway in Melanoma Cells. Cancers (Basel). 2023;15: pubmed publisher
Modica C, Cortese M, Bersani F, Lombardi A, Napoli F, Righi L, et al. Genetic Ablation of the MET Oncogene Defines a Crucial Role of the HGF/MET Axis in Cell-Autonomous Functions Driving Tumor Dissemination. Cancers (Basel). 2023;15: pubmed publisher
Koo K, Wuenschmann A, Rendahl A, Song K, Forster C, Wolf Ringwall A, et al. Expression and Prognostic Evaluation of the Receptor Tyrosine Kinase MET in Canine Malignant Melanoma. Vet Sci. 2023;10: pubmed publisher
Phan Q, Solis N, Cravener M, Swidergall M, Lin J, Huang M, et al. Candida albicans stimulates the formation of a multi-receptor complex that mediates epithelial cell invasion during oropharyngeal infection. bioRxiv. 2023;: pubmed publisher
Zuo Q, Yang Y, Lyu Y, Yang C, Chen C, Salman S, et al. Plexin-B3 expression stimulates MET signaling, breast cancer stem cell specification, and lung metastasis. Cell Rep. 2023;42:112164 pubmed publisher
Mesquita B, Fens M, Di Maggio A, Bosman E, Hennink W, Heger M, et al. The Impact of Nanobody Density on the Targeting Efficiency of PEGylated Liposomes. Int J Mol Sci. 2022;23: pubmed publisher
Nair A, Bu J, Rawding P, Do S, Li H, Hong S. Cytochalasin B Treatment and Osmotic Pressure Enhance the Production of Extracellular Vesicles (EVs) with Improved Drug Loading Capacity. Nanomaterials (Basel). 2021;12: pubmed publisher
Zhang Q, Jeppesen D, Higginbotham J, Graves Deal R, Trinh V, Ramirez M, et al. Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets. Nat Cell Biol. 2021;23:1240-1254 pubmed publisher
Banerjee P, Xiao G, Tan X, Zheng V, Shi L, Rabassedas M, et al. The EMT activator ZEB1 accelerates endosomal trafficking to establish a polarity axis in lung adenocarcinoma cells. Nat Commun. 2021;12:6354 pubmed publisher
Nászai M, Bellec K, Yu Y, Román Fernández Á, Sandilands E, Johansson J, et al. RAL GTPases mediate EGFR-driven intestinal stem cell proliferation and tumourigenesis. elife. 2021;10: pubmed publisher
Marsh B, Blelloch R. Single nuclei RNA-seq of mouse placental labyrinth development. elife. 2020;9: pubmed publisher
Fedeli C, Moreno H, Kunz S. The Role of Receptor Tyrosine Kinases in Lassa Virus Cell Entry. Viruses. 2020;12: pubmed publisher
Xiao G, Schmid S. FCHSD2 controls oncogenic ERK1/2 signaling outcome by regulating endocytic trafficking. PLoS Biol. 2020;18:e3000778 pubmed publisher
Guo R, Luo J, Chang J, Rekhtman N, Arcila M, Drilon A. MET-dependent solid tumours - molecular diagnosis and targeted therapy. Nat Rev Clin Oncol. 2020;17:569-587 pubmed publisher
Harwardt M, Schr xf6 der M, Li Y, Malkusch S, Freund P, Gupta S, et al. Single-Molecule Super-Resolution Microscopy Reveals Heteromeric Complexes of MET and EGFR upon Ligand Activation. Int J Mol Sci. 2020;21: pubmed publisher
Lyashenko E, Niepel M, Dixit P, Lim S, Sorger P, Vitkup D. Receptor-based mechanism of relative sensing and cell memory in mammalian signaling networks. elife. 2020;9: pubmed publisher
Graves Deal R, Bogatcheva G, Rehman S, Lu Y, Higginbotham J, Singh B. Broad-spectrum receptor tyrosine kinase inhibitors overcome de novo and acquired modes of resistance to EGFR-targeted therapies in colorectal cancer. Oncotarget. 2019;10:1320-1333 pubmed publisher
Li W, Dick A, Lu F, Zhang H, Sun H. Induction of MET Receptor Tyrosine Kinase Down-regulation through Antibody-mediated Receptor Clustering. Sci Rep. 2019;9:1988 pubmed publisher
Zaoui K, Duhamel S, Parachoniak C, Park M. CLIP-170 spatially modulates receptor tyrosine kinase recycling to coordinate cell migration. Traffic. 2019;20:187-201 pubmed publisher
Novo D, Heath N, Mitchell L, Caligiuri G, MacFarlane A, Reijmer D, et al. Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels. Nat Commun. 2018;9:5069 pubmed publisher
Xiao J, Li X, Liu L, Wang G, Hao S, Dong H, et al. The association of semaphorin 5A with lymph node metastasis and adverse prognosis in cervical cancer. Cancer Cell Int. 2018;18:87 pubmed publisher
Scott M, Coleman D, Kelly K, Carroll J, Woodby B, Songock W, et al. Human papillomavirus type 16 E5-mediated upregulation of Met in human keratinocytes. Virology. 2018;519:1-11 pubmed publisher
Alghanem A, Wilkinson E, Emmett M, Aljasir M, Holmes K, Rothermel B, et al. RCAN1.4 regulates VEGFR-2 internalisation, cell polarity and migration in human microvascular endothelial cells. Angiogenesis. 2017;20:341-358 pubmed publisher
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product information

brand :

R&D Systems

master code :

AF276

SKU :

AF276

product name :

Human HGFR/c-MET Antibody

unit size :

100 ug (also 25 ug)

seo description :

The Human HGFR/c-MET Antibody from R&D Systems is a goat polyclonal antibody to HGFR/c-MET. This antibody reacts with canine,human. The Human HGFR/c-MET Antibody has been validated for the following applications: Immunocytochemistry,Bioassay,ELISA Development (Detection),Flow Cytometry,Immunoprecipitation,Western Blot,Neutralization,ELISA Capture,Immunohistochemistry-Paraffin,Immunohistochemistry,Simple Western,Blockade of Receptor-ligand Interaction,CyTOF-ready,Knockout Validated.

target :

HGFR/c-MET

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Polyclonal

concentration :

LYOPH

conjugate :

Unconjugated

dilution :

Western Blot 0.1 ug/mL, Simple Western 25 ug/mL, Flow Cytometry 2.5 ug/10^6 cells, Immunohistochemistry 5-15 ug/mL, Blockade of Receptor-ligand Interaction, Immunocytochemistry 5-15 ug/mL, CyTOF-ready, Knockout Validated

host :

Goat

immunogen :

Mouse myeloma cell line NS0-derived recombinant human HGF R/c-MET, Glu25-Thr932, Accession # P08581

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Canine,Human

specificity :

Detects human HGF R/c-MET in direct ELISAs and Western blots. In direct ELISAs and Western blots, approximately 30% cross-reactivity with recombinant mouse HGF R is observed.

gene symbol :

MET

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

Antibody validation :

Knockout/Knockdown

top caption :

HGF R/c-MET antibody in HT-29 and U937 Human Cell Line by Immunocytochemistry (ICC).

accessionNumbers :

P08581

applications :

Immunohistochemistry,Simple Western,Blockade of Receptor-ligand Interaction,CyTOF-ready,Knockout Validated,Bioassay,ELISA Development (Detection),Flow Cytometry,Immunoprecipitation,Western Blot,Immunohistochemistry-Paraffin,Neutralization,Immunocytochemistry,ELISA Capture

USD :

499 USD

alt names :

AUTS9, c-Met, cMET, EC 2.7.10, EC 2.7.10.1, hepatocyte growth factor receptor, HGF R, HGF receptor, HGF/SF receptor, HGFR, MET, Met (c-Met), met proto-oncogene (hepatocyte growth factor receptor), met proto-oncogene tyrosine kinase, oncogene MET, Proto-oncogene c-Met, RCCP2, Scatter factor receptor, SF receptor, Tyrosine-protein kinase Met

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage