product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human Prox1 Antibody
catalog :
AF2727
quantity :
100 ug (also 25 ug)
price :
509 USD
clonality :
polyclonal
host :
domestic goat
conjugate :
nonconjugated
reactivity :
human, mouse, rat, chicken, zebrafish
application :
western blot, immunohistochemistry, immunocytochemistry, flow cytometry, chromatin immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 116
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - frozen section; mouse; 1:1000; loading ...; fig 1c
Stachniak T, Kastli R, Hanley O, Argunşah A, van der Valk E, Kanatouris G, et al. Postmitotic Prox1 Expression Controls the Final Specification of Cortical VIP Interneuron Subtypes. J Neurosci. 2021;41:8150-8162 pubmed publisher
  • immunohistochemistry; mouse; 1:40; loading ...; fig 3e
Åmellem I, Yovianto G, Chong H, Nair R, Cnops V, Thanawalla A, et al. Role of NMDA Receptors in Adult Neurogenesis and Normal Development of the Dentate Gyrus. Eneuro. 2021;8: pubmed publisher
  • immunohistochemistry; mouse; 1:200; loading ...; fig 4a
Maruyama K, Naemura K, Arima Y, Uchijima Y, Nagao H, Yoshihara K, et al. Semaphorin3E-PlexinD1 signaling in coronary artery and lymphatic vessel development with clinical implications in myocardial recovery. iScience. 2021;24:102305 pubmed publisher
  • immunohistochemistry; mouse; 1:200; loading ...; fig 3e, 4b, s3b
Dieterich L, Tacconi C, Menzi F, Proulx S, Kapaklikaya K, Hamada M, et al. Lymphatic MAFB regulates vascular patterning during developmental and pathological lymphangiogenesis. Angiogenesis. 2020;23:411-423 pubmed publisher
Spurgin S, Nguimtsop A, Chaudhry F, Michki S, Salvador J, Iruela Arispe M, et al. Spatiotemporal dynamics of primary and motile cilia throughout lung development. bioRxiv. 2024;: pubmed publisher
Manolis D, Hasan S, Maraveyas A, O Brien D, Kessler B, Kramer H, et al. Quantitative proteomics reveals CLR interactome in primary human cells. J Biol Chem. 2024;300:107399 pubmed publisher
Crossey E, Carty S, Shao F, Henao Vasquez J, Ysasi A, Zeng M, et al. Influenza Induces Lung Lymphangiogenesis Independent of YAP/TAZ Activity in Lymphatic Endothelial Cells. Res Sq. 2024;: pubmed publisher
Sun Q, Li J, Ma J, Zheng Y, Ju R, Li X, et al. JAM-C Is Important for Lens Epithelial Cell Proliferation and Lens Fiber Maturation in Murine Lens Development. Invest Ophthalmol Vis Sci. 2023;64:15 pubmed publisher
Ong A, Kokaji T, Kishi A, Takihara Y, Shinozuka T, Shimamoto R, et al. Acquisition of neural fate by combination of BMP blockade and chromatin modification. iScience. 2023;26:107887 pubmed publisher
Jain S, Lafrancois J, Gerencer K, Botterill J, Kennedy M, Criscuolo C, et al. Increasing adult neurogenesis protects mice from epilepsy. bioRxiv. 2023;: pubmed publisher
Jannaway M, Iyer D, Mastrogiacomo D, Li K, Sung D, Yang Y, et al. VEGFR3 is required for button junction formation in lymphatic vessels. Cell Rep. 2023;42:112777 pubmed publisher
Maunsell H, Ellis K, Kelley M, Driver E. Lrrn1 Regulates Medial Boundary Formation in the Developing Mouse Organ of Corti. J Neurosci. 2023;43:5305-5318 pubmed publisher
Ohata H, Shiokawa D, Sakai H, Kanda Y, Okimoto Y, Kaneko S, et al. PROX1 induction by autolysosomal activity stabilizes persister-like state of colon cancer via feedback repression of the NOX1-mTORC1 pathway. Cell Rep. 2023;:112519 pubmed publisher
Blinkiewicz P, Long M, Stoner Z, Ketchum E, Sheltz Kempf S, Duncan J. Gata3 is Required in Late Proneurosensory Development for Proper Sensory Cell Formation and Organization. Res Sq. 2023;: pubmed publisher
Greene D, Pirri D, Frudd K, Sackey E, Al Owain M, Giese A, et al. Genetic association analysis of 77,539 genomes reveals rare disease etiologies. Nat Med. 2023;29:679-688 pubmed publisher
Chiang I, Graus M, Kirschnick N, Davidson T, Luu W, Harwood R, et al. The blood vasculature instructs lymphatic patterning in a SOX7-dependent manner. EMBO J. 2023;42:e109032 pubmed publisher
Kazenwadel J, Venugopal P, Oszmiana A, Toubia J, Arriola Martinez L, Panara V, et al. A Prox1 enhancer represses haematopoiesis in the lymphatic vasculature. Nature. 2023;614:343-348 pubmed publisher
Arroyo Ataz G, Jones D. Dissection of murine collecting lymphatic vessels for imaging, single-cell analysis, and tissue culture of lymphatic muscle cells. STAR Protoc. 2022;3:101800 pubmed publisher
Bonet F, A xf1 ez S, In xe1 cio J, Futschik M, Belo J. CCBE1 Is Essential for Epicardial Function during Myocardium Development. Int J Mol Sci. 2022;23: pubmed publisher
Wakao S, Oguma Y, Kushida Y, Kuroda Y, Tatsumi K, Dezawa M. Phagocytosing differentiated cell-fragments is a novel mechanism for controlling somatic stem cell differentiation within a short time frame. Cell Mol Life Sci. 2022;79:542 pubmed publisher
Maruyama K, Miyagawa Tomita S, Haneda Y, Kida M, Matsuzaki F, Imanaka Yoshida K, et al. The cardiopharyngeal mesoderm contributes to lymphatic vessel development in mouse. elife. 2022;11: pubmed publisher
Kim N, Kim M, Woo S, Han I, Park J, Kim K, et al. Single-cell transcriptomics reveal cellular diversity of aortic valve and the immunomodulation by PPARγ during hyperlipidemia. Nat Commun. 2022;13:5461 pubmed publisher
Place E, Manning E, Kim D, Kinjo A, Nakamura G, Ohyama K. SHH and Notch regulate SOX9+ progenitors to govern arcuate POMC neurogenesis. Front Neurosci. 2022;16:855288 pubmed publisher
Zhou Y, Su Y, Li S, Kennedy B, Zhang D, Bond A, et al. Molecular landscapes of human hippocampal immature neurons across lifespan. Nature. 2022;607:527-533 pubmed publisher
Wong F, Selten M, Rosés Novella C, Sreenivasan V, Pallas Bazarra N, Serafeimidou Pouliou E, et al. Serotonergic regulation of bipolar cell survival in the developing cerebral cortex. Cell Rep. 2022;40:111037 pubmed publisher
Jacob L, de Brito Neto J, Lenck S, Corcy C, Benbelkacem F, Geraldo L, et al. Conserved meningeal lymphatic drainage circuits in mice and humans. J Exp Med. 2022;219: pubmed publisher
Hall A, Pohl S, Cammareri P, Aitken S, Younger N, Raponi M, et al. RNA splicing is a key mediator of tumour cell plasticity and a therapeutic vulnerability in colorectal cancer. Nat Commun. 2022;13:2791 pubmed publisher
Choudhury A, Magill S, Eaton C, Prager B, Chen W, Cady M, et al. Meningioma DNA methylation groups identify biological drivers and therapeutic vulnerabilities. Nat Genet. 2022;54:649-659 pubmed publisher
Genescu I, An xed bal Mart xed nez M, Kouskoff V, Chenouard N, Mailhes Hamon C, Cartonnet H, et al. Dynamic interplay between thalamic activity and Cajal-Retzius cells regulates the wiring of cortical layer 1. Cell Rep. 2022;39:110667 pubmed publisher
Xu J, Xu L, Sui P, Chen J, Moya E, Hume P, et al. Excess neuropeptides in lung signal through endothelial cells to impair gas exchange. Dev Cell. 2022;57:839-853.e6 pubmed publisher
Cornille M, Moriceau S, Khonsari R, Heuz xe9 Y, Loisay L, Boitez V, et al. FGFR3 overactivation in the brain is responsible for memory impairments in Crouzon syndrome mouse model. J Exp Med. 2022;219: pubmed publisher
Friess M, Kritikos I, Schineis P, Medina Sanchez J, Gkountidi A, Vallone A, et al. Mechanosensitive ACKR4 scavenges CCR7 chemokines to facilitate T cell de-adhesion and passive transport by flow in inflamed afferent lymphatics. Cell Rep. 2022;38:110334 pubmed publisher
Baluk P, McDonald D. Imaging Blood Vessels and Lymphatics in Mouse Trachea Wholemounts. Methods Mol Biol. 2022;2441:115-134 pubmed publisher
Wakizono T, Nakashima H, Yasui T, Noda T, Aoyagi K, Okada K, et al. Growth factors with valproic acid restore injury-impaired hearing by promoting neuronal regeneration. JCI Insight. 2021;6: pubmed publisher
Czepielewski R, Erlich E, Onufer E, Young S, Saunders B, Han Y, et al. Ileitis-associated tertiary lymphoid organs arise at lymphatic valves and impede mesenteric lymph flow in response to tumor necrosis factor. Immunity. 2021;54:2795-2811.e9 pubmed publisher
Wang T, Wang Z, De Fabritus L, Tao J, Saied E, Lee H, et al. 1-deoxysphingolipids bind to COUP-TF to modulate lymphatic and cardiac cell development. Dev Cell. 2021;56:3128-3145.e15 pubmed publisher
Olmeda D, Cerezo Wallis D, Mucientes C, Calvo T, Cañón E, Alonso Curbelo D, et al. Live imaging of neolymphangiogenesis identifies acute antimetastatic roles of dsRNA mimics. EMBO Mol Med. 2021;13:e12924 pubmed publisher
Thomson B, Liu P, Onay T, Du J, Tompson S, Misener S, et al. Cellular crosstalk regulates the aqueous humor outflow pathway and provides new targets for glaucoma therapies. Nat Commun. 2021;12:6072 pubmed publisher
Nawarawong N, Thompson K, Guerin S, Anasooya Shaji C, Peng H, Nixon K. Reactive, Adult Neurogenesis From Increased Neural Progenitor Cell Proliferation Following Alcohol Dependence in Female Rats. Front Neurosci. 2021;15:689601 pubmed publisher
Redder E, Kirschnick N, Bobe S, Hägerling R, Hansmeier N, Kiefer F. Vegfr3-tdTomato, a reporter mouse for microscopic visualization of lymphatic vessel by multiple modalities. PLoS ONE. 2021;16:e0249256 pubmed publisher
Otsu M, Ahmed Z, Fulton D. Generation of Multipotential NG2 Progenitors From Mouse Embryonic Stem Cell-Derived Neural Stem Cells. Front Cell Dev Biol. 2021;9:688283 pubmed publisher
Uemura M, Blankvoort S, Tok S, Yuan L, Cobar L, Lit K, et al. A neurogenic microenvironment defined by excitatory-inhibitory neuronal circuits in adult dentate gyrus. Cell Rep. 2021;36:109324 pubmed publisher
Billings S, Myers N, Quiruz L, Cheng A. Opposing effects of Wnt/β-catenin signaling on epithelial and mesenchymal cell fate in the developing cochlea. Development. 2021;148: pubmed publisher
Paulson D, Harms R, Ward C, Latterell M, Pazour G, Fink D. Loss of Primary Cilia Protein IFT20 Dysregulates Lymphatic Vessel Patterning in Development and Inflammation. Front Cell Dev Biol. 2021;9:672625 pubmed publisher
Ma W, Gil H, Liu X, Diebold L, Morgan M, Oxendine Burns M, et al. Mitochondrial respiration controls the Prox1-Vegfr3 feedback loop during lymphatic endothelial cell fate specification and maintenance. Sci Adv. 2021;7: pubmed publisher
Schaller J, Hajjami H, Rusakiewicz S, Ioannidou K, Piazzon N, Miles A, et al. Mutually exclusive lymphangiogenesis or perineural infiltration in human skin squamous-cell carcinoma. Oncotarget. 2021;12:638-648 pubmed publisher
Limoni G, Murthy S, Jabaudon D, Dayer A, Niquille M. PlexinA4-Semaphorin3A-mediated crosstalk between main cortical interneuron classes is required for superficial interneuron lamination. Cell Rep. 2021;34:108644 pubmed publisher
Tai Nagara I, Hasumi Y, Kusumoto D, Hasumi H, Okabe K, Ando T, et al. Blood and lymphatic systems are segregated by the FLCN tumor suppressor. Nat Commun. 2020;11:6314 pubmed publisher
Motawe Z, Abdelmaboud S, Breslin J. Involvement of Sigma Receptor-1 in Lymphatic Endothelial Barrier Integrity and Bioenergetic Regulation. Lymphat Res Biol. 2021;19:231-239 pubmed publisher
Rattner A, Terrillion C, Jou C, Kleven T, Hu S, Williams J, et al. Developmental, cellular, and behavioral phenotypes in a mouse model of congenital hypoplasia of the dentate gyrus. elife. 2020;9: pubmed publisher
Cha B, Ho Y, Geng X, Mahamud M, Chen L, Kim Y, et al. YAP and TAZ maintain PROX1 expression in the developing lymphatic and lymphovenous valves in response to VEGF-C signaling. Development. 2020;147: pubmed publisher
Thomson B, Grannonico M, Liu F, Liu M, Mendapara P, Xu Y, et al. Angiopoietin-1 Knockout Mice as a Genetic Model of Open-Angle Glaucoma. Transl Vis Sci Technol. 2020;9:16 pubmed publisher
Hong S, Yang M, Cho H, Park I, Bae H, Choe K, et al. Distinct fibroblast subsets regulate lacteal integrity through YAP/TAZ-induced VEGF-C in intestinal villi. Nat Commun. 2020;11:4102 pubmed publisher
Kadosh E, Snir Alkalay I, Venkatachalam A, May S, Lasry A, Elyada E, et al. The gut microbiome switches mutant p53 from tumour-suppressive to oncogenic. Nature. 2020;586:133-138 pubmed publisher
Geng X, Yanagida K, Akwii R, Choi D, Chen L, Ho Y, et al. S1PR1 regulates the quiescence of lymphatic vessels by inhibiting laminar shear stress-dependent VEGF-C signaling. JCI Insight. 2020;5: pubmed publisher
Gramolelli S, Elbasani E, Tuohinto K, Nurminen V, Gunther T, Kallinen R, et al. Oncogenic Herpesvirus Engages Endothelial Transcription Factors SOX18 and PROX1 to Increase Viral Genome Copies and Virus Production. Cancer Res. 2020;80:3116-3129 pubmed publisher
Norden P, Sabine A, Wang Y, Demir C, Liu T, Petrova T, et al. Shear stimulation of FOXC1 and FOXC2 differentially regulates cytoskeletal activity during lymphatic valve maturation. elife. 2020;9: pubmed publisher
Xiang M, Grosso R, Takeda A, Pan J, Bekkhus T, Brulois K, et al. A Single-Cell Transcriptional Roadmap of the Mouse and Human Lymph Node Lymphatic Vasculature. Front Cardiovasc Med. 2020;7:52 pubmed publisher
Akiyama G, Saraswathy S, Bogarin T, Pan X, Barron E, Wong T, et al. Functional, structural, and molecular identification of lymphatic outflow from subconjunctival blebs. Exp Eye Res. 2020;196:108049 pubmed publisher
Yoshimatsu Y, Kimuro S, Pauty J, Takagaki K, Nomiyama S, Inagawa A, et al. TGF-beta and TNF-alpha cooperatively induce mesenchymal transition of lymphatic endothelial cells via activation of Activin signals. PLoS ONE. 2020;15:e0232356 pubmed publisher
Roy A, Millen K, Kapur R. Hippocampal granule cell dispersion: a non-specific finding in pediatric patients with no history of seizures. Acta Neuropathol Commun. 2020;8:54 pubmed publisher
Fujimoto N, He Y, D Addio M, Tacconi C, Detmar M, Dieterich L. Single-cell mapping reveals new markers and functions of lymphatic endothelial cells in lymph nodes. PLoS Biol. 2020;18:e3000704 pubmed publisher
Betterman K, Sutton D, Secker G, Kazenwadel J, Oszmiana A, Lim L, et al. Atypical cadherin FAT4 orchestrates lymphatic endothelial cell polarity in response to flow. J Clin Invest. 2020;130:3315-3328 pubmed publisher
Hu X, Deng Q, Ma L, Li Q, Chen Y, Liao Y, et al. Meningeal lymphatic vessels regulate brain tumor drainage and immunity. Cell Res. 2020;30:229-243 pubmed publisher
Engelbrecht E, Lévesque M, He L, Vanlandewijck M, Nitzsche A, Niazi H, et al. Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta. elife. 2020;9: pubmed publisher
Lioux G, Liu X, Temiño S, Oxendine M, Ayala E, Ortega S, et al. A Second Heart Field-Derived Vasculogenic Niche Contributes to Cardiac Lymphatics. Dev Cell. 2020;52:350-363.e6 pubmed publisher
Jafree D, Moulding D, Kolatsi Joannou M, Perretta Tejedor N, Price K, Milmoe N, et al. Spatiotemporal dynamics and heterogeneity of renal lymphatics in mammalian development and cystic kidney disease. elife. 2019;8: pubmed publisher
Rudzinska M, Mikula M, Arczewska K, Gajda E, Sabalińska S, Stepien T, et al. Transcription Factor Prospero Homeobox 1 (PROX1) as a Potential Angiogenic Regulator of Follicular Thyroid Cancer Dissemination. Int J Mol Sci. 2019;20: pubmed publisher
Gancz D, Raftrey B, Perlmoter G, Mar n Juez R, Semo J, Matsuoka R, et al. Distinct origins and molecular mechanisms contribute to lymphatic formation during cardiac growth and regeneration. elife. 2019;8: pubmed publisher
Carver C, Hastings S, Cook M, Shapiro M. Functional responses of the hippocampus to hyperexcitability depend on directed, neuron-specific KCNQ2 K+ channel plasticity. Hippocampus. 2019;: pubmed publisher
Thomson B, Carota I, Souma T, Soman S, Vestweber D, Quaggin S. Targeting the vascular-specific phosphatase PTPRB protects against retinal ganglion cell loss in a pre-clinical model of glaucoma. elife. 2019;8: pubmed publisher
Mahamud M, Geng X, Ho Y, Cha B, Kim Y, Ma J, et al. GATA2 controls lymphatic endothelial cell junctional integrity and lymphovenous valve morphogenesis through miR-126. Development. 2019;146: pubmed publisher
Kasurinen A, Gramolelli S, Hagstrom J, Laitinen A, Kokkola A, Miki Y, et al. High tissue MMP14 expression predicts worse survival in gastric cancer, particularly with a low PROX1. Cancer Med. 2019;8:6995-7005 pubmed publisher
Yoon S, Dieterich L, Karaman S, Proulx S, Bachmann S, Sciaroni C, et al. An important role of cutaneous lymphatic vessels in coordinating and promoting anagen hair follicle growth. PLoS ONE. 2019;14:e0220341 pubmed publisher
Denton A, Carr E, Magiera L, Watts A, Fearon D. Embryonic FAP+ lymphoid tissue organizer cells generate the reticular network of adult lymph nodes. J Exp Med. 2019;216:2242-2252 pubmed publisher
Ding X, Wang H, Qian X, Han X, Yang L, Cao Y, et al. Panicle-Shaped Sympathetic Architecture in the Spleen Parenchyma Modulates Antibacterial Innate Immunity. Cell Rep. 2019;27:3799-3807.e3 pubmed publisher
Sorrells S, Paredes M, Velmeshev D, Herranz Pérez V, Sandoval K, Mayer S, et al. Immature excitatory neurons develop during adolescence in the human amygdala. Nat Commun. 2019;10:2748 pubmed publisher
Norman T, Gower A, Chen F, Fine A. Transcriptional landscape of pulmonary lymphatic endothelial cells during fetal gestation. PLoS ONE. 2019;14:e0216795 pubmed publisher
Rudzinska M, Grzanka M, Stachurska A, Mikula M, Paczkowska K, Stepien T, et al. Molecular Signature of Prospero Homeobox 1 (PROX1) in Follicular Thyroid Carcinoma Cells. Int J Mol Sci. 2019;20: pubmed publisher
Genga R, Kernfeld E, Parsi K, Parsons T, Ziller M, Maehr R. Single-Cell RNA-Sequencing-Based CRISPRi Screening Resolves Molecular Drivers of Early Human Endoderm Development. Cell Rep. 2019;27:708-718.e10 pubmed publisher
Broggi M, Maillat L, Clement C, Bordry N, Corthesy P, Auger A, et al. Tumor-associated factors are enriched in lymphatic exudate compared to plasma in metastatic melanoma patients. J Exp Med. 2019;216:1091-1107 pubmed publisher
Pluvinage J, Haney M, Smith B, Sun J, Iram T, Bonanno L, et al. CD22 blockade restores homeostatic microglial phagocytosis in ageing brains. Nature. 2019;568:187-192 pubmed publisher
Carver C, Shapiro M. Gq-Coupled Muscarinic Receptor Enhancement of KCNQ2/3 Channels and Activation of TRPC Channels in Multimodal Control of Excitability in Dentate Gyrus Granule Cells. J Neurosci. 2019;39:1566-1587 pubmed publisher
Urner S, Planas Paz L, Hilger L, Henning C, Branopolski A, Kelly Goss M, et al. Identification of ILK as a critical regulator of VEGFR3 signalling and lymphatic vascular growth. EMBO J. 2019;38: pubmed publisher
Vuorio T, Ylä Herttuala E, Laakkonen J, Laidinen S, Liimatainen T, Yla Herttuala S. Downregulation of VEGFR3 signaling alters cardiac lymphatic vessel organization and leads to a higher mortality after acute myocardial infarction. Sci Rep. 2018;8:16709 pubmed publisher
Cha B, Geng X, Mahamud M, Zhang J, Chen L, Kim W, et al. Complementary Wnt Sources Regulate Lymphatic Vascular Development via PROX1-Dependent Wnt/β-Catenin Signaling. Cell Rep. 2018;25:571-584.e5 pubmed publisher
Högström J, Heino S, Kallio P, Lähde M, Leppänen V, Balboa D, et al. Transcription Factor PROX1 Suppresses Notch Pathway Activation via the Nucleosome Remodeling and Deacetylase Complex in Colorectal Cancer Stem-like Cells. Cancer Res. 2018;78:5820-5832 pubmed publisher
Goudarzi K, Espinoza J, Guo M, Bartek J, Nister M, Lindström M, et al. Reduced Expression of PROX1 Transitions Glioblastoma Cells into a Mesenchymal Gene Expression Subtype. Cancer Res. 2018;78:5901-5916 pubmed publisher
Gramolelli S, Cheng J, Martínez Corral I, Vaha Koskela M, Elbasani E, Kaivanto E, et al. PROX1 is a transcriptional regulator of MMP14. Sci Rep. 2018;8:9531 pubmed publisher
Frye M, Taddei A, Dierkes C, Martínez Corral I, Fielden M, Ortsäter H, et al. Matrix stiffness controls lymphatic vessel formation through regulation of a GATA2-dependent transcriptional program. Nat Commun. 2018;9:1511 pubmed publisher
Niquille M, Limoni G, Markopoulos F, Cadilhac C, Prados J, Holtmaat A, et al. Neurogliaform cortical interneurons derive from cells in the preoptic area. elife. 2018;7: pubmed publisher
Xu M, Han X, Liu R, Li Y, Qi C, Yang Z, et al. PDK1 Deficit Impairs the Development of the Dentate Gyrus in Mice. Cereb Cortex. 2019;29:1185-1198 pubmed publisher
Rudzinska M, Ledwon J, Gawel D, Sikorska J, Czarnocka B. The role of prospero homeobox 1 (PROX1) expression in follicular thyroid carcinoma cells. Oncotarget. 2017;8:114136-114155 pubmed publisher
Rhee S, Chung J, King D, D Amato G, Paik D, Duan A, et al. Endothelial deletion of Ino80 disrupts coronary angiogenesis and causes congenital heart disease. Nat Commun. 2018;9:368 pubmed publisher
Thomson B, Souma T, Tompson S, Onay T, Kizhatil K, Siggs O, et al. Angiopoietin-1 is required for Schlemm's canal development in mice and humans. J Clin Invest. 2017;127:4421-4436 pubmed publisher
Kim J, Park D, Bae H, Park D, Kim D, Lee C, et al. Impaired angiopoietin/Tie2 signaling compromises Schlemm's canal integrity and induces glaucoma. J Clin Invest. 2017;127:3877-3896 pubmed publisher
Lin Y, Ohbayashi N, Hongu T, Katagiri N, Funakoshi Y, Lee H, et al. Arf6 in lymphatic endothelial cells regulates lymphangiogenesis by controlling directional cell migration. Sci Rep. 2017;7:11431 pubmed publisher
Laitinen A, Böckelman C, Hagstrom J, Kokkola A, Kallio P, Haglund C. High PROX1 expression in gastric cancer predicts better survival. PLoS ONE. 2017;12:e0183868 pubmed publisher
Hägerling R, Drees D, Scherzinger A, Dierkes C, Martin Almedina S, Butz S, et al. VIPAR, a quantitative approach to 3D histopathology applied to lymphatic malformations. JCI Insight. 2017;2: pubmed publisher
Mimura Yamamoto Y, Shinohara H, Kashiwagi T, Sato T, Shioda S, Seki T. Dynamics and function of CXCR4 in formation of the granule cell layer during hippocampal development. Sci Rep. 2017;7:5647 pubmed publisher
Jung E, Gardner D, Choi D, Park E, Jin Seong Y, Yang S, et al. Development and Characterization of A Novel Prox1-EGFP Lymphatic and Schlemm's Canal Reporter Rat. Sci Rep. 2017;7:5577 pubmed publisher
Jha S, Rauniyar K, Karpanen T, Leppänen V, Brouillard P, Vikkula M, et al. Efficient activation of the lymphangiogenic growth factor VEGF-C requires the C-terminal domain of VEGF-C and the N-terminal domain of CCBE1. Sci Rep. 2017;7:4916 pubmed publisher
Yan K, Gevaert O, Zheng G, Anchang B, Probert C, Larkin K, et al. Intestinal Enteroendocrine Lineage Cells Possess Homeostatic and Injury-Inducible Stem Cell Activity. Cell Stem Cell. 2017;21:78-90.e6 pubmed publisher
Volk Draper L, Hall K, Wilber A, Ran S. Lymphatic endothelial progenitors originate from plastic myeloid cells activated by toll-like receptor-4. PLoS ONE. 2017;12:e0179257 pubmed publisher
Matsushita J, Inagaki S, Nishie T, Sakasai T, Tanaka J, Watanabe C, et al. Fluorescence and Bioluminescence Imaging of Angiogenesis in Flk1-Nano-lantern Transgenic Mice. Sci Rep. 2017;7:46597 pubmed publisher
Castellano J, Mosher K, Abbey R, McBride A, James M, Berdnik D, et al. Human umbilical cord plasma proteins revitalize hippocampal function in aged mice. Nature. 2017;544:488-492 pubmed publisher
Teoh J, Iwano T, Kunii M, Atik N, Avriyanti E, Yoshimura S, et al. BIG1 is required for the survival of deep layer neurons, neuronal polarity, and the formation of axonal tracts between the thalamus and neocortex in developing brain. PLoS ONE. 2017;12:e0175888 pubmed publisher
Frazer S, Prados J, Niquille M, Cadilhac C, Markopoulos F, Gomez L, et al. Transcriptomic and anatomic parcellation of 5-HT3AR expressing cortical interneuron subtypes revealed by single-cell RNA sequencing. Nat Commun. 2017;8:14219 pubmed publisher
Malinverno M, Corada M, Ferrarini L, Formicola L, Marazzi G, Sassoon D, et al. Peg3/PW1 Is a Marker of a Subset of Vessel Associated Endothelial Progenitors. Stem Cells. 2017;35:1328-1340 pubmed publisher
Iftakhar E Khuda I, Fair Mäkelä R, Kukkonen Macchi A, Elima K, Karikoski M, Rantakari P, et al. Gene-expression profiling of different arms of lymphatic vasculature identifies candidates for manipulation of cell traffic. Proc Natl Acad Sci U S A. 2016;113:10643-8 pubmed publisher
Lund A, Wagner M, Fankhauser M, Steinskog E, Broggi M, Spranger S, et al. Lymphatic vessels regulate immune microenvironments in human and murine melanoma. J Clin Invest. 2016;126:3389-402 pubmed publisher
Cha B, Geng X, Mahamud M, Fu J, Mukherjee A, Kim Y, et al. Mechanotransduction activates canonical Wnt/β-catenin signaling to promote lymphatic vascular patterning and the development of lymphatic and lymphovenous valves. Genes Dev. 2016;30:1454-69 pubmed publisher
Fatima A, Wang Y, Uchida Y, Norden P, Liu T, Culver A, et al. Foxc1 and Foxc2 deletion causes abnormal lymphangiogenesis and correlates with ERK hyperactivation. J Clin Invest. 2016;126:2437-51 pubmed publisher
Crosswhite P, Podsiadlowska J, Curtis C, Gao S, Xia L, Srinivasan R, et al. CHD4-regulated plasmin activation impacts lymphovenous hemostasis and hepatic vascular integrity. J Clin Invest. 2016;126:2254-66 pubmed publisher
Geng R, Noda T, Mulvaney J, Lin V, Edge A, Dabdoub A. Comprehensive Expression of Wnt Signaling Pathway Genes during Development and Maturation of the Mouse Cochlea. PLoS ONE. 2016;11:e0148339 pubmed publisher
Geng X, Cha B, Mahamud M, Lim K, Silasi Mansat R, Uddin M, et al. Multiple mouse models of primary lymphedema exhibit distinct defects in lymphovenous valve development. Dev Biol. 2016;409:218-233 pubmed publisher
product information
brand :
R&D Systems
master code :
AF2727
SKU :
AF2727
product name :
Human Prox1 Antibody
unit size :
100 ug (also 25 ug)
seo description :
The Human Prox1 Antibody from R&D Systems is a goat polyclonal antibody to Prox1. This antibody reacts with avian - chicken,human,mouse,porcine,rat,transgenic mouse,xenograft,fish - danio rerio (zebrafish). The Human Prox1 Antibody has been validated for the following applications: Immunohistochemistry,Western Blot,Immunocytochemistry,Flow Cytometry,Simple Western,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Chromatin Immunoprecipitation (ChIP),Immunocytochemistry/ Immunofluorescence.
target :
Prox1
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Polyclonal
concentration :
LYOPH
conjugate :
Unconjugated
dilution :
Western Blot 1 ug/mL, Simple Western 10 ug/mL, Immunocytochemistry 5-15 ug/mL
host :
Goat
immunogen :
E. coli -derived recombinant human Prox1, Pro2-Gln259, Accession # Q92786
isotype :
IgG
purity :
Antigen Affinity-purified
species :
Avian - Chicken,Human,Mouse,Porcine,Rat,Transgenic Mouse,Xenograft,Fish - Danio rerio (Zebrafish)
specificity :
Detects human Prox1 in direct ELISAs and Western blots.
gene symbol :
PROX1
top caption :
Detection of Human Prox1 antibody by Western Blot.
accessionNumbers :
Q92786
applications :
Flow Cytometry,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Simple Western,Chromatin Immunoprecipitation (ChIP),Immunocytochemistry,Immunocytochemistry/ Immunofluorescence
USD :
509 USD
alt names :
Homeobox prospero-like protein PROX1, prospero homeobox 1, prospero homeobox protein 1, prospero-related homeobox 1, PROX-1
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.