Human Nectin-4 Antibody | R&D Systems AF2659 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human Nectin-4 Antibody

catalog :

AF2659

quantity :

100 ug (also 25 ug)

price :

489 USD

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

human, mouse, dogs

application :

western blot, immunohistochemistry, immunocytochemistry, neutralization, flow cytometry, immunohistochemistry - paraffin section

more info or order :

R&D Systems product webpage

citations: 10

Reference
Tamura K, Fujiyuki T, Moritoh K, Akimoto H, Iizuka K, Sato H, et al. Anti-tumor activity of a recombinant measles virus against canine lung cancer cells. Sci Rep. 2023;13:18168 pubmed publisher
Moritoh K, Shoji K, Amagai Y, Fujiyuki T, Sato H, Yoneda M, et al. Immune response elicited in the tumor microenvironment upon rMV-SLAMblind cancer virotherapy. Cancer Sci. 2023;114:2158-2168 pubmed publisher
Gradauskaite V, Inglebert M, Doench J, Scherer M, Dettwiler M, Wyss M, et al. LRP6 Is a Functional Receptor for Attenuated Canine Distemper Virus. MBio. 2023;14:e0311422 pubmed publisher
Li F, Zhao S, Wei C, Hu Y, Xu T, Xin X, et al. Development of Nectin4/FAP-targeted CAR-T cells secreting IL-7, CCL19, and IL-12 for malignant solid tumors. Front Immunol. 2022;13:958082 pubmed publisher
Upadhyaya P, Lahdenranta J, Hurov K, Battula S, Dods R, Haines E, et al. Anticancer immunity induced by a synthetic tumor-targeted CD137 agonist. J Immunother Cancer. 2021;9: pubmed publisher
Iizuka K, Shoji K, Fujiyuki T, Moritoh K, Tamura K, Yoshida A, et al. Antitumor activity of an oncolytic measles virus against canine urinary bladder transitional cell carcinoma cells. Res Vet Sci. 2020;133:313-317 pubmed publisher
Deng H, Shi H, Chen L, Zhou Y, Jiang J. Over-expression of Nectin-4 promotes progression of esophageal cancer and correlates with poor prognosis of the patients. Cancer Cell Int. 2019;19:106 pubmed publisher
della Salda L, Massimini M, Romanucci M, Palmieri C, Perillo A, Grieco V, et al. Nectin-4 and p63 immunohistochemical expression in canine prostate tumourigenesis. Vet Comp Oncol. 2019;17:298-307 pubmed publisher
Pratakpiriya W, Ping Teh A, Radtanakatikanon A, Pirarat N, Thi Lan N, Takeda M, et al. Expression of canine distemper virus receptor nectin-4 in the central nervous system of dogs. Sci Rep. 2017;7:349 pubmed publisher
Kitayama M, Mizutani K, Maruoka M, Mandai K, Sakakibara S, Ueda Y, et al. A Novel Nectin-mediated Cell Adhesion Apparatus That Is Implicated in Prolactin Receptor Signaling for Mammary Gland Development. J Biol Chem. 2016;291:5817-31 pubmed publisher

product information

master code :

AF2659

SKU :

AF2659

product name :

Human Nectin-4 Antibody

unit size :

100 ug (also 25 ug)

description :

The Human Nectin-4 Antibody from R&D Systems is a goat polyclonal antibody to Nectin-4/PVRL4. This antibody reacts with canine,hamster,human,mouse,porcine,primate - chlorocebus aethiops (african green monkey),primate - macaca fascicularis (crab-eating monkey or cynomolgus macaque),xenograft. The Human Nectin-4 Antibody has been validated for the following applications: Western Blot,Neutralization,Immunohistochemistry,Westen Blot,Flow Cytometry,Functional Assay,Immunohistochemistry-Paraffin,Immunocytochemistry,CyTOF-ready.

target :

Nectin-4

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Polyclonal

concentration :

LYOPH

conjugate :

Unconjugated

host :

Goat

immunogen :

Mouse myeloma cell line NS0-derived recombinant human Nectin-4, Gly27-Val351, Accession # Q96NY8

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Canine,Hamster,Human,Mouse,Porcine,Primate - Chlorocebus aethiops (African Green Monkey),Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque),Xenograft

specificity :

Detects human Nectin-4 in direct ELISAs and Western blots. In direct ELISAs, approximately 75% cross-reactivity with recombinant mouse Nectin-4 is observed.

gene symbol :

PVRL4

Antibody validation :

Knockout/Knockdown

top caption :

Nectin-4 antibody in Human Placenta by Immunohistochemistry (IHC-P).

accessionNumbers :

Q96NY8

applications :

Neutralization,Immunohistochemistry,Western Blot,Westen Blot,Flow Cytometry,Functional Assay,Immunohistochemistry-Paraffin,Immunocytochemistry,CyTOF-ready

USD :

489 USD

alt names :

EDSS1, Ig superfamily receptor LNIR, LNIR, LNIRnectin 4, nectin-4, Nectin4, poliovirus receptor-related 4, poliovirus receptor-related protein 4, PRR4, PRR4DKFZp686K05193, PVRL4

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage