product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human Amphiregulin Antibody
catalog :
AF262
quantity :
100 ug (also 25 ug)
price :
499 USD
clonality :
polyclonal
host :
domestic goat
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, neutralization, immunohistochemistry - paraffin section
more info or order :
R&D Systems product webpage
citations: 16
Reference
Dahlgren M, Lettiero B, Dalal H, M xe5 rtensson K, Gaber A, Nodin B, et al. CITED1 as a marker of favourable outcome in anti-endocrine treated, estrogen-receptor positive, lymph-node negative breast cancer. BMC Res Notes. 2023;16:105 pubmed publisher
Marie P, Fan S, Mason J, Wells A, Mendes C, Wainwright S, et al. Accessory ESCRT-III proteins are conserved and selective regulators of Rab11a-exosome formation. J Extracell Vesicles. 2023;12:e12311 pubmed publisher
Liu Y, Zhong Y, Shen X, Guo X, Wu R, Yang T, et al. Luteinizing hormone stimulates the expression of amphiregulin in human theca cells. J Ovarian Res. 2022;15:129 pubmed publisher
Lofgren K, Reker N, Sreekumar S, Kenny P. Pan-cancer distribution of cleaved cell-surface amphiregulin, the target of the GMF-1A3 antibody drug conjugate. Antib Ther. 2022;5:226-231 pubmed publisher
Hino Y, Nagaoka K, Oki S, Etoh K, Hino S, Nakao M. Mitochondrial stress induces AREG expression and epigenomic remodeling through c-JUN and YAP-mediated enhancer activation. Nucleic Acids Res. 2022;50:9765-9779 pubmed publisher
Agaronyan K, Sharma L, Vaidyanathan B, Glenn K, Yu S, Annicelli C, et al. Tissue remodeling by an opportunistic pathogen triggers allergic inflammation. Immunity. 2022;55:895-911.e10 pubmed publisher
Lofgren K, Sreekumar S, Jenkins E, Ernzen K, Kenny P. Anti-tumor efficacy of an MMAE-conjugated antibody targeting cell surface TACE/ADAM17-cleaved Amphiregulin in breast cancer. Antib Ther. 2021;4:252-261 pubmed publisher
Xiao Z, Hammes S. AXL cooperates with EGFR to mediate neutrophil elastase-induced migration of prostate cancer cells. iScience. 2021;24:103270 pubmed publisher
Fan S, Kroeger B, Marie P, Bridges E, Mason J, McCormick K, et al. Glutamine deprivation alters the origin and function of cancer cell exosomes. EMBO J. 2020;39:e103009 pubmed publisher
Kefaloyianni E, Keerthi Raja M, Schumacher J, Muthu M, Krishnadoss V, Waikar S, et al. Proximal Tubule-Derived Amphiregulin Amplifies and Integrates Profibrotic EGF Receptor Signals in Kidney Fibrosis. J Am Soc Nephrol. 2019;30:2370-2383 pubmed publisher
Canto L, Cury S, Barros Filho M, Kupper B, Begnami M, Scapulatempo Neto C, et al. Locally advanced rectal cancer transcriptomic-based secretome analysis reveals novel biomarkers useful to identify patients according to neoadjuvant chemoradiotherapy response. Sci Rep. 2019;9:8702 pubmed publisher
Mikuličić S, Finke J, Boukhallouk F, Wüstenhagen E, Sons D, Homsi Y, et al. ADAM17-dependent signaling is required for oncogenic human papillomavirus entry platform assembly. elife. 2019;8: pubmed publisher
Platen C, Dreschers S, Reiss L, Wappler J, Orlikowsky T. Amphiregulin Regulates Phagocytosis-Induced Cell Death in Monocytes via EGFR and Matrix Metalloproteinases. Mediators Inflamm. 2018;2018:4310419 pubmed publisher
Jia J, Li C, Yang J, Wang X, Li R, Luo S, et al. Yes-associated protein promotes the abnormal proliferation of psoriatic keratinocytes via an amphiregulin dependent pathway. Sci Rep. 2018;8:14513 pubmed publisher
Dong W, Liu L, Dou Y, Xu M, Liu T, Wang S, et al. Deoxycholic acid activates epidermal growth factor receptor and promotes intestinal carcinogenesis by ADAM17-dependent ligand release. J Cell Mol Med. 2018;22:4263-4273 pubmed publisher
Mésange P, Bouygues A, Ferrand N, Sabbah M, Escargueil A, Savina A, et al. Combinations of Bevacizumab and Erlotinib Show Activity in Colorectal Cancer Independent of RAS Status. Clin Cancer Res. 2018;24:2548-2558 pubmed publisher
product information
brand :
R&D Systems
master code :
AF262
SKU :
AF262
product name :
Human Amphiregulin Antibody
unit size :
100 ug (also 25 ug)
seo description :
The Human Amphiregulin Antibody from R&D Systems is a goat polyclonal antibody to Amphiregulin. This antibody reacts with human,mouse. The Human Amphiregulin Antibody has been validated for the following applications: Western Blot,Neutralization,Functional Assay,ELISA Capture,Immunohistochemistry,Immunohistochemistry-Paraffin,Immunocytochemistry.
target :
Amphiregulin
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Polyclonal
concentration :
LYOPH
conjugate :
Unconjugated
dilution :
Western Blot 1 ug/mL, Immunohistochemistry 5-15 ug/mL, Neutralization 0.3-1 ug/mL, Immunocytochemistry 5-15 ug/mL
host :
Goat
immunogen :
E. coli -derived recombinant human Amphiregulin, Val107-Lys184, Accession # P15514
isotype :
IgG
purity :
Antigen Affinity-purified
species :
Human,Mouse
specificity :
Detects human Amphiregulin in direct ELISAs and Western blots. In direct ELISAs, less than 5% cross-reactivity with recombinant mouse (rm) Amphiregulin, rmEpiregulin, recombinant human (rh) HB-EGF, and rhTGF-alpha is observed.
gene symbol :
AREG
endotoxin note :
<0.10 EU per 1 ╡g of the antibody by the LAL method.
top caption :
Detection of Human Amphiregulin antibody by Western Blot.
accessionNumbers :
P15514
applications :
Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Neutralization,Immunocytochemistry,Functional Assay,ELISA Capture
USD :
499 USD
alt names :
amphiregulin, AR, AREG, AREGB, Colorectum cell-derived growth factor, CRDGF, MGC13647, schwannoma-derived growth factor, SDGF
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.